Therapeutic Regulation of the Complement System in Acute Injury States

Complement Activation during Cardiopulmonary Bypass

1981 • 1,163 citations

Complement and Leukocyte-Mediated Pulmonary Dysfunction in Hemodialysis

1977 • 1,014 citations

Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes.

1977 • 1,004 citations

Soluble Human Complement Receptor Type 1: In Vivo Inhibitor of Complement Suppressing Post-Ischemic Myocardial Inflammation and Necrosis

1990 • 989 citations

Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation

1991 • 796 citations

Complement (C5-a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostasis and leukopenia.

1977 • 696 citations

The chemotactic receptor for human C5a anaphylatoxin

1991 • 660 citations

Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte

1980 • 645 citations

Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system.

1982 • 603 citations

Membrane Cofactor Protein (MCP or CD46): Newest Member of the Regulators of Complement Activation Gene Cluster

1991 • 582 citations

Inhibition of complement activation on the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes.

1984 • 571 citations

ASSOCIATION OF COMPLEMENT ACTIVATION AND ELEVATED PLASMA-C5a WITH ADULT RESPIRATORY DISTRESS SYNDROME

1980 • 561 citations

Intravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites.

1982 • 554 citations

Medical Treatment of Osteoarthritis

1965 • 554 citations

Transplantation of discordant xenografts: a review of progress

1990 • 538 citations

The role of membrane receptors for C3b and C3d in phagocytosis.

1977 • 536 citations

Complement-Induced Granulocyte Aggregation

1980 • 520 citations

Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification procedures.

1983 • 474 citations

Tumor-promoting phorbol esters stimulate C3b and C3b' receptor-mediated phagocytosis in cultured human monocytes.

1982 • 444 citations

Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane

1979 • 444 citations

Regulation by membrane sialic acid of β1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway

1978 • 415 citations

XENOGENEIC TRANSPLANTATION

1988 • 400 citations

Human neutrophils increase expression of C3bi as well as C3b receptors upon activation.

1984 • 391 citations

A novel divalent cation-binding site in the a domain of the ?2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1993 • 383 citations

Release of decay-accelerating factor (DAF) from the cell membrane by phosphatidylinositol-specific phospholipase C (PIPLC). Selective modification of a complement regulatory protein.

1986 • 358 citations

Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex.

1990 • 342 citations

Human alternative complement pathway: membrane-associated sialic acid regulates the competition between B and beta1 H for cell-bound C3b.

1979 • 339 citations

Mode of Inheritance of Decreased C3b Receptors on Erythrocytes of Patients with Systemic Lupus Erythematosus

1982 • 334 citations

PROLONGATION OF CARDIAC XENOGRAFT SURVIVAL BY DEPLETION OF COMPLEMENT

1993 • 320 citations

Increased Susceptibility to Infection Associated with Abnormalities of Complement-Mediated Functions and of the Third Component of Complement (C3)

1970 • 316 citations

Leukocyte Adhesion Molecules Deficiency: Its Structural Basis, Pathophysiology and Implications for Modulating the Inflammatory Response

1990 • 307 citations

Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates.

1986 • 267 citations

Increased Expression of an Adhesion-Promoting Surface Glycoprotein in the Granulocytopenia of Hemodialysis

1985 • 265 citations

Reduction by Cobra Venom Factor of Myocardial Necrosis after Coronary Artery Occlusion

1978 • 264 citations

Human Alternative Complement Pathway: Membrane-Associated Sialic Acid Regulates the Competition between B and β1H for Cell-Bound C3b

1979 • 257 citations

Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes.

1984 • 257 citations

Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients.

1992 • 249 citations

Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli.

1991 • 248 citations

Soluble complement receptor type 1 ameliorates the local and remote organ injury after intestinal ischemia-reperfusion in the rat.

1992 • 247 citations

THE MECHANISM OF DISCORDANT XENOGRAFT REJECTION

1988 • 245 citations

Suppression of the Immune Response by a Soluble Complement Receptor of B Lymphocytes

1991 • 242 citations

Isolation of a human erythrocyte membrane protein capable of inhibiting expression of homologous complement transmembrane channels.

1986 • 240 citations

Deposition of the terminal C5b-9 complement complex in infarcted areas of human myocardium.

1986 • 240 citations

Activation of the Properdin Pathway of Complement in Patients with Gram-Negative Bacteremia

1975 • 235 citations

Roles of histamine, complement and xanthine oxidase in thermal injury of skin.

