Interleukin-5 and Its Receptor System: Implications in the Immune System and Inflammation

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Eosinophilic Inflammation in Asthma

1990 • 2,535 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

1989 • 1,199 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

1993 • 988 citations

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

1988 • 976 citations

Identification of Activated T Lymphocytes and Eosinophils in Bronchial Biopsies in Stable Atopic Asthma

1990 • 890 citations

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

1992 • 889 citations

Interleukin-5, eosinophils, and disease

1992 • 874 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.

1991 • 841 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

The Eosinophilic Leukocyte: Structure and Function

1986 • 828 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Interleukin-5, eosinophils, and disease

1992 • 771 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

1992 • 693 citations

Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.

1991 • 676 citations

YERSINIA ENTEROCOLITICA INFECTIONS AND PORK: THE MISSING LINK

1987 • 654 citations

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

1990 • 650 citations

Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice

1989 • 635 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

1991 • 617 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

B-Cell Stimulatory Factor-1/Interleukin 4

1987 • 602 citations

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1991 • 598 citations

Eosinophilia in transgenic mice expressing interleukin 5.

1990 • 579 citations

Molecular Regulation of B Lymphocyte Response

1988 • 579 citations

Asthma and inflammation.

2012 • 569 citations

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

1989 • 567 citations

A novel family of growth factor receptors: A common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor β-chain

1989 • 551 citations

An Eosinophil-Dependent Mechanism for the Antitumor Effect of Interleukin-4

1992 • 540 citations

Replacement of T-Cell Function by a T-Cell Product

1972 • 537 citations

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.

1990 • 487 citations

Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

1986 • 480 citations

Regulation of B-Cell Growth and Differentiation by Soluble Factors

1983 • 432 citations

The alphas, betas, and kinases of cytokine receptor complexes

1993 • 418 citations

Cloning of an Interleukin-3 Receptor Gene: a Member of a Distinct Receptor Gene Family

1990 • 417 citations

Identification of T lymphocytes, Macrophages, and Activated Eosinophils in the Bronchial Mucosa in Intrinsic Asthma: Relationship to Symptoms and Bronchial Responsiveness

1992 • 414 citations

Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II

1986 • 405 citations

T cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma.

1991 • 395 citations

Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production.

1989 • 394 citations

Strategies of Anti‐Cytokine Monoclonal Antibody Development: Immunoassay of IL‐10 and IL‐5 in Clinical Samples

1992 • 384 citations

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation.

1992 • 365 citations

Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics.

1992 • 364 citations

T LYMPHOCYTE ACTIVATION IN ACUTE SEVERE ASTHMA

1988 • 353 citations

CD4⁺T-Lymphocytes and Interleukin-5 Mediate Antigen-induced Eosinophil Infiltration into the Mouse Trachea

1992 • 353 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

Regulatory effect of cytokines on eosinophil degranulation.

1990 • 337 citations

IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner.

1990 • 328 citations

CD4 T-Lymphocyte Activation in Acute Severe Asthma: Relationship to Disease Severity and Atopic Status

1990 • 327 citations

Selective differentiation and proliferation of hematopoietic cells induced by recombinant human interleukins.

1988 • 327 citations

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

1993 • 311 citations

Peritoneal Ly‐1 B cells: Genetic control, autoantibody production, increased lambda light chain expression

1986 • 306 citations

Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.

1991 • 303 citations

Normal, Autoimmune, and Malignant CD5+ B Cells: The LY-1 B Lineage?

1988 • 302 citations

Signal transduction of the human granulocyte-macrophage colony- stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins

1990 • 294 citations

Identification of T-lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma

1992 • 279 citations

Subunit promiscuity among hemopoietic growth factor receptors

1991 • 273 citations

Cytokine receptors and signal transduction

1992 • 269 citations

Development and Physiology of LY‐1 B and its Human Homolog, LEU‐1 B

1986 • 269 citations

CD4 T-Lymphocyte Activation in Asthma Is Accompanied by Increased Serum Concentrations of Interleukin-5: Effect of Glucocorticoid Therapy

1993 • 264 citations

The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent.

1988 • 261 citations

Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression.

1987 • 259 citations

Tumour-associated eosinophilia: a review.

1981 • 255 citations

A novel dimer configuration revealed by the crystal structure at 2.4 Å resolution of human interleukin-5

1993 • 247 citations

Effect of Anti-IL-5 and IL-5 on Airway Hyperreactivity and Eosinophils in Guinea Pigs

1993 • 245 citations

Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease.

