Receptor class desensitization of leukocyte chemoattractant receptors.

Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA

1985 • 2,505 citations

DNA cloning : a practical approach

1985 • 2,302 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Genetic engineering. Principles and methods

1987 • 715 citations

The chemotactic receptor for human C5a anaphylatoxin

1991 • 660 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

A family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 636 citations

Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung

1991 • 594 citations

Fluorescence and bioluminescence measurement of cytoplasmic free calcium

1987 • 522 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Signal transduction by guanine nucleotide binding proteins

1987 • 362 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors

1990 • 323 citations

Role of phosphorylation in desensitization of the β-adrenoceptor

1990 • 300 citations

Adp-Ribosylating Toxins and G Proteins: Insights into Signal Transduction

1990 • 285 citations

Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction.

1985 • 281 citations

Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule

1986 • 275 citations

The role of cyclic AMP in the chemotactic responsiveness and spontaneous motility of rabbit peritoneal neutrophils. The inhibition of neutrophil movement and the elevation of cyclic AMP levels by catecholamines, prostaglandins, theophylline and cholera toxin.

1975 • 271 citations

Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.

1990 • 270 citations

Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA

1990 • 254 citations

Mechanisms of action of calcium‐mobilizing agonists: some variations on a young theme

1988 • 236 citations

Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.

1987 • 235 citations

Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes

1985 • 229 citations

Induction of a transient elevation in intracellular levels of adenosine-3',5'-cyclic monophosphate by chemotactic factors: an early event in human neutrophil activation.

1980 • 221 citations

Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells.

1985 • 197 citations

Phorbol esters inhibit the fMet-Leu-Phe- and leukotriene B4-stimulated calcium mobilization and enzyme secretion in rabbit neutrophils.

1985 • 196 citations

Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.

1987 • 184 citations

The dynamics of ligand-receptor interactions. Real-time analyses of association, dissociation, and internalization of an N-formyl peptide and its receptors on the human neutrophil.

1984 • 178 citations

Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling.

1985 • 175 citations

Inhibitory effect of prostaglandin E2, forskolin, and dibutyryl cAMP on arachidonic acid release and inositol phospholipid metabolism in guinea pig neutrophils.

1986 • 164 citations

Receptor-cytoskeleton interactions and membrane traffic may regulate chemoattractant-induced superoxide production in human granulocytes.

1986 • 144 citations

Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells.

1988 • 144 citations

The receptors for ATP and fMetLeuPhe are independently coupled to phospholipases C and A2 via G-protein(s). Relationship between phospholipase C and A2 activation and exocytosis in HL60 cells and human neutrophils

1989 • 123 citations

Hormonal regulation of Gi2 α-subunit phosphorylation in intact hepatocytes

1990 • 117 citations

Agents That Increase Cyclic AMP Inhibit Accumulation of cGMP and Depress Human Monocyte Locomotion

1978 • 109 citations

Genetic engineering. Principles and methods

1987 • 105 citations

Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes

1990 • 95 citations

ATP induces transient elevations of [Ca2+]i in human neutrophils and primes these cells for enhanced O2- generation.

1988 • 95 citations

The fate of an N-formylated chemotactic peptide in stimulated human granulocytes. Subcellular fractionation studies.

1983 • 82 citations

Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides

1989 • 76 citations

Molecular cloning of a new human G protein Evidence for two G_iα‐like protein families

1987 • 70 citations

Stimulus-specific deactivation of chemotactic factor-induced cyclic AMP response and superoxide generation by human neutrophils.

1980 • 69 citations

Identification of the polymorphonuclear leukocyte C5a receptor.

1985 • 67 citations

In Vivo Receptor-Mediated Phosphorylation of a G Protein in Dictyostelium

1990 • 55 citations

Independent regulation of human neutrophil chemotactic receptors after activation.

1987 • 46 citations

Nucleotide responses of human neutrophils.

1991 • 35 citations

Desensitization uncouples the formyl peptide receptor-guanine nucleotide-binding protein interaction in HL60 cells.

1989 • 35 citations

The Chemotactic Peptide Receptor: A Model for Future Understanding of Chemotactic Disorders

1988 • 29 citations

Guanine nucleotide regulatory proteins in receptor-mediated polyphosphoinositide hydrolysis in human leukocytes

1987 • 9 citations