Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

Hallmarks of Cancer: The Next Generation

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Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

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mTOR Signaling in Growth Control and Disease

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Integrated genomic analyses of ovarian carcinoma

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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

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TOR Signaling in Growth and Metabolism

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Cellular senescence: when bad things happen to good cells

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mTOR: from growth signal integration to cancer, diabetes and ageing

2010 • 3,777 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

Defining the Role of mTOR in Cancer

2007 • 2,755 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 • 2,574 citations

Molecular mechanisms of mTOR-mediated translational control

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

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Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

2006 • 1,365 citations

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

2006 • 1,358 citations

mTOR and cancer: insights into a complex relationship

2006 • 1,299 citations

PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase

2007 • 1,176 citations

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

2007 • 1,132 citations

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

2004 • 1,101 citations

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

2011 • 1,040 citations

FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis

2007 • 1,018 citations

Akt, FoxO and regulation of apoptosis

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Dysregulation of the TSC-mTOR pathway in human disease

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GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

2003 • 927 citations

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

2008 • 876 citations

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

2011 • 818 citations

Amino acid signalling upstream of mTOR

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Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

2004 • 773 citations

Encoding and Decoding Cellular Information through Signaling Dynamics

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p53 Dynamics Control Cell Fate

2012 • 729 citations

mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

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Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

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COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer

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An expanding role for mTOR in cancer

2005 • 519 citations

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

2006 • 497 citations

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

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Transcriptional control of preadipocyte determination by Zfp423

2010 • 475 citations

mTOR signaling in disease

2011 • 437 citations

Amino acids and mTORC1: from lysosomes to disease

2012 • 423 citations

Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1

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Peptide and Protein Library Screening Defines Optimal Substrate Motifs for AKT/PKB

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Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

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Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

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PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR

2007 • 353 citations

Triple Layer Control: Phosphorylation, Acetylation and Ubiquitination of FOXO Proteins

2005 • 289 citations

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

2010 • 251 citations

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

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Rapid and sustained nuclear–cytoplasmic ERK oscillations induced by epidermal growth factor

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Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

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mTORC1 Phosphorylates the ULK1-mAtg13-FIP200 Autophagy Regulatory Complex

2009 • 203 citations

mTOR-Dependent Cell Survival Mechanisms

2012 • 183 citations

Transformation of Human and Murine Fibroblasts without Viral Oncoproteins

2005 • 173 citations

The Actin-Bundling Protein Palladin Is an Akt1-Specific Substrate that Regulates Breast Cancer Cell Migration

2010 • 172 citations

Rictor is a novel target of p70 S6 kinase-1

2009 • 153 citations

Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase

2012 • 142 citations

FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis

2010 • 138 citations

mTOR signaling for biological control and cancer

2013 • 135 citations

A Two-Dimensional ERK-AKT Signaling Code for an NGF-Triggered Cell-Fate Decision

2011 • 127 citations

Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction

2010 • 90 citations

Characterization of Phosphatidylinositol 3-Kinase-dependent Phosphorylation of the Hydrophobic Motif Site Thr389 in p70 S6 Kinase 1

2002 • 79 citations

TSC1 Sets the Rate of Ribosome Export and Protein Synthesis through Nucleophosmin Translation

2007 • 41 citations

Activation of a GST-tagged AKT2/PKBβ

2005 • 6 citations

Signal transduction and signaling networks

2013 • 2 citations