Leukocyte Adhesion Molecules Deficiency: Its Structural Basis, Pathophysiology and Implications for Modulating the Inflammatory Response

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

Mac‐1: a macrophage differentiation antigen identified by monoclonal antibody

1979 • 1,144 citations

Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.

1989 • 1,115 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.

1988 • 988 citations

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

1983 • 888 citations

Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1

1989 • 837 citations

Structure and function of the leukocyte adhesion molecules CD11/CD18

1990 • 785 citations

A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family

1989 • 680 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion.

1988 • 650 citations

The Severe and Moderate Phenotypes of Heritable Mac-1, LFA-1 Deficiency: Their Quantitative Definition and Relation to Leukocyte Dysfunction and Clinical Features

1985 • 644 citations

ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM

1988 • 631 citations

An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism.

1986 • 593 citations

Antigens on human monocytes identified by monoclonal antibodies.

1981 • 583 citations

ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells

1988 • 580 citations

A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins

1989 • 568 citations

The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response

1988 • 533 citations

Cloning of a lymphocyte homing receptor reveals a lectin domain

1989 • 522 citations

Cloning of the $beta; subunit of the leukocyte adhesion proteins: Homology to an extracellular matrix receptor defines a novel supergene family

1987 • 520 citations

Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α

1989 • 495 citations

Complement receptor type three (CD11b/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen.

1988 • 457 citations

A monoclonal antibody to the adherence-promoting leukocyte glycoprotein, CD18, reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits.

1988 • 434 citations

Membrane complement receptor type three (CR3) has lectin-like properties analogous to bovine conglutinin as functions as a receptor for zymosan and rabbit erythrocytes as well as a receptor for iC3b.

1985 • 433 citations

Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils

1989 • 429 citations

Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies.

1986 • 423 citations

Localization of an Arg-Gly-Asp Recognition Site Within an Integrin Adhesion Receptor

1988 • 402 citations

Induction and detection of a human endothelial activation antigen in vivo.

1986 • 378 citations

Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen.

1988 • 374 citations

Heterogeneous mutations in the β subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency

1987 • 373 citations

Receptors compete for adaptors found in plasma membrane coated pits.

1988 • 366 citations

Colony-stimulating factor-1 receptor

1990 • 362 citations

A novel vitronectin receptor integrin (αvβx) is responsible for distinct adhesive properties of carcinoma cells

1989 • 352 citations

The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain.

1989 • 343 citations

Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium.

1988 • 333 citations

Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits.

1989 • 321 citations

A human lymphocyte‐associated antigen involved in cell‐mediated lympholysis

1983 • 315 citations

A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.

1989 • 314 citations

An Inherited Abnormality of Neutrophil Adhesion

1980 • 306 citations

Definition of a common leukocyte cell-surface antigen (Lp95-150) associated with diverse cell-mediated immune functions.

1983 • 305 citations

Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol).

1983 • 303 citations

Evidence for distinct intracellular pools of receptors for C3b and C3bi in human neutrophils.

1985 • 291 citations

Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium.

1989 • 288 citations

Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing.

1981 • 287 citations

Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.

1989 • 285 citations

Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins on mature granulocytes.

1986 • 284 citations

The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.

1988 • 281 citations

The saturable high affinity association of factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor.

1988 • 279 citations

cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.

1987 • 277 citations

Abnormalities of polymorphonuclear leukocyte function associated with a heritable deficiency of high molecular weight surface glycoproteins (GP138): common relationship to diminished cell adherence.

1984 • 273 citations

Fibronectin and serum amyloid P component stimulate C3b- and C3bi-mediated phagocytosis in cultured human monocytes.

1983 • 273 citations

Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel.

1989 • 270 citations

Neutrophil Actin Dysfunction and Abnormal Neutrophil Behavior

1974 • 266 citations

Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains

1983 • 265 citations

Electron microscopy and structural model of human fibronectin receptor.

1988 • 265 citations

Increased Expression of an Adhesion-Promoting Surface Glycoprotein in the Granulocytopenia of Hemodialysis

1985 • 265 citations

Role of the adherence-promoting receptors, CR3, LFA-1, and p150,95, in binding of Histoplasma capsulatum by human macrophages.

1987 • 259 citations

Aggregation of complement receptors on human neutrophils in the absence of ligand.

1987 • 250 citations

Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets.

1989 • 250 citations

Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion.

1984 • 249 citations

A monoclonal antibody (NKI-L16) directed against a unique epitope on the alpha-chain of human leukocyte function-associated antigen 1 induces homotypic cell-cell interactions.