1989 • 233 citations

Heparin and modified heparin inhibit complement activation in vivo.

1992 • 223 citations

Leukocyte depletion attenuates vascular injury in postischemic skeletal muscle

1988 • 221 citations

Neutrophil Receptors for IgG and Complement: Their Roles in the Attachment and Ingestion Phases of Phagocytosis

1976 • 210 citations

Hypocomplementaemia due to a genetic deficiency of beta 1H globulin.

1981 • 207 citations

In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromes.

1993 • 199 citations

Recycling and target binding capacity of human natural killer cells.

1981 • 196 citations

Distribution of protectin (CD59), a complement membrane attack inhibitor, in normal human tissues.

1991 • 195 citations

Autoantibody-Mediated Acquired Deficiency of C1 Inhibitor

1987 • 195 citations

Endotoxin-induced shock in the rat. A role for C5a.

1989 • 182 citations

Deficiency of a Granulocyte-Membrane Glycoprotein (gp150) in a Boy with Recurrent Bacterial Infections

1982 • 180 citations

The Effects of Complement Activation During Cardiopulmonary Bypass

1988 • 179 citations

Prevalence of Congenital or Acquired Complement Deficiency in Patients with Sporadic Meningococcal Disease

1983 • 173 citations

Signaling properties of CR3 (CD11b/CD18) and CR1 (CD35) in relation to phagocytosis of complement-opsonized particles.

1993 • 166 citations

Modulation of the formation of the amplification convertase of complement, C3b, Bb, by native and commercial heparin.

1978 • 165 citations

Protective effects of soluble CR1 in complement- and neutrophil-mediated tissue injury.

1992 • 165 citations

Structural Determinants of the Capacity of Heparin to Inhibit the Formation of the Human Amplification C3 Convertase

1981 • 156 citations

Deposition of Terminal C5b–9 Complement Complexes on Erythrocytes and Leukocytes during Cardiopulmonary Bypass

1988 • 155 citations

THE EFFECT OF SOLUBLE COMPLEMENT RECEPTOR TYPE 1 ON HYPERACUTE XENOGRAFT REJECTION

1991 • 154 citations

Neutrophil Activation in Thermal Injury as Assessed by Increased Expression of Complement Receptors

1986 • 151 citations

Rapid induction of neutrophil–endothelial adhesion by endothelial complement fixation

1989 • 150 citations

Role of beta 1, beta 2 integrins and ICAM-1 in lung injury after deposition of IgG and IgA immune complexes.

1993 • 149 citations

Receptor class desensitization of leukocyte chemoattractant receptors.

1991 • 146 citations

Distinct receptor and regulatory properties of recombinant mouse complement receptor 1 (CR1) and Crry, the two genetic homologues of human CR1.

1992 • 140 citations

Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation.

1981 • 129 citations

Characterization of a soluble form of the C3b/C4b receptor (CR1) in human plasma.

1985 • 127 citations

Membrane cofactor protein of complement is present on human fibroblast, epithelial, and endothelial cells.

1989 • 126 citations

Microvascular effects of complement blockade with soluble recombinant CR1 on ischemia/reperfusion injury of skeletal muscle.

1993 • 124 citations

Tumor necrosis factor is the major monocyte product that increases complement receptor expression on mature human neutrophils

1988 • 123 citations

Blockade of Complement Activation Prevents Local and Pulmonary Albumin Leak After Lower Torso Ischemia—Reperfusion

1992 • 120 citations

Immune Response of a Patient with Deficiency of the Fourth Component of Complement and Systemic Lupus Erythematosus

1979 • 119 citations

Production of acute pulmonary injury by leukocytes and activated complement.

1980 • 118 citations

Anaphylatoxin Generation in Multisystem Organ Failure

1984 • 115 citations

Tissue-specific phosphorylation of complement receptors CR1 and CR2.

1986 • 115 citations

Role of leukocyte adhesion molecules in complement-induced lung injury.

1993 • 115 citations

Membrane distribution and adsorptive endocytosis by C3b receptors on human polymorphonuclear leukocytes.

1981 • 112 citations

Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele.

1989 • 111 citations

Characterization of the human complement (c3b) receptor with a fluid phase C3b dimer.

1981 • 104 citations

Membrane cofactor protein (CD46) protects cells predominantly from alternative complement pathway-mediated C3-fragment deposition and cytolysis.

