Superoxide radical-induced loss of nuclear restriction of immature mRNA: A possible cause for ageing

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

The Biology of Oxygen Radicals

1978 • 3,361 citations

Free Radicals in Biology

1976 • 1,879 citations

Nuclei from Rat Liver: Isolation Method That Combines Purity with High Yield

1966 • 1,687 citations

A Method for Isolation of Intact, Translationally Active Ribonucleic Acid

1983 • 1,469 citations

Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

1982 • 1,333 citations

The Free Radical Theory of Aging

2003 • 902 citations

Gene gating: a hypothesis.

1985 • 599 citations

Isolation and partial characterization of the Drosophila alcohol dehydrogenase gene.

1980 • 570 citations

Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species.

1980 • 385 citations

Organisation and sequences at the 5′ end of a cloned complete ovalbumin gene

1979 • 340 citations

Antioxidants, Aging, and Longevity

1984 • 279 citations

Heterogeneous nuclear RNA-protein fibers in chromatin-depleted nuclei.

1978 • 245 citations

Rat liver nuclear skeleton and ribonucleoprotein complexes containing HnRNA.

1978 • 243 citations

Ribonucleic acid precursors are associated with the chick oviduct nuclear matrix

1982 • 165 citations

Comparison of cytoplasmic superoxide dismutase in liver, heart and brain of aging rats and mice

1976 • 161 citations

Superoxide dismutase and superoxide radical in Morris hepatomas.

1980 • 135 citations

Evidence for involvement of nuclear envelope nucleoside triphosphatase in nucleocytoplasmic translocation of ribonucleoprotein

1976 • 132 citations

A preliminary study of the superoxide dismutase content of some human tumors.

1978 • 128 citations

Relationship between Metabolic Rate, Free Radicals, Differentiation and Aging: A Unified Theory

1985 • 127 citations

The Aging Brain: Cellular and Molecular Mechanisms of Aging in the Nervous System

1983 • 123 citations

The Nuclear Envelope and the Nuclear Matrix

1983 • 123 citations

The Free-Radical Theory of Aging

1982 • 115 citations

Superoxide dismutase and glutathione peroxidase activities in tumors

1977 • 110 citations

Age-dependent relaxation of gene repression: Increase of endogenous murine leukemia virus-related and globin-related RNA in brain and liver of mice

1978 • 96 citations

Transport of mRNA from Nucleus to Cytoplasm

1987 • 93 citations

Nuclear envelopes: Structure and biochemistry of the nuclear envelope

1974 • 80 citations

Altered regulation of the transport of RNA from nucleus to cytoplasm in rat hepatoma cells.

1972 • 77 citations

Changes with age in copper and superoxide dismutase levels in brains of C57BL/6J mice

1979 • 74 citations

Mature mRNA is selectively released from the nuclear matrix by an ATP/dATP-dependent mechanism sensitive to topoisomerase inhibitors.

1987 • 73 citations

Molecular classes of heterogeneous nuclear RNA in sea urchin embryos

1975 • 63 citations

Cytochalasin B selectively releases ovalbumin mRNA precursors but not the mature ovalbumin mRNA from hen oviduct nuclear matrix

1987 • 49 citations

A picomolar spectrophotometric assay for superoxide dismutase

1982 • 48 citations

Age-dependence of nuclear RNA processing

1977 • 44 citations

Evaluating the contribution of posttranscriptional processing to differential gene expression

1979 • 42 citations

Comparison of RNA synthesis by liver nuclei from rats of various ages

1978 • 38 citations

Modulation of poly(A)(+)mRNA-metabolizing and transporting systems under special consideration of microtubule protein and actin

1983 • 38 citations

Proteins from rat liver cytosol which stimulate mRNA transport

1986 • 37 citations

Avarol-induced DNA strand breakage in vitro and in Friend erythroleukemia cells.

1987 • 33 citations

Isolation and Purification of Rat Hepatoma Nuclei Active in the Transport of Messenger RNA in vitro

1982 • 24 citations

Alteration of Activity of Nuclear Envelope Nucleoside Triphosphatase in Quail Oviduct and Liver in Dependence on Physiological Factors

1983 • 22 citations

Age-dependence of polyadenylate stimulation of nuclear-envelope nucleoside triphosphatase

1982 • 22 citations

Age-Dependent Enzymatic Poly(A) Metabolism in Quail Oviduct

1979 • 21 citations

Transport of β‐globin mRNA from nuclei of murine friend erythroleukemia cells

1985 • 21 citations

Differential polyadenylation pattern of ovalbumin precursor RNAs during development

1986 • 21 citations

Differential changes of nuclear-envelope-associated enzyme activities involved in nucleocytoplasmic mRNA transport in the developing rat brain and liver

1986 • 18 citations

Occurrence of short-sized oligo(A) fragments during course of cell cycle and ageing

1983 • 17 citations

Evidence for age-dependent impairment of ovalbumin heterogeneous nuclear RNA (HnRNA) processing in hen oviduct

1985 • 13 citations

Altered RNA transport without derepression in a rat kidney tumor induced by dimethylnitrosamine

1979 • 13 citations

Nucleotide-specific Ribonucleases from Eukaryotes. Their Possible Roles During Poly(A) (+)mRNA Maturation and Degradation

1985 • 8 citations

Age-dependent changes of nuclear envelope protein phosphokinase and protein phosphatase activities. Significance for altered nucleo-cytoplasmic mRNA translocation during development

1984 • 5 citations