1988 • 248 citations

T lymphocyte adhesion to endothelial cells: mechanisms demonstrated by anti-LFA-1 monoclonal antibodies.

1986 • 246 citations

Complement receptor type 3 (CR3) binds to an Arg-Gly-Asp-containing region of the major surface glycoprotein, gp63, of Leishmania promastigotes.

1988 • 242 citations

The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit.

1988 • 238 citations

A novel calcium binding site in the galactose-binding protein of bacterial transport and chemotaxis

1987 • 238 citations

Inhibition of murine T cell‐mediated cytolysis and T cell proliferation by a rat monoclonal antibody immunoprecipitating two lymphoid cell surface polypeptides of 94000 and 180000 molecular weight

1982 • 237 citations

Dynamic membrane-cytoskeletal interactions: specific association of integrin and talin arises in vivo after phorbol ester treatment of peripheral blood lymphocytes.

1988 • 230 citations

Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils.

1987 • 229 citations

LFA-1, LFA-2, and LFA-3 antigens are involved in CTL-target conjugation.

1984 • 227 citations

Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes.

1984 • 224 citations

Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules.

1989 • 218 citations

The primary structure of the beta-subunit of the cell surface adhesion glycoproteins LFA-1, CR3 and p150,95 and its relationship to the fibronectin receptor.

1987 • 215 citations

Vinculin, a cytoskeletal substrate of protein kinase C.

1983 • 215 citations

Two leukocyte receptors (CD11a/CD18 and CD11b/CD18) mediate transient adhesion to endothelium by binding to different ligands.

1989 • 204 citations

cDNA sequences for human von Willebrand factor reveal five types of repeated domains and five possible protein sequence polymorphisms

1986 • 204 citations

The effect of anti-intercellular adhesion molecule-1 on phorbol-ester-induced rabbit lung inflammation.

1989 • 201 citations

Deficiency of a surface membrane glycoprotein (Mo1) in man.

1984 • 192 citations

Heterogeneity of clonogenic cells in acute myeloblastic leukemia.

1985 • 187 citations

Leukocyte adhesion deficiency: molecular basis and functional consequences.

1988 • 186 citations

Model for Leukocyte Regulation by Chemoattractant Receptors: Roles of a Guanine Nucleotide Regulatory Protein and Polyphosphoinositide Metabolism

1986 • 181 citations

Deficiency of a Granulocyte-Membrane Glycoprotein (gp150) in a Boy with Recurrent Bacterial Infections

1982 • 180 citations

Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies.

1986 • 174 citations

Structure-function relationship of human von Willebrand factor

1987 • 164 citations

LFA-1 immunodeficiency disease. Definition of the genetic defect and chromosomal mapping of alpha and beta subunits of the lymphocyte function-associated antigen 1 (LFA-1) by complementation in hybrid cells.

1986 • 163 citations

Relative contribution of the leukocyte molecules MO1, LFA‐1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue‐ and stimulus‐specific

1988 • 162 citations

Amino acid sequence of the murine Mac-1 alpha chain reveals homology with the integrin family and an additional domain related to von Willebrand factor.

1988 • 160 citations

Role of p150,95 in adhesion, migration, chemotaxis and phagocytosis of human monocytes

1987 • 158 citations

Heterogeneous distribution and transmembrane signaling properties of lymphocyte function-associated antigen (LFA-1) in human lymphocyte subsets.

1989 • 158 citations

Dissociation between increased surface expression of gp165/95 and homotypic neutrophil aggregation.

1988 • 156 citations

Leukocyte Adhesion Deficiency

1989 • 153 citations

The human lymphocyte function-associated (HLFA) antigen and a related macrophage differentiation antigen (HMac-1): functional effects of subunit-specific monoclonal antibodies.

1985 • 152 citations

pl50/95, Third member of the LFA‐1/CR₃ polypeptide family identified by anti‐Leu M5 monoclonal antibody

1985 • 149 citations

DELAYED SEPARATION OF THE UMBILICAL CORD, WIDESPREAD INFECTIONS, AND DEFECTIVE NEUTROPHIL MOBILITY

1979 • 143 citations

CD11a-c/CD18 and GP84 (LB-2) adhesion molecules on human large granular lymphocytes and their participation in natural killing.

1988 • 143 citations

Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mo1 (complement receptor type 3).

1988 • 140 citations

Identification of a Cell Surface Protein Complex Mediating Phorbol Ester‐Induced Adhesion (Binding) among Human Mononuclear Leukocytes

1985 • 139 citations

Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16.

