Alterations in Gene Expression with Aging

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

Capping of eucaryotic mRNAs

1976 • 1,141 citations

The Inheritance of Epigenetic Defects

1987 • 1,058 citations

THE MAINTENANCE OF THE ACCURACY OF PROTEIN SYNTHESIS AND ITS RELEVANCE TO AGEING

1963 • 950 citations

Handbook of the Biology of Aging

1986 • 572 citations

Cellular senescence and DNA synthesis

1973 • 537 citations

Determinants of messenger RNA stability

1987 • 414 citations

Ubiquitin-Mediated Pathways for Intracellular Proteolysis

1987 • 409 citations

Human skin fibroblasts in vitro differentiate along a terminal cell lineage.

1988 • 400 citations

The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells

1982 • 356 citations

Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin

1988 • 345 citations

EXTRALYSOSOMAL PROTEIN DEGRADATION

1986 • 279 citations

Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors.

1988 • 257 citations

Glucocorticoids enhance stability of human growth hormone mRNA.

1987 • 250 citations

Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts.

1986 • 247 citations

Peptide sequences that target proteins for enhanced degradation during serum withdrawal.

1988 • 238 citations

Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain

1987 • 237 citations

Protein turnover and growth in the whole body, liver and kidney of the rat from the foetus to senility

1984 • 226 citations

The ubiquitin‐mediated proteolytic pathway and mechanisms of energy‐dependent intracellular protein degradation

1984 • 221 citations

Existence of High Abundance Antiproliferative mRNA's in Senescent Human Diploid Fibroblasts

1986 • 194 citations

Vasopressin mRNA in the Suprachiasmatic Nuclei: Daily Regulation of Polyadenylate Tail Length

1988 • 172 citations

Genetic instability as the primary cause of human aging

1986 • 143 citations

Translational control during early dictyostelium development: Possible involvement of poly(A) sequences

1984 • 141 citations

Relationship between Metabolic Rate, Free Radicals, Differentiation and Aging: A Unified Theory

1985 • 127 citations

A 57,000-mol-wt protein uniquely present in nonproliferating cells and senescent human fibroblasts.

1985 • 125 citations

Newly formed mRNA lacking polyadenylic acid enters the cytoplasm and the polyribosomes but has a shorter half-life in the absence of polyadenylic acid.

1982 • 108 citations

A profusion of controls.

1988 • 107 citations

Influence of 5'-terminal cap structure on the initiation of translation of vaccinia virus mRNA.

1978 • 101 citations

Isolation and characterization of human elastin cDNAs, and age-associated variation in elastin gene expression in cultured skin fibroblasts.

1988 • 99 citations

Age-dependent relaxation of gene repression: Increase of endogenous murine leukemia virus-related and globin-related RNA in brain and liver of mice

1978 • 96 citations

Behavior of indivdual maternal pA+ RNAs during embryogenesis of Xenopus laevis

1982 • 88 citations

Effect of age and dietary restriction on the expression of alpha 2u-globulin.

1987 • 85 citations

The effect of aging on the expression of interleukin 2 messenger ribonucleic acid

1986 • 85 citations

Antioxidants and Longevity of Mammalian Species

1985 • 84 citations

EFFECTS OF AGEING ON LOCAL RATES OF CEREBRAL PROTEIN SYNTHESIS IN SPRAGUE-DAWLEY RATS

1985 • 81 citations

Rapid disappearance of statin, a nonproliferating and senescent cell-specific protein, upon reentering the process of cell cycling.

1985 • 79 citations

Senescent and quiescent cell inhibitors of DNA synthesis

1985 • 79 citations

Mature mRNA is selectively released from the nuclear matrix by an ATP/dATP-dependent mechanism sensitive to topoisomerase inhibitors.

1987 • 73 citations

Regulation of ornithine decarboxylase and other cell cycle-dependent genes during senescence of IMR-90 human diploid fibroblasts.

1988 • 73 citations

A soluble ATP-dependent system for protein degradation from murine erythroleukemia cells. Evidence for a protease which requires ATP hydrolysis but not ubiquitin.