1992 • 244 citations

Circular DNA is excised by immunoglobulin class switch recombination

1990 • 244 citations

T Cell‐Replacing Factor (TRF)/Interleukin 5 (IL‐5): Molecular and Functional Properties

1988 • 241 citations

Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching

1990 • 240 citations

The role of IL-5 in IgA B cell differentiation.

1988 • 240 citations

Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni.

1990 • 238 citations

The Human Gene Encoding GM-CSF Is at 5q21-q32, the Chromosome Region Deleted in the 5q ^- Anomaly

1985 • 237 citations

Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome.

1989 • 234 citations

Evidence for the Involvement of GM-CSF and FMS in the Deletion (5q) in Myeloid Disorders

1986 • 233 citations

Molecular cloning and expression of the murine interleukin-5 receptor.

1990 • 227 citations

Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects

1992 • 226 citations

Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor.

1991 • 221 citations

Detection of interleukin-5 messenger RNA in Reed-Sternberg cells of Hodgkin's disease with eosinophilia

1990 • 220 citations

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein.

1992 • 213 citations

Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3).

1992 • 206 citations

Cloning of cDNA for human T-cell replacing factor (interieukin-5) and comparison with the murine homologue

1986 • 205 citations

Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays.

1983 • 204 citations

Molecular cloning and expression of the human interleukin 5 receptor.

1992 • 199 citations

The development and repertoire of B-1 cells (CD5 B cells)

1991 • 198 citations

A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization.

1987 • 196 citations

Eosinophil infiltration of human colonic carcinomas as a prognostic indicator.

1983 • 193 citations

Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family.

1990 • 192 citations

Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects

1992 • 181 citations

Recombinant human interleukin 5 is an eosinophil differentiation factor but has no activity in standard human B cell growth factor assays

1987 • 180 citations

Hemopoietic lineage switch: v-raf oncogene converts Eμmyc transgenic B cells into macrophages

1988 • 179 citations

c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3.

1993 • 170 citations

Antigen-induced T cell-replacing factor (TRF). III. Establishment of T cell hybrid clone continuously producing TRF and functional analysis of released TRF.

1980 • 166 citations

Transforming growth factor beta 1 selectivity stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cells.

1993 • 162 citations

Transforming growth factor beta 1 increases IgA isotype switching at the clonal level.

1990 • 150 citations

Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage.

1989 • 149 citations

Depletion of eosinophils by anti-IL-5 monoclonal antibody treatment of mice infected with Trichinella spiralis does not alter parasite burden or immunologic resistance to reinfection.

1992 • 147 citations

Identification of the second subunit of the murine interleukin-5 receptor: interleukin-3 receptor-like protein, AIC2B is a component of the high affinity interleukin-5 receptor.

1991 • 144 citations

GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells

1992 • 142 citations

Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes.

1987 • 140 citations

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.

1992 • 140 citations

Molecular characterization of germ-line immunoglobulin A transcripts produced during transforming growth factor type beta-induced isotype switching.

1990 • 138 citations

Formation of B Lymphocytes in Fetal and Adult Life

1981 • 135 citations

Interleukin-5 Modulates Eosinophil Accumulation in Allergic Guinea Pig Lung

1992 • 135 citations

Reciprocal inhibition of binding between interleukin 3 and granulocyte-macrophage colony-stimulating factor to human eosinophils.

1989 • 133 citations

Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients.

1990 • 131 citations

Malignant tumor and eosinophils: I. Prognostic significance in gastric cancer

1986 • 128 citations

Release of granule proteins from eosinophils cultured with IL-5.

1992 • 127 citations

The role of interleukin-5 in protective immunity to Strongyloides venezuelensis infection in mice.

1991 • 126 citations

CBA/N Immune Defective Mice; Evidence for the Failure of a B Cell Subpopulation to be Expressed

1982 • 121 citations

Derivation of macrophage-like lines from the pre-B lymphoma ABLS 8.1 using 5-azacytidine

1982 • 121 citations

Human Interleukin‐3 inhibits the binding of granulocyte‐macrophage colony‐stimulating factor and interleukin‐5 to basophils and strongly enhances their functional activity

1990 • 121 citations

Antigen-induced T cell-replacing factor (TRF). I. Functional characterization of a TRF-producing helper T cell subset and genetic studies on TRF production.