1989 • 138 citations

Transmembrane signalling via the T11‐dependent pathway of human T cell activation. Evidence for the involvement of 1,2‐diacylglycerol and inositol phosphates

1987 • 137 citations

ABSENCE OF MONOCLONAL-ANTIBODY-DEFINED PROTEIN COMPLEX IN BOY WITH ABNORMAL LEUCOCYTE FUNCTION

1984 • 135 citations

Structure-function relationship of human von Willebrand factor

1987 • 131 citations

ABSENCE OF CELL SURFACE LFA-1 AS A MECHANISM OF ESCAPE FROM IMMUNOSURVEILLANCE

1987 • 129 citations

THE DEPRESSION OF PHAGOCYTOSIS BY EXOGENOUS CYCLIC NUCLEOTIDES, PROSTAGLANDINS, AND THEOPHYLLINE

1973 • 129 citations

Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1.

1981 • 126 citations

Differential expression of CD11b/CD18 (Mo1) and myeloperoxidase genes during myeloid differentiation

1989 • 124 citations

Kinases and phosphatases in T-cell activation

1989 • 118 citations

Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion.

1988 • 112 citations

Interaction of target cell-bound C3bi and C3d with human lymphocyte receptors. Enhancement of antibody-mediated cellular cytotoxicity.

1981 • 109 citations

Cyclic Nucleotide Changes in Human Neutrophils Induced by Chemoattractants and Chemotactic Modulators

1977 • 108 citations

BONE-MARROW TRANSPLANTATION FOR INBORN ERROR OF PHAGOCYTIC CELLS ASSOCIATED WITH DEFECTIVE ADHERENCE, CHEMOTAXIS, AND OXIDATIVE RESPONSE DURING OPSONISED PARTICLE PHAGOCYTOSIS

1983 • 106 citations

Identification of a novel adhesion molecule in human leukocytes by monoclonal antibody LB‐2

1987 • 103 citations

Structural features of cartilage matrix protein deduced from cDNA.

1987 • 101 citations

Characterization of patients with an increased susceptibility to bacterial infections and a genetic deficiency of leukocyte membrane complement receptor type 3 and the related membrane antigen LFA-1

1985 • 98 citations

Abnormal stimulated adherence of neonatal granulocytes: impaired induction of surface Mac-1 by chemotactic factors or secretagogues

1987 • 96 citations

Ligand binding by the pl50,95 antigen of U937 monocytic cells: properties in common with complement receptor type 3 (CR3)

1986 • 93 citations

LFA-1 membrane molecule in the regulation of homotypic adhesions of human B lymphocytes.

1985 • 93 citations

Phosphorylation of the cytoskeletal protein talin by protein kinase C

1986 • 93 citations

Ontogeny of human hematopoietic cells: analysis utilizing monoclonal antibodies.

1983 • 91 citations

Identification of cell surface antigens present on murine hematopoietic stem cells.

1985 • 87 citations

SERUM-DEPENDENT PHAGOCYTOSIS OF PARAFFIN OIL EMULSIFIED WITH BACTERIAL LIPOPOLYSACCHARIDE

1973 • 83 citations

Human neutrophil gelatinase is a component of specific granules.

1989 • 77 citations

Deficiency of the adhesive protein complex lymphocyte function antigen 1, complement receptor type 3, glycoprotein p150,95 in a girl with recurrent bacterial infections. Effects on phagocytic cells and lymphocyte functions.

1985 • 75 citations

Influence of quaternary structure on glycosylation. Differential subunit association affects the site-specific glycosylation of the common beta-chain from Mac-1 and LFA-1.

1986 • 74 citations

Interferon-gamma induction of LFA-1-mediated homotypic adhesion of human monocytes.

1986 • 72 citations

Functional role of the alpha-chain of complement receptor type 3 in human eosinophil-dependent antibody-mediated cytotoxicity against schistosomes.

1987 • 71 citations

Leukocytes from four patients with complete or partial Leu-CAM deficiency contain the common beta-subunit precursor and beta-subunit messenger RNA.

1987 • 71 citations

Leukocyte Adhesion Deficiency: An Inherited Defect In The Mac-1, LFA-1, And p150,95 Glycoproteins

1987 • 66 citations

The genetic deficiency of leukocyte surface glycoprotein Mac-1, LFA-1, p150,95 in humans is associated with defective antibody-dependent cellular cytotoxicity in vitro and defective protection against herpes simplex virus infection in vivo.

1986 • 63 citations

The Effect of 3′,5′-Adenosine Monophosphate on Granulocyte Adhesion

1974 • 63 citations

Defective initiation of the metabolic stimulation in phagocytizing granulocytes: a new congenital defect.