1985 • 70 citations

Membrane-associated inhibitor of DNA synthesis in senescent human diploid fibroblasts: characterization and comparison to quiescent cell inhibitor.

1986 • 69 citations

Programmed aging or error catastrophe? An exmination by two-dimensional polyacrylamide gel electrophoresis

1985 • 66 citations

Vasoactive Intestinal Peptide Gene Expression from Embryos to Aging Rats

1988 • 64 citations

Aging results in an unusual expression of Drosophila heat shock proteins.

1988 • 62 citations

Age-Dependent Changes in Proteins of Drosophila melanogaster

1986 • 61 citations

c-Ha-ras-1 proto-oncogene amplification and overexpression during the limited replicative life span of normal human fibroblasts.

1985 • 60 citations

Decline in synthesis of elongation factor one (EF-1) precedes the decreased synthesis of total protein in aging Drosophila melanogaster

1983 • 59 citations

Effect of Dietary Restriction on Liver Protein Synthesis in Rats

1985 • 58 citations

Centrophenoxine increases the rates of total and mRNA synthesis in the brain cortex of old rats: An explanation of its action in terms of the membrane hypothesis of aging

1984 • 57 citations

Effects of donor age on protein and collagen synthesis in vitro by human diploid fibroblasts.

1986 • 57 citations

Brain Poly(A)RNA During Aging: Stability of Yield and Sequence Complexity in Two Rat Strains

1980 • 52 citations

Differential regulation of the messenger RNA for three major senescence marker proteins in male rat liver.

1981 • 49 citations

Inhibition of DNA synthesis in proliferating human diploid fibroblasts by fusion with senescent cytoplasts*1

1983 • 49 citations

Age-Related Decrease of Growth Hormone and Prolactin Gene Expression in the Mouse Pituitary*

1987 • 47 citations

Effect of age and dietary restriction on protein synthesis by isolated kidney cells

1985 • 44 citations

Inhbition of DNA synthesis in young cycling human diploid fibroblast-like cells upon fusion to enucleate cytoplasts from senescent cells

1983 • 44 citations

Age-dependence of nuclear RNA processing

1977 • 44 citations

The effects of ageing and chronic dietary restriction on in vivo hepatic protein synthesis in the rat

1987 • 43 citations

In vivo studies on the age-dependent decrease of the rates of total and mRNA synthesis in the brain cortex of rats

1982 • 42 citations

Expression of interleukin 2 and the interleukin 2 receptor in aging rats

1989 • 41 citations

Lowered rates of protein synthesis by mitochondria isolated from organisms of increasing age

1984 • 41 citations

Altered degradation of intracellular proteins in aging human fibroblasts

1984 • 38 citations

Defective T lymphocytes in old mice. Diminished production of mature c-myc RNA after mitogen exposure not attributable to alterations in transcription or RNA stability.

1988 • 37 citations

Decreased rates of protein synthesis by cell-free preparations from different organs of aging mice

1983 • 36 citations

EGF‐dependent phosphorylation of the EGF receptor in plasma membranes isolated from young and senescent WI‐38 cells

1987 • 36 citations

Constancy of ribosomal RNA genes during aging of mouse heart cells and during serial passage of WI-38 cells

1984 • 35 citations

Specific disappearance of translatable messenger RNA for elongation factor one in aging Drosophila melanogaster

1984 • 35 citations

Changes in transcriptional activity and matrix association of α2u-globulin gene family in the rat liver during maturation and aging

1988 • 35 citations

Activity Patterns of Aminoacyl‐tRNA Synthetases, tRNA Methylases, Arginyltransferase and Tubulin: Tyrosine Ligase during Development and Ageing of Caenorhabditis elegans

1983 • 33 citations

Codon recognition fidelity of ribosomes at the first and second positions does not decrease during aging

1983 • 32 citations

Absence of gross change in primary DNA sequence during aging process of mice

1985 • 32 citations

Age‐related changes in different steps of protein synthesis of liver and kidney of rats

1983 • 31 citations

Age-dependent gene induction in quail oviduct. XV. Alterations of the poly(A)-associated protein pattern and of the poly(A) chain lenght of mRNA

1982 • 31 citations

Selective elevation of C-MYC transcript levels in the liver of the aging Fischer-344 rat

1987 • 29 citations

Superoxide radical-induced loss of nuclear restriction of immature mRNA: A possible cause for ageing

1987 • 29 citations

Turnover of 3'-polyadenylate-containing RNA in livers from aged, partially hepatectomized, neonatal, and Morris 5123C hepatoma-bearing rats.