1980 • 118 citations

Cloning of the low-affinity murine granulocyte-macrophage colony-stimulating factor receptor and reconstitution of a high-affinity receptor complex.

1992 • 117 citations

Factors Controlling the B-Cell Cycle

1986 • 116 citations

Distribution of IL-5 receptor-positive B cells. Expression of IL-5 receptor on Ly-1(CD5)+ B cells.

1990 • 116 citations

Molecular basis of a high affinity murine interleukin-5 receptor.

1991 • 112 citations

Eosinophilia and resistance to Schistosoma haematobium in man

1985 • 112 citations

Anti-IL-5 monoclonal antibody inhibits allergic late phase bronchial eosinophilia in guinea pigs: a therapeutic approach

1992 • 112 citations

Reconstitution of the functional receptors for murine and human interleukin 5.

1993 • 111 citations

Late-phase Asthmatic Reaction to Inhaled Allergen Is Associated with Early Recruitment of Eosinophils in the Airways

1991 • 110 citations

T Cell‐Derived Lymphokines That Induce IgM and IgG Secretion in Activated Murine B Cells

1984 • 109 citations

Enhancement of the interleukin 2 receptor expression on T cells by multiple B-lymphotropic lymphokines

1987 • 108 citations

Parallel regulation of IL-4 and IL-5 in human helminth infections.

1992 • 108 citations

Close genetic and physical linkage between the murine haemopoietic growth factor genes GM-CSF and Multi-CSF (IL3).

1987 • 107 citations

T cells from eosinophilic patients produce interleukin-5 with interleukin-2 stimulation

1989 • 106 citations

The effects of IL-4 and IL-5 on the IgA response by murine Peyer's patch B cell subpopulations.

1988 • 105 citations

Characterization of a receptor for interleukin 5 on human eosinophils: variable expression and induction by granulocyte/macrophage colony-stimulating factor.

1990 • 104 citations

The amino-terminal helix of GM-CSF and IL-5 governs high affinity binding to their receptors.

1991 • 103 citations

Enhancement of human basophil histamine release by interleukin 5.

1990 • 103 citations

Elevated serum levels of interleukin-5 in patients with the syndrome of episodic angioedema and eosinophilia

1992 • 103 citations

Monoclonal antibodies reactive with the mouse interleukin 5 receptor.

1989 • 103 citations

IL-1 activates two separate signal transduction pathways in T helper type II cells.

1990 • 101 citations

BCGFII activity on activated B cells of a purified murine T cell-replacing factor (TRF) from a T cell hybridoma (B151K12).

1985 • 100 citations

Characterization of high-affinity receptors for interleukin 5 on interleukin 5-dependent cell lines.

1989 • 99 citations

Effect of anti-IL-5 monoclonal antibody on allergic bronchial eosinophilia and airway hyperresponsiveness in mice

1993 • 98 citations

Hypodense eosinophils and interleukin 5 activity in the blood of patients with the eosinophilia-myalgia syndrome.

1990 • 97 citations

Isolation, structure and expression of cDNA and genomic clones for murine eosinophil differentiation factor

1988 • 96 citations

Observations on possible immunity to reinfection among Kenyan schoolchildren after treatment for Schistosoma mansoni

1983 • 96 citations

Recombinant soluble human interleukin-5 (hIL-5) receptor molecules. Cross-linking and stoichiometry of binding to IL-5.

1993 • 92 citations

Basophil and mast cell lineages in vitro and in vivo [published erratum appears in Blood 1992 Aug 1;80(3):855]

1992 • 91 citations

A two‐signal model for regulation of immunoglobulin isotype switching

1992 • 89 citations

Production of a monoclonal antibody useful in the molecular characterization of murine T-cell-replacing factor/B-cell growth factor II.

1987 • 88 citations

Characterization of the mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter: nuclear factors that interact with an element shared by three lymphokine genes--those for GM-CSF, interleukin-4 (IL-4), and IL-5.

1991 • 87 citations

Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells.

1990 • 86 citations

Reconstituted human granulocyte-macrophage colony-stimulating factor receptor transduces growth-promoting signals in mouse NIH 3T3 cells: comparison with signalling in BA/F3 pro-B cells.

1993 • 86 citations

The human interleukin-2 receptor β-chain gene: genomic organization, promoter analysis and chromosomal assignment

1990 • 85 citations

Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter.

1991 • 83 citations

Molecular cloning and structure of the human interleukin-5 gene.

