Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Hallmarks of Cancer: The Next Generation

2011 • 58,651 citations

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

AKT/PKB Signaling: Navigating Downstream

2007 • 5,728 citations

mTOR: from growth signal integration to cancer, diabetes and ageing

2010 • 3,777 citations

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

2008 • 2,099 citations

Perturbations of the AKT signaling pathway in human cancer

2005 • 1,300 citations

Targeting the PI3K-Akt pathway in human cancer

2003 • 1,262 citations

Mammalian cyclin-dependent kinases

2005 • 1,201 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Geminin, an Inhibitor of DNA Replication, Is Degraded during Mitosis

1998 • 886 citations

PHLPP: A Phosphatase that Directly Dephosphorylates Akt, Promotes Apoptosis, and Suppresses Tumor Growth

2005 • 872 citations

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2

2003 • 808 citations

MATHEMATICAL ANALYSIS OF DNA DISTRIBUTIONS DERIVED FROM FLOW MICROFLUOROMETRY

1974 • 795 citations

Second-generation shRNA libraries covering the mouse and human genomes

2005 • 616 citations

Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP

2002 • 492 citations

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

2004 • 485 citations

Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation

2002 • 416 citations

Anaphase-Promoting Complex/Cyclosome–Dependent Proteolysis of Human Cyclin a Starts at the Beginning of Mitosis and Is Not Subject to the Spindle Assembly Checkpoint

2001 • 413 citations

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

2008 • 387 citations

Identification of a Cyclin-cdk2 Recognition Motif Present in Substrates and p21-Like Cyclin-Dependent Kinase Inhibitors

1996 • 368 citations

Quantitative Live Cell Imaging Reveals a Gradual Shift between DNA Repair Mechanisms and a Maximal Use of HR in Mid S Phase

2012 • 345 citations

Delayed early embryonic lethality following disruption of the murine cyclin A2 gene

1997 • 271 citations

Carboxyl-Terminal Modulator Protein (CTMP), a Negative Regulator of PKB/Akt and v-Akt at the Plasma Membrane

2001 • 254 citations

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

2009 • 241 citations

IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation

2011 • 217 citations

Cyclin A Is Redundant in Fibroblasts but Essential in Hematopoietic and Embryonic Stem Cells

2009 • 203 citations

Acetylation-Dependent Regulation of Skp2 Function

2012 • 198 citations

Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase

2010 • 191 citations

Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis

2008 • 182 citations

New Insights into mTOR Signaling: mTORC2 and Beyond

2009 • 181 citations

Spatiotemporal Analysis of Differential Akt Regulation in Plasma Membrane Microdomains

2008 • 149 citations

A Fluorescent Reporter of AMPK Activity and Cellular Energy Stress

2011 • 142 citations

Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase

2012 • 142 citations

Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases

2007 • 138 citations

PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS

2012 • 124 citations

Distinct mechanisms act in concert to mediate cell cycle arrest

2009 • 118 citations

Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction

2010 • 90 citations

Abolition of Cyclin-Dependent Kinase Inhibitor p16^Ink4a and p21^Cip1/Waf1 Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human Fibroblasts

2003 • 71 citations

Cdh1 Regulates Cell Cycle through Modulating the Claspin/Chk1 and the Rb/E2F1 Pathways

2009 • 68 citations

Genetic Organization, Length Conservation, and Evolution of RNA Polymerase II Carboxyl-Terminal Domain

2010 • 61 citations

Cell Cycle Machinery:

2008 • 59 citations

Cerebellar cortical lamination and foliation require cyclin A2

2013 • 19 citations

Akt signaling: a damaging interaction makes good

2008 • 16 citations

Getting in the Ring: Proline-Directed Substrate Specificity in the Cell Cycle Proteins Cdc14 and CDK2-CyclinA3

2003 • 14 citations

Double or quit?

2011 • 7 citations