1980 • 29 citations

Effect of age on peptide chain initiation and elongation in preparations from brain, liver, kidney and skeletal muscle of the C57B1/6J mouse

1984 • 27 citations

Changes in protein synthesis and breakdown rates and responsiveness to growth factors with ageing in human lung fibroblasts

1985 • 27 citations

Changes in the sequence content of albumin mRNA and in its translational activity in the rat liver with age

1984 • 27 citations

Protein Synthesis Studies in Skeletal Muscle of Aging Rats. I. Alterations in Nitrogen Composition and Protein Synthesis Using a Crude Polyribosome and pH 5 Enzyme System

1984 • 26 citations

Translation fidelity in the aging mammal: Studies with an accurate in vitro system on aged rats

1985 • 25 citations

Regional analysis of rat brain proteins during senescence

1987 • 25 citations

Dysdifferentiative Nature of Aging: Age-Dependent Expression of MuLV and Globin Genes in Thymus, Liver and Brain in the AKR Mouse Strain

1985 • 24 citations

Expression of c-myc oncogene in human fibroblasts during senescence

1986 • 22 citations

Age dependent changes in the expression of Drosophila mitochondrial proteins

1986 • 22 citations

The Two-dimensional polypeptide profile of terminally non-dividing human diploid cells*1

1984 • 21 citations

Decreased Transcription of Neuronal Polyadenylated RNA During Senescence in Nuclei from Rat Brain Cortex

1986 • 21 citations

Functional deterioration of mouse liver ribosomes during aging: Translational activity and activity for formation of the 47 S initiation complex

1984 • 21 citations

Differential polyadenylation pattern of ovalbumin precursor RNAs during development

1986 • 21 citations

Protein turnover and cathepsin B activity in several individual tissues of foetal and senescent rats

1985 • 21 citations

Dysdifferentiative Nature of Aging: Passage Number Dependency of Globin Gene Expression in Normal Human Diploid Cells Grown in Tissue Culture

1985 • 20 citations

Reversal of age-related effects in rat muscle phosphoglycerate kinase.

1987 • 20 citations

mRNA population in the liver, kidney and brain of young and senescent mice: Analysis of in vitro translation products

1983 • 19 citations

Organ pattern of age-related changes in the aminoacyl-tRNA synthetase activities of the mouse

1982 • 19 citations

Isolated uterine nuclei and cytosol receptors of aged rats exhibit impaired estrogenic stimulation of RNA polymerase II.

1984 • 19 citations

The Transcription of Various Types of Ribonucleic Acid by Hepatocytes Isolated From Rats of Various Ages

1982 • 18 citations

The Proportion of Ribosomes Active in Protein Synthesis and the Content of Polyribosomal Poly(A)-Containing RNA in Adult and Senescent Rat Livers

1979 • 18 citations

Occurrence of short-sized oligo(A) fragments during course of cell cycle and ageing

1983 • 17 citations

Effect of advanced age on the induction by androgen or thyroid hormone of epidermal growth factor and epidermal growth factor mRNA in the submandibular glands of C57BL/6 male mice

1986 • 16 citations

The effect of aging on the structure and function of liver messenger RNA

1985 • 16 citations

The effect of aging on cell-free protein synthesis in the free-living nematode Turbatrix aceti☆

1985 • 16 citations

Alteration of enzymes in ageing human fibroblasts in culture. II. Conditions for the reversibility and the mechanism of the alteration of glucose 6-phosphate dehydrogenase

