Expression of Cell Cycle–Regulated Proteins pRB2/p130, p107, E2F4, p27, and pCNA in Salivary Gland Tumors: Prognostic and Diagnostic Implications

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

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1958 • 37,219 citations

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1979 • 1,941 citations

Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ

1987 • 1,766 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Salivary neoplasms: Overview of a 35‐year experience with 2,807 patients

1986 • 1,405 citations

Tumors of the major salivary glands

1953 • 1,089 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

1992 • 381 citations

Cell cycle-specific association of E2F with the p130 E1A-binding protein.

1993 • 348 citations

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

1994 • 331 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

Medical Uses of Statistics.

1989 • 305 citations

Immunohistochemical detection of proliferating cell nuclear antigen in solid human malignancies.

1987 • 304 citations

E2F-5, a New E2F Family Member That Interacts with p130 In Vivo

1995 • 232 citations

p130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107.

1994 • 211 citations

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.

1996 • 207 citations

The subcellular localization of E2F-4 is cell-cycle dependent

1997 • 193 citations

Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members

1996 • 151 citations

Epithelial Tumours of the Salivary Glands.

1971 • 142 citations

Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma

1997 • 129 citations

Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer.

2000 • 102 citations

Cell Cycle Analysis of E2F in Primary Human T Cells Reveals Novel E2F Complexes and Biochemically Distinct Forms of Free E2F

1993 • 94 citations

Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer.

1997 • 93 citations

Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth.

1998 • 87 citations

Expression of the retinoblastoma-related gene Rb2/p130 correlates with clinical outcome in endometrial cancer.

1998 • 85 citations

The RB family of cell cycle regulatory factors

1998 • 81 citations

Genetic Alterations of the Retinoblastoma-Related Gene RB2/p130 Identify Different Pathogenetic Mechanisms in and among Burkitt's Lymphoma Subtypes

2000 • 79 citations

The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19.

1993 • 77 citations

Genetic alterations disrupting the nuclear localization of the retinoblastoma-related gene RB2/p130 in human tumor cell lines and primary tumors.

2000 • 76 citations

Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma.

2000 • 74 citations

Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma.

2002 • 72 citations

Retinoblastoma-Related Protein pRb2/p130 and Suppression of Tumor Growth In Vivo

1998 • 71 citations

Differential expression of the retinoblastoma gene family members pRb/p105, p107, and pRb2/p130 in lung cancer.

1996 • 64 citations

c‐myc, ras p21 and p53 Expression in pleomorphic adenoma and its malignant form of the human salivary glands

1993 • 58 citations

Immunohistochemical expression of retinoblastoma pathway proteins in normal salivary glands and in salivary gland tumours

2003 • 48 citations

Mutations associated with carcinomas arising from pleomorphic adenomas of the salivary glands

1996 • 48 citations

Immunoreactivity of proliferating cell nuclear antigen in salivary gland tumours: An assessment of growth potential

1993 • 48 citations

pRb2/p130, Vascular Endothelial Growth Factor, p27(KIP1), and Proliferating Cell Nuclear Antigen Expression in Hepatocellular Carcinoma

2004 • 46 citations

Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.

1994 • 45 citations

Regulation of E2F4 mitogenic activity during terminal differentiation by its heterodimerization partners for nuclear translocation.

1998 • 44 citations

Differential expression of the retinoblastoma gene family members in choroidal melanoma: prognostic significance.

1999 • 41 citations

Retinoblastoma-related p107 and pRb2/p130 proteins in malignant lymphomas: distinct mechanisms of cell growth control.

1999 • 41 citations

Proliferative activity of salivary gland pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (LI)

1993 • 35 citations

pRb2/p130 Protein expression is correlated with clinicopathologic findings in patients with oral squamous cell carcinoma

2001 • 31 citations

High Correlation with Survival of Proliferating Cell Nuclear Antigen Expression in Mucoepidermoid Carcinoma of the Parotid Gland

1994 • 28 citations

Characterization of an E2F-p130 complex formed during growth arrest

1997 • 27 citations

Immunohistochemical investigation of new suppressor oncogene p130 in oral squamous cell carcinoma

1999 • 22 citations

Oral squamous cell carcinoma: electron microscopic and immunohistochemical characteristics

2002 • 20 citations

Polymorphous low-grade adenocarcinoma

1997 • 19 citations

Polymorphous low grade adenocarcinoma: Flow cytometric, P53 and PCNA analysis

1995 • 19 citations

Genetic Alterations in the Retinoblastoma Protein-Related p107 Gene in Human Hematologic Malignancies

1998 • 15 citations

Contingency Tables in Medical Studies

2019 • 6 citations