1993 • 101 citations

Deactivation of human neutrophil chemotaxis by chemoattractants: effect on receptors for the chemotactic factor f-Met-Leu-Phe.

1981 • 97 citations

Recombinant soluble human complement receptor type 1 inhibits inflammation in the reversed passive arthus reaction in rats.

1991 • 95 citations

Lung injury after deposition of IgA immune complexes. Requirements for CD18 and L-arginine.

1992 • 94 citations

Complement: Clinical Aspects and Relevance to Disease

1991 • 93 citations

Loss of expression of protectin (CD59) is associated with complement membrane attack complex deposition in myocardial infarction.

1992 • 90 citations

Complement activation and clearance in acute illness and injury: evidence for C5a as a cell-directed mediator of the adult respiratory distress syndrome in man.

1985 • 86 citations

A second case of human C3b inhibitor (KAF) deficiency.

1977 • 85 citations

Mapping of the C3b-binding site of CR1 and construction of a (CR1)2-F(ab')2 chimeric complement inhibitor.

1991 • 85 citations

Formation of C5a during cardiopulmonary bypass: Inhibition by precoating with heparin

1991 • 84 citations

Anaphylatoxin Formation in Sepsis

1988 • 84 citations

Interaction of prostaglandins, activated complement, and granulocytes in clinical sepsis and hypotension

1986 • 81 citations

Dysfunctional Properdin in a Dutch Family with Meningococcal Disease

1988 • 81 citations

Activation of complement by hydroxyl radical in thermal injury.

1988 • 79 citations

A postulated mechanism for heparin's potentiation of C1 inhibitor function

1982 • 79 citations

Consumptive Opsoninopathy

1976 • 79 citations

A Complement Inhibitor Produced by Stachybotrys complementi, nov. sp. K‐76, a New Species of Fungi Imperfecti

1980 • 78 citations

Complement: Clinical aspects and relevance to disease

1991 • 78 citations

Heparin‐Coated Equipment Reduces Complement Activation during Cardiopulmonary Bypass in the Pig

1990 • 77 citations

The binding properties of human complement component C1q. Interaction with mucopolysaccharides.

1983 • 75 citations

Role of complement in endotoxin/platelet-activating factor-induced lung injury.

1992 • 73 citations

Pulmonary Hypertension and Leukosequestration after Lower Torso Ischemia

1987 • 73 citations

Relative roles of decay‐accelerating factor, membrane cofactor protein, and CD59 in the protection of human endothelial cells against complement‐mediated lysis

1992 • 72 citations

Complement activation and white cell sequestration in postischemic skeletal muscle

1990 • 72 citations

Regulatory control of the terminal complement proteins at the surface of human endothelial cells: neutralization of a C5b-9 inhibitor by antibody to CD59

1990 • 72 citations

PROLONGING DISCORDANT XENOGRAFT SURVIVAL WITH ANTICOMPLEMENT REAGENTS K76COOH AND FUT175

1993 • 72 citations

New synthetic inhibitor to the alternative complement pathway.

1983 • 71 citations

Preferential Activation and Depletion of the Alternative Complement Pathway by Burn Injury

1983 • 70 citations

Inhibition of the alternative pathway of human complement in vitro by a natural microbial product, complestatin.

1980 • 65 citations

Alternative complement pathway activation increases mortality in a model of burn injury in mice.

1982 • 64 citations

The effect of soluble complement receptor type 1 on hyperacute allograft rejection

1991 • 64 citations

Amplified gene expression in CD59-transfected Chinese hamster ovary cells confers protection against the membrane attack complex of human complement

1991 • 63 citations

Granulocyte-macrophage colony-stimulating factor increases synthesis and expression of CR1 and CR3 by human peripheral blood neutrophils.

1990 • 63 citations

SERUM PROTEIN PROFILES IN THERMAL BURNS II. Protease Inhibitors, Complement Factors, and C-Reactive Protein

1974 • 59 citations

Initiation of C3 cleavage in the alternative complement pathway.

1975 • 58 citations

Increased expression of the C3b receptor by neutrophils and complement activation during haemodialysis.

1984 • 58 citations

Heparin prevents formation of the human C3 amplification convertase by inhibiting the binding site for B on C3b

1983 • 57 citations

Leukocyte CD11b/18 Antigen-directed Monoclonal Antibody Improves Early Survival and Decreases Hypoxemia in Dogs Challenged with Tumor Necrosis Factor

1992 • 57 citations

Potentiation of factor H by heparin: A rate-limiting mechanism for inhibition of the alternative complement pathway

1983 • 54 citations

Soluble complement receptor type 1 prevents human complement-mediated damage of the rabbit isolated heart.

