Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes.

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

Insulin Biosynthesis: Evidence for a Precursor

1967 • 699 citations

Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus

1988 • 608 citations

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1990 • 579 citations

Proopiomelanocortin Processing in the Pituitary, Central Nervous System, and Peripheral Tissues

1988 • 535 citations

Cloning and Primary Sequence of a Mouse Candidate Prohormone Convertase PC1 Homologous to PC2, Furin, and Kex2: Distinct Chromosomal Localization and Messenger RNA Distribution in Brain and Pituitary Compared to PC2

1991 • 475 citations

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.

1991 • 449 citations

Glycosylation and processing of prepro-α-factor through the yeast secretory pathway

1984 • 410 citations

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases

1988 • 403 citations

Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.

1989 • 386 citations

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

1990 • 378 citations

Porcine Proinsulin: Characterization and Amino Acid Sequence

1968 • 318 citations

Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.

1990 • 296 citations

Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes

1990 • 259 citations

Insulin-Resistant Diabetes Due to a Point Mutation That Prevents Insulin Proreceptor Processing

1988 • 253 citations

Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein.

1986 • 207 citations

Cellular and molecular biology of neuropeptide processing and packaging

1989 • 203 citations

Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2

1990 • 202 citations

ISOLATION, PURIFICATION, AND CHARACTERIZATION OF γ-LIPOTROPIC HORMONE FROM SHEEP PITUITARY GLANDS

1967 • 191 citations

Yeast KEX2 Endopeptidase Correctly Cleaves a Neuroendocrine Prohormone in Mammalian Cells

1988 • 173 citations

Evidence for pro-β-nerve growth factor, a biosynthetic precursor to β-nerve growth factor

1977 • 153 citations

Expression of Mouse Proopiomelanocortin in an Insulinoma Cell Line

1989 • 38 citations

[20] Use of vaccinia virus as a neuropeptide expression vector

1986 • 31 citations

An in vivo characterization of the cleavage site specificity of the insulin cell prohormone processing enzymes.

1990 • 27 citations