Type IV collagenases in tumor invasion and metastasis

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Zinc coordination, function, and structure of zinc enzymes and other proteins

1990 • 1,731 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

Cancer statistics, 1990

1990 • 818 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

1985 • 702 citations

The basement membrane in pathology.

1983 • 660 citations

Antibodies to plasminogen activator inhibit human tumor metastasis

1983 • 651 citations

Independent Regulation of Collagenase, 72-kDa Progelatinase, and Metalloendoproteinase Inhibitor Expression in Human Fibroblasts by Transforming Growth Factor-β

1989 • 649 citations

Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.

1985 • 625 citations

Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

1989 • 594 citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

1989 • 579 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1986 • 531 citations

Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.

1987 • 508 citations

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

1985 • 506 citations

Identification of an Inhibitor of Neovascularization from Cartilage

1990 • 481 citations

Adhesive and degradative properties of human placental cytotrophoblast cells in vitro.

1989 • 477 citations

The Approaching Era of the Tumor Suppressor Genes

1987 • 468 citations

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1989 • 462 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.

1979 • 452 citations

Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

1990 • 428 citations

Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.

1990 • 406 citations

Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines.

1990 • 379 citations

The collagenase gene family in humans consists of at least four members

1988 • 364 citations

Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells

1988 • 352 citations

The Activation of Human Type IV Collagenase Proenzyme

1989 • 347 citations

Basement Membrane Collagen: Degradation by Migrating Endothelial Cells

1983 • 345 citations

Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells.

1987 • 323 citations

Immunohistochemical distribution of type IV collagenase in normal, benign, and malignant breast tissue.

1990 • 323 citations

Tumor invasion and metastases: role of the basement membrane. Warner-Lambert Parke-Davis Award lecture.

1984 • 321 citations

Degradation of basement membrane type IV collagen and lung subendothelial matrix by rat mammary adenocarcinoma cell clones of differing metastatic potentials.

1987 • 315 citations

Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.

1988 • 312 citations

Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells.

1981 • 304 citations

Molecular characterization and expression of the gene encoding human erythroid-potentiating activity

1985 • 279 citations

Primary structure and cDNA cloning of human fibroblast collagenase inhibitor.

1986 • 274 citations

Tumor heterogeneity.

1984 • 264 citations

Characterization of the Cellular Binding Site for the Urokinase-type Plasminogen Activator

1989 • 248 citations

Inhibition of Collagenolytic Activity and Metastasis of Tumor Cells by a Recombinant Human Tissue Inhibitor of Metalloproteinases

1990 • 233 citations

Human skin fibroblast collagenase inhibitor. Comparative studies in human connective tissues, serum, and amniotic fluid.

1983 • 231 citations

Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.

1987 • 226 citations

Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture. Stimulation by 12-O-tetradecanoylphorbol 13-acetate and interleukin 1 in parallel with collagenase.

1985 • 220 citations

Ras oncogene mediated induction of a 92kDa metalloproteinase; strong correlation with the malignant phenotype

1988 • 209 citations

Partial purification of collagenase and gelatinase from human polymorphonuclear leucocytes. Analysis of their actions on soluble and insoluble collagens

1982 • 203 citations

Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells.

1990 • 202 citations

cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.

1990 • 202 citations

Human alveolar macrophages produce a fibroblast-like collagenase and collagenase inhibitor.

1985 • 199 citations

Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells

1989 • 193 citations

Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells.

1990 • 180 citations

Characterization of the procollagen IV cleavage products produced by a specific tumor collagenase.

1984 • 178 citations

Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell.

1985 • 175 citations

Conditioned tumorigenicity of activated oncogenes.

1986 • 173 citations

An inhibitor of collagenase from human amniotic fluid. Purification, characterization and action on metalloproteinases

1981 • 171 citations

Structure-function relationships in the collagenase family member transin.

1988 • 169 citations

Human Skin Fibroblast Collagenase: Interaction with Substrate and Inhibitor

1985 • 167 citations

Expression of type IV collagenase and procollagen genes and its correlation with the tumorigenic, invasive, and metastatic abilities of oncogene-transformed human bronchial epithelial cells.

1989 • 163 citations

Inhibition by retinoic acid of type IV collagenolysis and invasion through reconstituted basement membrane by metastatic rat mammary adenocarcinoma cells.

1989 • 151 citations

Expression of Collagenase IV (Basement Membrane Collagenase) Activity in Murine Tumor Cell Hybrids That Differ in Metastatic Potential<xref ref-type="fn" rid="FN2">2</xref>

1985 • 145 citations

Effect of Natural Protease Inhibitors and a Chemoattractant on Tumor Cell Invasion In Vitro

1982 • 141 citations

Retinoic acid inhibition of human melanoma cell invasion through a reconstituted basement membrane and its relation to decreases in the expression of proteolytic enzymes and motility factor receptor.

1990 • 126 citations

Expression of Human Recombinant Plasminogen Activators Enhances Invasion and Experimental Metastasis of H-ras-Transformed NIH 3T3 Cells

1989 • 120 citations

Evidence that human rheumatoid synovial matrix metalloproteinase 3 is an endogenous activator of procollagenase

1988 • 120 citations

Gelatinases of metastatic cell lines of murine colonic carcinoma as detected by substrate-gel electrophoresis

1988 • 117 citations

Tumor suppressors: Recessive mutations that lead to cancer

1988 • 115 citations

Clonal dominance of primary tumours by metastatic cells: genetic analysis and biological implications.

1988 • 105 citations

Invasive and Metastatic Potential of a v-Ha-ras-Transformed Human Bronchial Epithelial Cell Line

1989 • 103 citations

K562 cells produce and respond to human erythroid-potentiating activity

1988 • 99 citations

Purification of a Type V Collagen Degrading Metalloproteinase from Rabbit Alveolar Macrophages

1984 • 98 citations

Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells.

1989 • 95 citations

Tumour basement membrane laminin in adenocarcinoma of rectum: An immunohistochemical study of biological and clinical significance

1986 • 93 citations

Tissue-type plasminogen activator, a new prognostic marker in breast cancer.

1988 • 88 citations

Gelatinase (type iv collagenase) immunolocalization in cells and tissues: Use of an antiserum to rabbit bone gelatinase that identifies high and low M r forms

1989 • 87 citations

Random and nonrandom processes in metastasis, and metastatic inefficiency.

1983 • 84 citations

Metastasis Suppressor Genes

1990 • 75 citations

Surgical Treatment of Metastatic Cancer

1988 • 68 citations

Multilocus molecular mapping of the mouse X chromosome

1988 • 62 citations

A primary genetic map of the pericentromeric region of the human X chromosome

1988 • 59 citations

A latent Mr 94,000 gelatin-degrading metalloprotease induced during differentiation of HL-60 promyelocytic leukemia cells: a member of the collagenase family of enzymes.

1990 • 56 citations

Human Alveolar Macrophages Produce a Fibroblast-like Collagenase and Collagenase Inhibitor

1986 • 54 citations

Blocking of collagenase secretion by estramustine during in vitro tumor cell invasion.

1988 • 47 citations

Role of oncogenes in metastases

1988 • 43 citations

Surgical treatment of metastatic cancer

1987 • 42 citations

K562 cells produce and respond to human erythroid-potentiating activity

1988 • 35 citations

Differential effects of phorbol ester on the in vitro invasiveness of malignant and non‐malignant human fibroblast cells

1990 • 33 citations

Analysis of the near-ultraviolet absorption and circular dichroic spectra of parsley plastocyanin for the effects of pH and copper center conformation changes

1988 • 11 citations