mTOR in aging, metabolism, and cancer

mTOR Signaling in Growth Control and Disease

2012 • 7,638 citations

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis

2007 • 5,258 citations

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

2006 • 3,685 citations

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

2009 • 3,397 citations

Loss of autophagy in the central nervous system causes neurodegeneration in mice

2006 • 3,331 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 • 2,561 citations

The genetics of ageing

2010 • 2,550 citations

Metformin and reduced risk of cancer in diabetic patients

2005 • 2,278 citations

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

2009 • 2,152 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

2010 • 1,785 citations

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

2009 • 1,718 citations

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

2010 • 1,614 citations

A unifying model for mTORC1-mediated regulation of mRNA translation

2012 • 1,364 citations

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

2006 • 1,358 citations

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

2003 • 1,328 citations

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

2005 • 1,272 citations

The translational landscape of mTOR signalling steers cancer initiation and metastasis

2012 • 1,237 citations

Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway

2004 • 1,229 citations

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

2008 • 1,222 citations

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

2008 • 1,221 citations

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

2000 • 1,213 citations

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

1998 • 1,173 citations

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

1999 • 1,151 citations

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

2012 • 1,089 citations

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

2011 • 1,082 citations

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

2012 • 1,070 citations

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

2009 • 1,068 citations

FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis

2007 • 1,018 citations

Influence of TOR kinase on lifespan in C. elegans

2003 • 1,017 citations

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

2010 • 974 citations

Extension of chronological life span in yeast by decreased TOR pathway signaling

2006 • 939 citations

Rapamycin passes the torch: a new generation of mTOR inhibitors

2011 • 914 citations

Selective versus Total Insulin Resistance: A Pathogenic Paradox

2008 • 888 citations

Regulation of Longevity and Stress Resistance by Sch9 in Yeast

2001 • 858 citations

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

2006 • 856 citations

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

2010 • 849 citations

IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a

2004 • 845 citations

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

2011 • 841 citations

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

2010 • 806 citations

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

1999 • 771 citations

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

1999 • 727 citations

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

2010 • 687 citations

The TOR pathway interacts with the insulin signaling pathway to regulateC. eleganslarval development, metabolism and life span

2004 • 682 citations

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

2010 • 674 citations

Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

1999 • 668 citations

Glutaminolysis Activates Rag-mTORC1 Signaling

2012 • 636 citations

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

2004 • 634 citations

Rapamycin slows aging in mice

2012 • 628 citations

Activation of mTORC2 by Association with the Ribosome

2011 • 625 citations

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

2009 • 619 citations

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

2008 • 614 citations

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

2010 • 597 citations

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

2012 • 588 citations

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

2011 • 578 citations

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

2011 • 561 citations

The Pharmacology of mTOR Inhibition

2009 • 560 citations

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

2010 • 544 citations

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

2009 • 523 citations

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

2012 • 501 citations

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans

2006 • 491 citations

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

2010 • 477 citations

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

2008 • 468 citations

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

2008 • 460 citations

Tumours with PI3K activation are resistant to dietary restriction

2009 • 448 citations

mTOR signaling in disease

2011 • 437 citations

Regulation of Peroxisome Proliferator–Activated Receptor-γ Activity by Mammalian Target of Rapamycin and Amino Acids in Adipogenesis

2004 • 431 citations

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

2008 • 431 citations

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

2010 • 416 citations

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

2009 • 409 citations

Sirolimus Is Associated with New-Onset Diabetes in Kidney Transplant Recipients

2008 • 405 citations

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

2008 • 399 citations

Obesity and hepatocellular carcinoma

2004 • 393 citations

mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

2009 • 379 citations

Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway

2009 • 377 citations

Metformin: Taking away the candy for cancer?

2010 • 376 citations

Atrophy of S6K1−/− skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control

2005 • 369 citations

mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

2008 • 364 citations

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

2009 • 345 citations

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

2010 • 336 citations

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

2007 • 316 citations

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

2010 • 314 citations

Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis

2009 • 312 citations

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

2010 • 311 citations

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

2011 • 295 citations

Bcl-2 Inhibition of Autophagy: A New Route to Cancer?

2006 • 290 citations

TOR complex 2: a signaling pathway of its own

2009 • 271 citations

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

2009 • 254 citations

Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice

2010 • 245 citations

Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

2010 • 244 citations

Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy

2012 • 227 citations

Metabolic transformation in cancer

2009 • 227 citations

Cardiac Raptor Ablation Impairs Adaptive Hypertrophy, Alters Metabolic Gene Expression, and Causes Heart Failure in Mice

2011 • 224 citations

Amino Acid Signaling in TOR Activation

2011 • 221 citations

Muscle-Specific Deletion of Rictor Impairs Insulin-Stimulated Glucose Transport and Enhances Basal Glycogen Synthase Activity

2007 • 207 citations

Distinct perturbation of the translatome by the antidiabetic drug metformin

2012 • 192 citations

Lifelong rapamycin administration ameliorates age‐dependent cognitive deficits by reducing IL‐1β and enhancing NMDA signaling

2011 • 189 citations

S6K1 Plays a Critical Role in Early Adipocyte Differentiation

2010 • 186 citations

S6 Kinase Deletion Suppresses Muscle Growth Adaptations to Nutrient Availability by Activating AMP Kinase

2007 • 178 citations

The search for DAF-16/FOXO transcriptional targets: Approaches and discoveries

2006 • 178 citations

mTOR links oncogenic signaling to tumor cell metabolism

2011 • 175 citations

mTOR complex 2 in adipose tissue negatively controls whole-body growth

2009 • 175 citations

Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity

2006 • 172 citations

Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice

2012 • 171 citations

RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

2010 • 165 citations

The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging

2008 • 162 citations

daf-16 Protects the Nematode Caenorhabditis elegans During Food Deprivation

2006 • 159 citations

Subfield History: Caloric Restriction, Slowing Aging, and Extending Life

2003 • 146 citations

Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2

2012 • 146 citations

Regulation of adipocyte differentiation and insulin action with rapamycin

2004 • 139 citations

Life Span Extension via eIF4G Inhibition Is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans

2011 • 136 citations

A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation

2011 • 127 citations

Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase

2010 • 122 citations

Rapamycin Inhibits Human Adipocyte Differentiation in Primary Culture

2000 • 109 citations

Co-expression of glutaminase K and L isoenzymes in human tumour cells

2005 • 100 citations

Rapamycin‐sensitive phase of 3T3‐L1 preadipocyte differentiation after clonal expansion

2001 • 80 citations

Tuberous Sclerosis Complex-1 Deficiency Attenuates Diet-Induced Hepatic Lipid Accumulation

2011 • 66 citations

Inhibition of insulin signaling and adipogenesis by rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1

2004 • 58 citations

Protein Synthesis Is a Novel Determinant of Aging in Caenorhabditis elegans

2007 • 58 citations

TORC2 Signaling Is Antagonized by Protein Phosphatase 2A and the Far Complex in Saccharomyces cerevisiae

2012 • 41 citations

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

2011 • 40 citations

LST8 Regulates Cell Growth via Target-of-Rapamycin Complex 2 (TORC2)

2012 • 34 citations

TOR Signaling and Aging

2010 • 8 citations