1987 • 81 citations

Induction of B cell differentiation by T cell factors. I. Stimulation of IgM secretion by products of a T cell hybridoma and a T cell line.

1981 • 81 citations

Chromosomal localization and organization of the murine genes encoding the beta subunits (AIC2A and AIC2B) of the interleukin 3, granulocyte/macrophage colony-stimulating factor, and interleukin 5 receptors.

1992 • 80 citations

Interleultin‐2 treatment‐associated eosinophilia is mediated by interleultin‐5 production

1990 • 80 citations

Receptors for T cell-replacing factor/interleukin 5. Specificity, quantitation, and its implication.

1988 • 79 citations

Purification and physicochemical characterization of murine T cell replacing factor (TRF).

1985 • 79 citations

Recombinant interleukin 2 or 5, but not 3 or 4, induces maturation of resting mouse B lymphocytes and propagates proliferation of activated B cell blasts.

1988 • 77 citations

Interleukin-5

1992 • 77 citations

Differential regulation of IgA production by TGF-β and IL-5: TGF-β induces surface IgA-positive cells bearing IL-5 receptor, whereas IL-5 promotes their survival and maturation into IgA-secreting cells

1992 • 74 citations

Transforming growth factor-beta 1 is required for secretion of IgG of all subclasses by LPS-activated murine B cells in vitro.

1993 • 73 citations

Differential regulation of interleukin 4 and interleukin 5 gene expression: a comparison of T-cell gene induction by anti-CD3 antibody or by exogenous lymphokines.

1990 • 73 citations

T-cell-replacing factor (interleukin 5) induces expression of interleukin 2 receptors on murine splenic B cells.

1987 • 73 citations

Interleukin 5 is a differentiation factor for IgA B cells

1989 • 73 citations

Basophil and mast cell lineages in vitro and in vivo [published erratum appears in Blood 1992 Aug 1;80(3):855]

1992 • 72 citations

Characterization of the human IL-5 receptors on eosinophils

1991 • 70 citations

Interleukin 5 regulation of peritoneal Ly‐1 B lymphocyte proliferation, differentiation and autoantibody secretion

1989 • 69 citations

IL-5 receptor positive B cells, but not eosinophils, are functionally and numerically influenced in mice carrying the X-linked immune defect

1993 • 68 citations

Structure-function analysis of interleukin-5 utilizing mouse/human chimeric molecules.

1991 • 68 citations

Interleukin 5 and interleukin 3 induce serine and tyrosine phosphorylations of several cellular proteins in an interleukin 5-dependent cell line

1990 • 65 citations

Structure of Recombinant Human Interleukin 5 Produced by Chinese Hamster Ovary Cells

1990 • 64 citations

Interleukin-5 induces maturation but not class switching of surface IgA-positive B cells into IgA-secreting cells.

1989 • 63 citations

Interleukin 5 and its receptor

1991 • 63 citations

THE IMPORTANCE OF EOSINOPHIL CELLS IN KIDNEY ALLOGRAFT REJECTION

1988 • 62 citations

Epstein-Barr virus transformed B lymphocytes produce interleukin-5

1990 • 61 citations

Establishment of IL-5-Dependent Early B Cell Lines by Long-Term Bone Marrow Cultures

1989 • 60 citations

Role of carbohydrate moiety of IL-5. Effect of tunicamycin on the glycosylation of IL-5 and the biologic activity of deglycosylated IL-5.

1990 • 59 citations

In vivoadministration of antibody to murine IL-5 receptor inhibits eosinophilia of IL-5 transgenic mice

1991 • 57 citations

Characterization of a receptor for interleukin-5 on human eosinophils and the myeloid leukemia line HL-60

1991 • 56 citations

T Cell Replacing Factors in the B Cell Response to Antigen¹

1982 • 55 citations

Molecular properties and regulation of mRNA expression for murine T cell-replacing factor/IL-5.

1988 • 53 citations

Conversion of Normal Ly-1-Positive B-Lineage Cells into Ly-1-Positive Macrophages in Long-Term Bone Marrow Cultures

1990 • 53 citations

Characterization of the murine interleukin 5 receptor by using a monoclonal antibody

1990 • 53 citations

T cell-dependent hapten-specific and polyclonal B cell responses require release of interleukin 5.

1988 • 52 citations

Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis.

