Genetic instability as the primary cause of human aging

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

ON THE NATURE OF THE AGING PROCESS

1959 • 620 citations

General Theory of Mortality and Aging

1960 • 574 citations

Changes in Cardiac Output with Age

1955 • 558 citations

Time, cells, and aging

1962 • 553 citations

Essays Upon Heredity and Kindred Biological Problems

2009 • 398 citations

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

1964 • 339 citations

Rate And Magnitude Of Age Pigment Accumulation In The Human Myocardium

1959 • 336 citations

A MOLECULAR EXPLANATION OF THE BOBBED MUTANTS OF DROSOPHILA AS PARTIAL DEFICIENCIES OF "RIBOSOMAL" DNA

1966 • 295 citations

Detection of Inactive Enzyme Molecules in Ageing Organisms

1970 • 220 citations

Essays upon heredity and kindred biological problems /

1892 • 211 citations

On the Statistical Nature of Mortality, with Especial Reference to Chronic Radiation Mortality

1956 • 169 citations

LIPOPROTEIN PIGMENTS—THEIR RELATIONSHIP TO AGEING IN THE HUMAN NERVOUS SYSTEM

1974 • 159 citations

Maturation and Longevity in Relation to Cranial Capacity in Hominid Evolution

1975 • 135 citations

Relation of Lifespan to Brain Weight and Body Weight in Mammals

2008 • 131 citations

Loss of Genes coding for Ribosomal RNA in Ageing Brain Cells

1972 • 127 citations

Unequal Mitotic Sister Chromatid Exchange and Disproportionate Replication as Mechanisms Regulating Ribosomal RNA Gene Redundancy

1974 • 125 citations

Biological mechanisms of aging

1967 • 109 citations

Origin and Comparison of the Effects of Time and High-Energy Radiations on Living Systems

1959 • 100 citations

The Biologic Effects of Pile Radiations

1947 • 98 citations

Biological Mechanisms of Aging

1963 • 95 citations

Evidence derived from sister chromatid exchanges of restricted rejoining of chromatid subunits

1975 • 91 citations

Experimental Studies on the Duration of Life. XI. Density of Population and Life Duration in Drosophila

1927 • 88 citations

The Modification by X-Irradiation of the Life Span of Haploids and Diploids of the Wasp, Habrobracon SP

1961 • 85 citations

Evolution of longevity in primates

1976 • 80 citations

Evolution of human longevity: A critical overview

1979 • 69 citations

Loss of hybridizable ribosomal DNA from human post-mitotic tissues during aging: I. Age-dependent loss in human myocardium

1979 • 66 citations

Ribosomal RNA gene dosage as a function of tissue and age for mouse and human

1976 • 62 citations

�ber die Entstehung von Lipopigmenten in Muskelfasern Untersuchungen beim experimentellen Vitamin E-Mangel der Ratte und an Organen des Menschen

1959 • 58 citations

Experimental Studies on the Duration of Life. VII. The Mendelian Inheritance of Duration of Life in Crosses of Wild Type and Quintuple Stocks of Drosophila melanogaster

1923 • 54 citations

Loss of hybridizable ribosomal DNA from human post-mitotic tissues during aging: II. Age-dependent loss in human cerebral cortex — Hippocampal and somatosensory cortex comparison

1979 • 52 citations

The number of silver-staining NORs (rDNA) in lymphocytes of newborns and its relationship to human developemnt

1986 • 51 citations

Selective loss of ribosomal RNA genes during the aging of post-mitotic tissues

1972 • 43 citations

Cardiac hypertrophy, aging and changes in cardiac ribosomal RNA gene dosage in man

1975 • 39 citations

Studies on the Comparative Physiology of Aging. III. Effects of X-Radiation Dosage on Age-Specific Mortality Rates of Drosophila Melanogaster and Campanularia Flexuosa

1964 • 37 citations

The relationship between aging and ribosomal gene activity in humans as evidenced by silver staining

1981 • 37 citations

Decreased synthesis of nucleolar RNA in aging human cells in vitro

1976 • 35 citations

Age-dependent variability of ribosomal RNA-gene activity in man as determined from frequencies of silver staining nucleolus organizing regions on metaphase chromosomes of lymphocytes and fibroblasts

1979 • 34 citations

Cellular changes with age

1952 • 30 citations

Some physiological aspects of aging in man.

1956 • 27 citations

Stimulation of ribosome synthesis during retarded ageing of human fibroblasts by hydrocortisone

1974 • 18 citations

Alterations with age in the informational storage and flow systems of the mammalian cell.

1978 • 12 citations

Cell-type specific codon usage and differentiation

1982 • 9 citations

Roles and mechanisms of rDNA changes during aging.

1978 • 8 citations

Polygamy and the evolution of human longevity

1979 • 4 citations

Age-related RNA polymerase I activity in isolated nuclei of PHA stimulated human lymphocytes

1986 • 4 citations