Characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain Reaction

1986 • 3,400 citations

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

1989 • 3,180 citations

SV40-transformed simian cells support the replication of early SV40 mutants

1981 • 2,564 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II

1983 • 779 citations

Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40

1987 • 762 citations

Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells

1990 • 706 citations

Absence of HeLa Cell Contamination in 169 Cell Lines Derived From Human Tumors2

1977 • 648 citations

Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer

1990 • 576 citations

Generation of cAMP-Activated Chloride Currents by Expression of CFTR

1991 • 550 citations

Genomic DNA sequence of the cystic fibrosis transmembrane conductance regulator (CFTR) gene

1991 • 550 citations

Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

1991 • 508 citations

Identification of mutations in regions corresponding to the two putative nucleotide (ATP)-binding folds of the cystic fibrosis gene.

1990 • 433 citations

A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein

1990 • 397 citations

The human β-interferon gene enhancer is under negative control

1986 • 395 citations

Host-range mutants of adenovirus type 5 defective for growth in HeLa cells

1977 • 330 citations

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.

1988 • 271 citations

Transcriptional "silencer" element in rat repetitive sequences associated with the rat insulin 1 gene locus.

1986 • 257 citations

Activity of two different silencer elements of the chicken lysozyme gene can be compensated by enhancer elements.

1987 • 226 citations

Hormonal control of human colon carcinoma cell growth in serum-free medium.

1980 • 219 citations

αβ lineage-specific expression of the α T cell receptor gene by nearby silencers

1989 • 182 citations

The cystic fibrosis gene has a “housekeeping”-type promoter and is expressed at low levels in cells of epithelial origin

1991 • 170 citations

Identification of a transcriptional silencer in the 5'-flanking region of the human epsilon-globin gene.

1989 • 158 citations

Two silencers regulate the tissue-specific expression of the collagen II gene.

1990 • 128 citations

Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity

1986 • 123 citations

DNA marker haplotype association with pancreatic sufficiency in cystic fibrosis.

1989 • 105 citations

cAMP-inducible chloride conductance in mouse fibroblast lines stably expressing the human cystic fibrosis transmembrane conductance regulator.

1991 • 102 citations

Repression mediates cell-type-specific expression of the rat growth hormone gene.

1986 • 99 citations

Down-regulation of cystic fibrosis gene mRNA transcript levels and induction of the cystic fibrosis chloride secretory phenotype in epithelial cells by phorbol ester

1991 • 94 citations

Multiple regulatory elements of the murine γ2-crystallin promoter

1989 • 66 citations

Transformed sweat gland and nasal epithelial cell lines from control and cystic fibrosis individuals

1990 • 30 citations