Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

2015 • 15,801 citations

mTOR Signaling in Growth Control and Disease

2012 • 7,638 citations

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

mTOR: from growth signal integration to cancer, diabetes and ageing

2010 • 3,777 citations

Cell cycle, CDKs and cancer: a changing paradigm

2009 • 3,486 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

2008 • 2,551 citations

The functions and regulation of the PTEN tumour suppressor

2012 • 1,792 citations

The RB and p53 pathways in cancer

2002 • 1,612 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

Regulation of TORC1 by Rag GTPases in nutrient response

2008 • 1,260 citations

PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase

2007 • 1,176 citations

Sibling rivalry in the E2F family

2002 • 1,158 citations

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

2007 • 1,132 citations

Cellular mechanisms of tumour suppression by the retinoblastoma gene

2008 • 902 citations

The retinoblastoma tumour suppressor in development and cancer

2002 • 736 citations

Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

1996 • 700 citations

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1995 • 681 citations

Cyclin E Ablation in the Mouse

2003 • 640 citations

Mouse Development and Cell Proliferation in the Absence of D-Cyclins

2004 • 630 citations

Molecular mechanisms underlying RB protein function

2013 • 507 citations

Conserved functions of the pRB and E2F families

2008 • 477 citations

mTOR in aging, metabolism, and cancer

2013 • 429 citations

CDK 4/6 Inhibitors Sensitize PIK3CA Mutant Breast Cancer to PI3K Inhibitors

2014 • 405 citations

Requirement for cyclin D3 in lymphocyte development and T cell leukemias

2003 • 336 citations

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

2015 • 329 citations

Tailoring to RB: tumour suppressor status and therapeutic response

2008 • 328 citations

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

2014 • 323 citations

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment

1991 • 319 citations

The Requirement for Cyclin D Function in Tumor Maintenance

2012 • 311 citations

Altered Cell Cycle Kinetics, Gene Expression, and G₁ Restriction Point Regulation in Rb-Deficient Fibroblasts

1996 • 301 citations

Structure of the Rb C-Terminal Domain Bound to E2F1-DP1: A Mechanism for Phosphorylation-Induced E2F Release

2005 • 242 citations

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

2013 • 229 citations

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

2011 • 175 citations

Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit

2006 • 174 citations

mTOR signaling in tumorigenesis

2014 • 157 citations

Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.

1994 • 148 citations

Modification of the DNA Damage Response by Therapeutic CDK4/6 Inhibition

2012 • 142 citations

The retinoblastoma protein induces apoptosis directly at the mitochondria

2013 • 120 citations

Retinoblastoma tumor suppressor pathway in breast cancer: prognosis, precision medicine, and therapeutic interventions

2014 • 115 citations

S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation

1997 • 107 citations

Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

2015 • 82 citations

Targeting Breast Cancer with CDK Inhibitors

2015 • 74 citations

Nucleocytoplasmic Shuttling of the Retinoblastoma Tumor Suppressor Protein via Cdk Phosphorylation-dependent Nuclear Export

2006 • 60 citations

mSIN1 Protein Mediates SGK1 Protein Interaction with mTORC2 Protein Complex and Is Required for Selective Activation of the Epithelial Sodium Channel

2011 • 57 citations

Rb/E2F: A two-edged sword in the melanocytic system

2005 • 53 citations

Aberrant nucleocytoplasmic localization of the retinoblastoma tumor suppressor protein in human cancer correlates with moderate/poor tumor differentiation

2007 • 50 citations

Multiple Mechanisms for E2F Binding Inhibition by Phosphorylation of the Retinoblastoma Protein C-Terminal Domain

2013 • 42 citations

Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function

2000 • 39 citations

Expression of Cell Cycle–Regulated Proteins pRB2/p130, p107, E2F4, p27, and pCNA in Salivary Gland Tumors: Prognostic and Diagnostic Implications

2005 • 33 citations

Reverse Mutational Analysis Reveals Threonine-373 as a Potentially Sufficient Phosphorylation Site for Inactivation of the Retinoblastoma Tumor Suppressor Protein (pRB)

2006 • 24 citations

Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization

2013 • 15 citations

Cell Cycle Inhibitors Make Progress

2014 • 12 citations

Nutrient sensing lost in cancer

2013 • 10 citations