1991 • 52 citations

In vivo administration of antibody to interleukin-5 inhibits increased generation of eosinophils and their progenitors in bone marrow of parasitized mice

1990 • 50 citations

T-Cell-Dependent Accumulation of Eosinophils in the Lung and Its Inhibition by Monoclonal Anti-Interleukin-5

1991 • 49 citations

Mutated interleukin-5 monomers are biologically inactive

1991 • 49 citations

Interleukin 5 activity in sera from patients with eosinophilia

1990 • 48 citations

In vivo administration of antibody to interleukin-5 inhibits increased generation of eosinophils and their progenitors in bone marrow of parasitized mice

1990 • 47 citations

Novel protein-DNA interactions associated with increased immunoglobulin transcription in response to antigen plus interleukin-5.

1991 • 47 citations

Role of Interleukin-5 in Local Accumulation of Eosinophils in Mouse Allergic Peritonitis

1991 • 45 citations

Interleukin-5 is an autocrine growth factor for Epstein-Barr virus- transformed B lymphocytes

1992 • 44 citations

The Murine Interleukin-4 Receptor Gene: Genomic Structure, Expression and Potential for Alternative Splicing

1992 • 43 citations

Human interleukin‐5 induces staphylococcal A Cowan 1 strain‐activated human B cells to secrete IgM

1993 • 43 citations

Transforming growth factor-β1 (TGF-β1) is a bifunctional immune regulator for mucosal IgA responses

1990 • 42 citations

Role of CD4+ T lymphocytes and interleukin-5 in antigen-induced eosinophil recruitment into the site of cutaneous late-phase reaction in mice

1992 • 42 citations

Purification and Characterization of Recombinant Human Interleukin 5 Expressed in Chinese Hamster Ovary Cells

1989 • 42 citations

In vivo expression of interleukin 5 induces an eosinophilia and expanded Ly-1B lineage populations

1990 • 40 citations

Purification and partial sequence analysis of murine B cell growth factor II (interleukin 5).

1987 • 40 citations

Preparation and characterization of human interleukin-5 expressed in recombinant Escherichia coli

1990 • 40 citations

T cell replacing factor/interleukin 5 induces not only B-cell growth and differentiation, but also increased expression of interleukin 2 receptor on activated B-cells

1987 • 39 citations

Recombinant T cell replacing factor (interleukin 5) acts with antigen to promote the growth and differentiation of single hapten-specific B lymphocytes.

1987 • 33 citations

Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity.

1989 • 32 citations

Antigen-induced T cell-replacing factor (TRF). II. X-linked gene control for the expression of TRF-acceptor site(s) on B lymphocytes and preparation of specific antiserum to that acceptor.

1980 • 30 citations

Delayed progression of a murine retrovirus-induced acquired immunodeficiency syndrome in X-linked immunodeficient mice.

1993 • 30 citations

Structural comparison of murine T-cell (B151K12)-derived T-cell-replacing factor (IL-5) with RIL-5: Dimer formation is essential for the expression of biological activity

1990 • 30 citations

Molecular characterization of the β chain of the murine interleukin 5 receptor

1991 • 26 citations

Role of the C-terminus in the biological activity of human interleukin 5

1991 • 26 citations

CONSTITUTIVE GENE EXPRESSION OF INTERLEUKIN‐5 IN KIMURA'S DISEASE

1990 • 25 citations

DBA/2Ha Mice as a Model of an X‐Linked Immunodeficiency which is Defective in the Expression of TRF‐Acceptor Site(s) on B Lymphocytes

1982 • 25 citations

Rapid methods for purification of human recombinant interleukin-5 (IL-5) using the anti-murine IL-5 antibody-coupled immunoaffinity column

1989 • 24 citations

Biochemical and functional characterization of soluble form of IL-5 receptor α (sIL-5Rα) Development of ELISA system for detection of sIL-5Rα

1994 • 22 citations

Effect of recombinant interleukin 5 on the generation of cytotoxic T cells (CTL)

1991 • 21 citations

Localization of the gene encoding the α subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24–3p26

1992 • 20 citations

Role of recombinant interleukin-1 compared to recombinant T-cell replacing factor/interleukin-5 in B-cell differentiation.

1988 • 20 citations

IL-5 up-regulates but IL-4 down-regulates IL-2R expression on a cloned B lymphoma line.

1990 • 20 citations

The supportive effects of IL-7 on eosinophil progenitors from human bone marrow cells can be blocked by anti-IL-5.

1992 • 20 citations

Germinal center cells are a major IL-5-responsive B cell population in peripheral lymph nodes engaged in the immune response.

