The effect of aging on the expression of interleukin 2 messenger ribonucleic acid

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

Structure and expression of a cloned cDNA for human interleukin-2

1983 • 1,176 citations

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

Age Influence on the Immune System

1980 • 703 citations

Pathological Changes During Aging in, Barrier-Reared Fischer 344 Male Rats

1977 • 526 citations

Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans.

1981 • 473 citations

Induction of Interleukin 2 Messenger RNA Inhibited by Cyclosporin A

1984 • 404 citations

Lymphokines and aging: interleukin-2 production and activity in aged animals.

1981 • 234 citations

T-cell-derived helper factor allows in vivo induction of cytotoxic T cells in nu/nu mice

1980 • 228 citations

Biochemical characterization of lymphocyte regulatory molecules. II. Purification of a class of rat and human lymphokines.

1980 • 210 citations

Mitogenic Effect of Phytohaemagglutinin at Different Ages

1967 • 204 citations

Heterogeneity of human T-cell growth factor(s) due to variable glycosylation

1981 • 193 citations

Role of T cells and adherent cells in age-related decline in murine interleukin 2 production.

1982 • 153 citations

Age-associated decline in precursor frequency for different T cell-mediated reactions, with preservation of helper or cytotoxic effect per precursor cell.

1984 • 140 citations

Immunologic studies of aging. V. Impaired proliferation of PHA responsive human lymphocytes in culture.

1980 • 116 citations

The Effect of T Cell Growth Factor on the Generation of Cytolytic T Cells

1978 • 113 citations

Continuous culture of T cells cytotoxic for autologous human leukaemia cells

1979 • 111 citations

Kinetics of induction and molecular size of mRNAs encoding human interleukin-2 and γ-interferon

1982 • 104 citations

Control of protein synthesis during the activation of lymphocytes by phytohaemagglutinin

1971 • 88 citations

Partial Purification and Molecular Characterization of a Lymphokine (Costimulator) Required for the Mitogenic Response of Mouse Thymocytes in Vitro

1978 • 86 citations

I. The relationship between age-related changes in gene expression, protein turnover, and the responsiveness of an organism to stimuli

1982 • 85 citations

Age-Related Changes in T Cell Function

1977 • 85 citations

Role of protein and RNA synthesis in the development of insulin binding sites on activated thymus-derived lymphocytes.

1979 • 80 citations

Selective reconstitution of nude mice with long-term cultured and cloned specific helper T cells

1980 • 73 citations

Phytomitogen responses of peripheral blood lymphocytes in young and older subjects.

1974 • 72 citations

Expression of receptors for interleukin 2: Role in the commitment of T lymphocytes to proliferate.

1984 • 65 citations

Age-related refractoriness of PHA-induced lymphocyte transformation. II. 125I-PHA binding to spleen cells from young and old mice

1975 • 43 citations

The control of protein synthesis during the stimulation of lymphocytes by phytohaemagglutinin

1973 • 33 citations

Age-related refractoriness of pha-induced lymphocyte transformation I. Comparable sensitivity of spleen cells from young and old mice to culture conditions

1975 • 32 citations

Mechanism of lymphocyte activation. II. Requirements for macromolecular synthesis in the production of lymphokines.

1980 • 30 citations

Carbohydrate Incorporation in Plasma Membranes of Mouse Thymocytes Stimulated by Concanavalin A

1977 • 25 citations

Lymphocyte activation in human ageing: V. Acquisition of response to T cell growth factor and production of growth factors by mitogen-stimulated lymphocytes

1983 • 22 citations

Evidence for the presence of mRNA in the post-ribosomal cytoplasm of sheep lymphocytes

1976 • 15 citations

The importance of membrane-bound ribosomes during the activation of thymocytes by concanavalin A

1976 • 11 citations