1976 • 62 citations

Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac-1 (complement receptor type 3).

1987 • 62 citations

Modulation of surface glycoproteins (Mo1, LFA-1, p150,95) by human mononuclear phagocytes

1988 • 61 citations

Lectures on General Pathology

1954 • 61 citations

The role of cell surface recognition structures in the initiation of MHC-unrestricted ‘promiscuous’ killing by T cells

1989 • 57 citations

Absence, or low expression, of leukocyte adhesion molecules CDI1 and CD18 on burkjtt lymphoma cells

1988 • 57 citations

Expression of leukocyte adherence-related glycoproteins during differentiation of HL-60 promyelocytic leukemia cells.

1987 • 55 citations

Studies on antigens associated with the activation of murine mononuclear phagocytes: kinetics of and requirements for induction of lymphocyte function-associated (LFA)-1 antigen in vitro.

1985 • 55 citations

Isolation and characterization of a 33,000-dalton fragment of complement Factor B with catalytic and C3b binding activity.

1984 • 55 citations

Recurrent infections and delayed separation of the umbilical cord in an infant with abnormal phagocytic cell locomotion and oxidative response during particle phagocytosis

1981 • 53 citations

Somatic gene therapy. Current status and future prospects.

1986 • 49 citations

Complement C3 receptors: Structure and function

1984 • 46 citations

The elevated natural killer sensitivity of targets carrying surface-attached C3 fragments require the availability of the iC3b receptor (CR3) on the effectors.

1988 • 45 citations

Adhesion-mediating molecules of human monocytes

1988 • 43 citations

Treatment of rabbit neutrophils with phorbol esters results in increased ADP‐ribosylation catalyzed by pertussis toxin and inhibition of the GTPase stimulated by fMet‐Leu‐Phe

1986 • 42 citations

Recurrent severe infections in a child with abnormal leukocyte function: possible relationship to increased microtubule assembly

1978 • 42 citations

Lymphocyte function-associated antigen 1 (LFA-1) contains sulfated N-linked oligosaccharides.

1985 • 42 citations

LFA‐1 β‐chain synthesis and degradation in patients with leukocyte‐adhesive proteins deficiency

1987 • 37 citations

Multimeric C9 within C5b-9 is required for inner membrane damage to Escherichia coli J5 during complement killing.

1987 • 36 citations

Increased intracellular cyclic adenosine monophosphate inhibits T lymphocyte-mediated cytolysis by two distinct mechanisms.

1988 • 33 citations

Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins.

1988 • 33 citations

The expression of CD18 is increased on Trisomy 21 (Down syndrome) lymphoblastoid cells.

1988 • 31 citations

cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits.

1989 • 31 citations

Negative effect of a protein kinase C inhibitor (H-7) on human polymorphonuclear neutrophil locomotion.

1988 • 28 citations

FAILURE OF A CD18/ANTI-LFAl MONOCLONAL ANTIBODY PATIENTS RECEIVING T-DEPLETED ALLOGENEIC BONE INFUSION TO PREVENT GRAFT REJECTION IN LEUKEMIC MARROW TRANSPLANTATION

1989 • 25 citations

Phorbol Ester-induced Adhesion (binding) among Human Mononuclear Leukocytes Requires Extracellular Mg++ and is Sensitive to Protein Kinase C, Lipoxygenase, and ATPase Inhibitors

1985 • 21 citations

Glycoprotein-180 deficiency: genetics and abnormal neutrophil activation

1985 • 20 citations

Abnormal cytolytic activity of lymphocyte function-associated antigen-1-deficient human cytolytic T lymphocyte clones.

1986 • 19 citations

Macrophage component gp160, a major trypsin-sensitive surface glycoprotein.

1980 • 18 citations

NEW FAMILIAL DEFECT IN MICROBICIDAL FUNCTION OF POLYMORPHONUCLEAR LEUCOCYTES

1975 • 18 citations

The relationship between CR3 deficiency and neutrophil actin assembly

1989 • 18 citations

STUDIES OF UREA EXCRETION. VII THE EFFECTS OF POSTURE AND EXERCISE ON UREA EXCRETION

1932 • 16 citations

Neutrophil Adhesion Abnormality with Deficient Surface Membrane Proteins (gp 110 and p 98): The Effect of their Antibodies on the Function of Normal Neutrophils

1986 • 10 citations

Fc-receptor mediated protein phosphorylation in murine peritoneal macrophages

1984 • 10 citations

A dysfunctional Mo1 glycoprotein is present on a subline of the KG1 acute myelogenous leukemia cell line.

1987 • 2 citations