Expression of the receptor-linked protein tyrosine phosphatase LAR: proteolytic cleavage and shedding of the CAM-like extracellular region.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

The Immunoglobulin Superfamily—Domains for Cell Surface Recognition

1988 • 2,237 citations

Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis

1978 • 1,954 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

Electroporation for the efficient transfection of mammalian cells with DNA

1987 • 856 citations

Mammalian subtilisins: The long-sought dibasic processing endoproteases

1991 • 756 citations

The Leukocyte Common Antigen Family

1989 • 741 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

1991 • 589 citations

Exposed protein on the intact human erythrocyte

1971 • 494 citations

Shedding of tumor necrosis factor receptors by activated human neutrophils.

1990 • 443 citations

The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase.

1988 • 435 citations

Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.

1990 • 428 citations

A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases

1991 • 401 citations

Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification.

1989 • 395 citations

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

1990 • 378 citations

Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR.

1990 • 365 citations

Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens.

1987 • 327 citations

Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes.

1991 • 317 citations

cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family.

1989 • 313 citations

Protein-tyrosine phosphatases: The other side of the coin

1989 • 308 citations

Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues.

1991 • 306 citations

A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila.

1989 • 303 citations

Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.

1990 • 296 citations

A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen.

1988 • 277 citations

Deletion of genes on chromosome 1 in endocrine neoplasia

1987 • 265 citations

Selective Inactivation of the Exonuclease Activity of Bacteriophage T7 DNA Polymerase by in Vitro Mutagenesis

1989 • 258 citations

Insulin-Resistant Diabetes Due to a Point Mutation That Prevents Insulin Proreceptor Processing

1988 • 253 citations

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

1989 • 228 citations

Cloning of a cDNA for a major human protein-tyrosine-phosphatase.

1990 • 223 citations

Cloning and expression of a protein-tyrosine-phosphatase.

1990 • 215 citations

Structure of pre-pro-von Willebrand factor and its expression in heterologous cells

1986 • 212 citations

Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21.

1991 • 207 citations

Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin.

1991 • 203 citations

Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.

1991 • 198 citations

Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain.

1990 • 191 citations

Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum.

1991 • 190 citations

Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B.

1990 • 174 citations

Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control.

1988 • 164 citations

CD45, an integral membrane protein tyrosine phosphatase. Characterization of enzyme activity.

1990 • 163 citations

Structure of the chicken neuron-glia cell adhesion molecule, Ng-CAM: origin of the polypeptides and relation to the Ig superfamily.

1991 • 160 citations

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989 • 151 citations

Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain.

1990 • 149 citations

Characterization of CD45 and CD45R monoclonal antibodies using transfected mouse cell lines that express individual human leukocyte common antigens.

1988 • 140 citations

Distal deletion of chromosome Ip in ductal carcinoma of the breast.

1989 • 135 citations

Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells.

1991 • 102 citations

Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas.

1986 • 96 citations

Molecular characterization of protein tyrosine phosphatases.

1991 • 73 citations

Ligand and Protein Kinase C Downmodulate the Colony-Stimulating Factor 1 Receptor by Independent Mechanisms

1989 • 70 citations

Effects of amino acid replacements within the tetrabasic cleavage site on the processing of the human insulin receptor precursor expressed in Chinese hamster ovary cells.

1990 • 62 citations

Insulin resistance by unprocessed insulin proreceptors point mutation at the cleavage site

1988 • 46 citations

Rapid site-specific mutagenesis in plasmids

1987 • 44 citations

Insulin-mimetic effect of trypsin on the insulin receptor tyrosine kinase in intact adipocytes.

1987 • 34 citations

Characterization of an insulin receptor mutant lacking the subunit processing site.

1990 • 31 citations

Diagnosis, management, and pathogenetic studies in medullary thyroid carcinoma syndrome.

1989 • 16 citations

The preservation and loss of various non‐haematopoietic antigens in human post‐mortem tissues as demonstrated by monoclonal antibody immunohistological staining

1986 • 14 citations