1993 • 53 citations

A single dose of endotoxin activates neutrophils without activating complement.

1987 • 51 citations

Regulation of Neutrophil Migratory Function in Burn Injury by Complement Activation Products

1984 • 50 citations

Induction of zymosan‐air‐pouch inflammation in rats and its characterization with reference to the effects of anticomplementary and anti‐inflammatory agents

1983 • 50 citations

Initiation of C3 Cleavage in the Alternative Complement Pathway

1975 • 49 citations

Role of neutrophil adherence receptors (CD 18) in lung permeability following lower torso ischemia.

1992 • 48 citations

CHANGES IN THE HUMAN COMPLEMENT SYSTEM FOLLOWING BURN TRAUMA

1963 • 48 citations

IgG on mouse erythrocytes augments activation of the human alternative complement pathway by enhancing deposition of C3b.

1981 • 48 citations

Inhibition of Various Immunological Reactions in vivo by a New Synthetic Complement Inhibitor

1982 • 47 citations

The effect of FUT-175 (nafamstat mesilate) on C3a, C4a and C5a generation in vitro and inflammatory reactions in vivo

1990 • 44 citations

DETECTION OF RENAL ALLOGRAFT REJECTION IN MAN BY DEMONSTRATION OF A REDUCTION IN THE SERUM CONCENTRATION OF THE SECOND COMPONENT OF COMPLEMENT*

1966 • 41 citations

The Effect of Thermal Injury on Hemodynamic, Respiratory, and Hematologic Variables in Relation to Complement Activation

1979 • 41 citations

The anti mac-1 monoclonal antibody inhibits neutrophil sequestration in lung and liver in a septic murine model

1991 • 41 citations

Effects of cyclosporine, aspirin, and cobra venom factor on discordant cardiac xenograft survival in rats.

1987 • 40 citations

REACTION OF COMPLEMENT WITH ENDOTHEUAL CELLS IN A MODEL OF XEN0TRANSPLANTATION

1991 • 39 citations

Complement-induced expression of cryptic receptors on the neutrophil surface: a mechanism for regulation of acute inflammation in trauma.

1984 • 37 citations

Dominant role of complement in the hyperacute xenograft rejection reaction.

1976 • 36 citations

Selective up-regulation of human granulocyte integrins and complement receptor 1 by cytokines.

1991 • 35 citations

Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins.

1988 • 33 citations

Inhibition of the enzymatic activity of the first component of complement (C1) by heparin

1976 • 30 citations

C1 esterase inhibitor gene expression in rat Kupffer cells, peritoneal macrophages and blood monocytes: modulation by interferon gamma.

1993 • 30 citations

Recurrent Bacterial Infections Associated with C3 Nephritic Factor and Hypocomplementemia

1983 • 27 citations

Frequency of Complement Deficiencies in Man, Disease Associations and Chromosome Assignment of Complement Genes and Linkage Groups

1989 • 25 citations

Reduction in Alternative Complement Pathway Mediated C3 Conversion following Burn Injury

1981 • 24 citations

Prolongation of guinea pig cardiac xenograft survival in rats by soluble human complement receptor type 1.

1992 • 23 citations

Immunobiology of the complement system : an introduction for research and clinical medicine

1986 • 21 citations

Inhibition of human and guinea pig complement by heparin fractions differing in affinity for antithrombin III or in average molecular weight

1985 • 19 citations

Effect of the anticomplementary agent, K-76 monocarboxylic acid, on experimental immune complex glomerulonephritis in rats.

1987 • 16 citations

Recombinant Human Tumor Necrosis Factor Increases Granulocyte Cell-Surface Complement Receptor Number

1988 • 15 citations

Profile of Complement Components in Patients with Severe Burns

1980 • 15 citations

The role of heparin in guinea pig gram negative bacterial sepsis

1983 • 13 citations

Effect of soluble complement receptor type 1 on natural antibody levels during xenograft rejection.

1992 • 12 citations

Effect of anticomplement reagents, K-76 COOH and FUT175, on discordant xenograft survival.

1992 • 9 citations

Coagulation increases neutrophil CR1 and CR3 expression: primary role for platelet-derived growth factor.

1989 • 5 citations