1984 • 16 citations

The content and size distribution of membrane-bound and free polyribosomes in mouse liver during aging

1984 • 15 citations

Age-specific nuclear proteins in the nematode worm Caenorhabditis elegans

1987 • 15 citations

Protein Variations Associated with in Vitro Aging of Human Fibroblasts and Quantitative Limits on the Error Catastrophe Hypothesis

1983 • 15 citations

Altered sensitivity of protein synthesis to paromomycin in extracts from aging human diploid fibroblasts

1987 • 14 citations

The synthesis of amylase in parotid glands of young and old rats

1985 • 14 citations

Altered phosphoglycerate kinase from old rat muscle shows no change in primary structure

1985 • 14 citations

The effect of age on the induction of tyrosine aminotransferase and tryptophan oxygenase genes by physiological stress

1986 • 14 citations

Effect of aging on human aortic protein composition

1985 • 14 citations

Cellular and molecular aspects of thymus dependent antibody production in aged C3H/HeBr mice

1983 • 14 citations

Failure in S6 protein phosphorylation by serum stimulatio of senescent human diploid fibroblasts, TIG-1

1986 • 13 citations

Evidence for age-dependent impairment of ovalbumin heterogeneous nuclear RNA (HnRNA) processing in hen oviduct

1985 • 13 citations

Changes in protein turnover and growth of the rat lung in response to ageing and long-term dietary restriction

1988 • 13 citations

Protein synthesis by liver ribosomes from aged rats

1986 • 13 citations

Regenerating Liver in Aged Rats Produces Unaltered Phosphoglycerate Kinase

1982 • 13 citations

Transcription in aging: The response of rat liver nuclear RNA polymerases to cycloheximide in vivo

1982 • 12 citations

Degradation of peptides and proteins of different sizes by homogenates of human MRC5 lung fibroblasts

1985 • 12 citations

Modified composition of major ontogenetically regulated mRNAs and proteins in the cerebellum of old and of staggerer mice

1983 • 12 citations

Effect of inhibitors and stimulators on isolated liver cell mitochondrial protein synthesis from young and old rats

1982 • 11 citations

Heat shock-related decline in activity and amounts of active elongation factor 1α in ageing and immortal human cells

1988 • 11 citations

C-Ras expression decreases during invitro senescence in human fibroblasts

1986 • 11 citations

Comparison of proto oncogene expression in seven primate fibroblast cultures

1987 • 11 citations

Age related changes in total DNA and RNA and incorporation of uridine and thymidine in rat brain

1983 • 10 citations

Encephalomyocarditis virus as a probe of errors in macromolecular synthesis in aging mice

1982 • 10 citations

Absence of age differences in protein synthesis by rat brain, measured with an initiating cell-free system

1987 • 10 citations

The effect of age and diet on the cellular protein synthesis of liver of male mice

1987 • 9 citations

The complement of cytoplasmic tRNAs, including queuosine-containing tRNAs, in adult and senescent wistar rat liver and their levels of aminoacylation

1982 • 8 citations

Effect of Short-Term Physical Stress on DNA and Collagen Synthesis in the Femur of Young and Old Mice

1987 • 8 citations

Protein Synthesis Studies in Skeletal Muscle of Aging Rats. II. In Vitro Studies With 0.5M Potassium Chloride Washed Polyribosomes

1984 • 7 citations

Age-related changes in total dna and rna and incorporation of uridine and thymidine in rat liver, kidney and spleen

1983 • 6 citations

Heterogeneity of protein synthesis initiation factors in developing and aging rat brain

1984 • 5 citations

Age dependent changes in the activity of the cytosolic fraction from rat liver to stimulate polysomal protein synthesis and the role of initiation factor eIF-2.

1987 • 4 citations

Estimation of the turnover rates of 3H-uridine in mouse skeletal tissues during aging

1981 • 4 citations

Stimulation of nuclear RNA polymerase I activity by a soluble factor isolated from young rat liver nuclei

1983 • 2 citations

Deleted Work

1955 • 0 citations