Multiple Mechanisms for E2F Binding Inhibition by Phosphorylation of the Retinoblastoma Protein C-Terminal Domain

NMRPipe: A multidimensional spectral processing system based on UNIX pipes

1995 • 15,623 citations

NMR View: A computer program for the visualization and analysis of NMR data

1994 • 3,061 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Sibling rivalry in the E2F family

2002 • 1,158 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Cdk Phosphorylation Triggers Sequential Intramolecular Interactions that Progressively Block Rb Functions as Cells Move through G1

1999 • 1,028 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Cellular mechanisms of tumour suppression by the retinoblastoma gene

2008 • 902 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

Improved Sensitivity of HSQC Spectra of Exchanging Protons at Short Interscan Delays Using a New Fast HSQC (FHSQC) Detection Scheme That Avoids Water Saturation

1995 • 621 citations

Molecular mechanisms underlying RB protein function

2013 • 507 citations

Differential Phosphorylation of the Retinoblastoma Protein by G1/S Cyclin-dependent Kinases

1997 • 486 citations

Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product

1989 • 457 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

Identification of a growth suppression domain within the retinoblastoma gene product.

1992 • 413 citations

Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.

1997 • 396 citations

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

1991 • 343 citations

Differential Regulation of Retinoblastoma Protein Function by Specific Cdk Phosphorylation Sites

1996 • 306 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

Cyclin C/Cdk3 Promotes Rb-Dependent G0 Exit

2004 • 300 citations

Dual Mechanisms for the Inhibition of E2F Binding to RB by Cyclin-Dependent Kinase-Mediated RB Phosphorylation

1997 • 293 citations

Comparison of techniques for 1H-detected heteronuclear 1H15N Spectroscopy

1990 • 251 citations

Structure of the Rb C-Terminal Domain Bound to E2F1-DP1: A Mechanism for Phosphorylation-Induced E2F Release

2005 • 242 citations

Deciphering the retinoblastoma protein phosphorylation code

2012 • 237 citations

Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function

2002 • 196 citations

Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.

1994 • 148 citations

Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor

2002 • 147 citations

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation

2003 • 142 citations

Phosphorylation-induced Conformational Changes in the Retinoblastoma Protein Inhibit E2F Transactivation Domain Binding

2010 • 135 citations

Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control

2012 • 131 citations

The retinoblastoma protein binds E2F residues required for activation in vivo and TBP bindingin vitro

1993 • 131 citations

pRB Contains an E2F1-Specific Binding Domain that Allows E2F1-Induced Apoptosis to Be Regulated Separately from Other E2F Activities

2003 • 126 citations

Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases

1999 • 121 citations

Cumulative Effect of Phosphorylation of pRB on Regulation of E2F Activity

1999 • 114 citations

Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription Factor

2003 • 106 citations

Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression.

1992 • 60 citations

Defining the substrate specificity of cdk4 kinasecyclin D1 complex

1999 • 47 citations

The biochemical basis of CDK phosphorylation-independent regulation of E2F1 by the retinoblastoma protein

2011 • 46 citations

Mitogen-induced Rapid Phosphorylation of Serine 795 of the Retinoblastoma Gene Product in Vascular Smooth Muscle Cells Involves ERK Activation

2004 • 37 citations

Structural Insights into the Mechanism of Phosphoregulation of the Retinoblastoma Protein

2013 • 18 citations

The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F

2008 • 12 citations