1990 • 19 citations

Characterization of the interleukin 5‐reactive splenic B cell population

1990 • 19 citations

Cytokine Receptors on Ly‐1 B Cells

1992 • 19 citations

Recombinant Human IL-5 Augments Immunoglobulin Generation by Human B Lymphocytes in the Presence of IL-2

1993 • 18 citations

Enhancing factor on anti-hapten antibody response released from PPDs-stimulated tubercle bacilli-sensitized cells

1974 • 17 citations

Comparative analysis of the kinetics of binding and internalization of IL-5 in murine IL-5 receptors of high and low affinity.

1993 • 17 citations

Role of T cell-replacing factor (TRF) in the murine B cell differentiation: induction of increased levels of expression of secreted type IgM mRNA.

1987 • 17 citations

Soluble receptors for IL-1 and IL-4: biological activity and therapeutic potential

1990 • 17 citations

Molecular Cloning and Structure of the Mouse Interleukin-5 Gene

1988 • 16 citations

Establishment of three PPD-reactive helper T cell clones with distinct functions in B cell activation.

1984 • 15 citations

In vivo desensitization to leukotriene B4 (LTB4) in the rabbit. Inhibition of LTB4-induced neutropenia during intravenous infusion of LTB4.

1993 • 15 citations

Mechanisms of the Interleukin 5-Induced Differentiation of B Cells1

1989 • 14 citations

Antibody against T cell-replacing factor acceptor site(s) augments in vivo primary IgM responses to suboptimal doses of heterologous erythrocytes

1981 • 14 citations

B-Cell Growth and Differentiation Factors

1988 • 14 citations

Interleukin-5 Levels of Pleural Fluid and Serum Samples in a Patient with PIE Syndrome

1992 • 13 citations

Acceptor site(s) for T cell-replacing factor (TRF) on B lymphocytes. I. TRF-substituting activity of anti-TRF acceptor site(s) antibody in the triggering of B cells.

1982 • 11 citations

Interferon-gamma inhibits the proliferation but not the differentiation of murine B cells in response to IL-5

1989 • 10 citations

LPS-activated CBA/N mouse B cells respond to anti-Ig and a BSF-1-like factor.

1986 • 10 citations

Maintenance of CD5⁺B Cells at an Early Developmental Stage by Interleukin-5: Evidence from Immunoglobulin Gene Usage in Interleukin-5 Transgenic Mice

1993 • 10 citations

Localization of the IL-5 receptor gene to the distal half of murine chromosome 6 using recombinant inbred strains of mice

1992 • 9 citations

X-linked recessive inheritance of a defective responsiveness to T-cell-replacing factor in DBA/2Ha mice

1981 • 8 citations

Acceptor site(s) for T cell-replacing factor (TRF) on B lymphocytes. II. Activation of B cells by cross-linkage or aggregation of the TRF acceptor molecule.

1982 • 8 citations

Synergetic effect of interleukin-2 and cellular cytotoxicity against a novel tumor-associated carbohydrate antigen Lea/Lea (dimeric Lea) mediated by monoclonal antibody NCC-ST-421 in adoptive immunization using SCID mice

1993 • 8 citations

Murine interleukin 5 receptor isolated by immunoaffinity chromatography: comparison of determined N-terminal sequence and deduced primary sequence from cDNA and implication of a role of the intracytoplasmic domain

1991 • 8 citations

Anti‐tumor Effects of Interleukin‐4 and Interleukin‐5 against Mouse B Cell Lymphoma and Possible Mechanisms of Their Action

1992 • 7 citations

Lymphokine-regulated differential expression of mRNA for p75kDa-IL-2R and p55kDa-IL-2R in a cloned B lymphoma line (BLC1-CL-3 cells).

1990 • 7 citations

IL-5-induced IgA synthesis by LPS-stimulated mouse B cells is prevented by protein kinase C inhibitors.

1992 • 6 citations

Coexpression of CD5 and IL‐5 Receptor on Peritoneal B Cells

1992 • 6 citations

Elevated Expression of Proto‐Oncogenes during Interleukin‐5‐Induced Growth and Differentiation of Murine B Lineage Cells

1990 • 6 citations

Three functionally distinct helper T-cell clones: the roles for antigen non-specific helper factors in B-cell activation through two different pathways.

1985 • 3 citations

Regulatory Mechanism of Reagin Production in Mice at the T Cell Level

1979 • 3 citations