Interleukin-5, eosinophils, and disease

Eosinophilic Inflammation in Asthma

1990 • 2,535 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

The cytokine handbook

1994 • 1,121 citations

Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions.

1985 • 1,065 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of asthma

1990 • 916 citations

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.

1991 • 841 citations

The Eosinophilic Leukocyte: Structure and Function

1986 • 828 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF

1989 • 676 citations

Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice

1989 • 635 citations

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1991 • 598 citations

Eosinophilia in transgenic mice expressing interleukin 5.

1990 • 579 citations

Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage

1987 • 384 citations

MECHANISM OF EOSINOPHILIA

1970 • 374 citations

IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner.

1990 • 328 citations

Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.

1991 • 303 citations

Detection of eosinophils using an eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors

1985 • 303 citations

Identification of a lymphokine that stimulates eosinophil differentiation in vitro. Its relationship to interleukin 3, and functional properties of eosinophils produced in cultures.

1985 • 296 citations

Human eosinophil, but not neutrophil, adherence to IL-1-stimulated human umbilical vascular endothelial cells is alpha 4 beta 1 (very late antigen-4) dependent.

1991 • 295 citations

Cell-Mediated Damage to Helminths

1985 • 289 citations

Molecular and Cellular Biology of Eosinophil Differentiation Factor (Interleukin‐5) and its Effects on Human and Mouse B Cells

1988 • 263 citations

Effects of recombinant human interleukin-3 in patients with normal hematopoiesis and in patients with bone marrow failure

1990 • 240 citations

Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni.

1990 • 238 citations

Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome.

1989 • 234 citations

A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor.

1989 • 198 citations

Murine eosinophil differentiation factor. An eosinophil-specific colony-stimulating factor with activity for human cells.

1986 • 170 citations

Eosinophils: A Comprehensive Review, and Guide to the Scientific and Medical Literature

1989 • 149 citations

Formation of eosinophilic‐like granulocytic colonies by mouse bone marrow cells in vitro

1974 • 148 citations

Identification of the second subunit of the murine interleukin-5 receptor: interleukin-3 receptor-like protein, AIC2B is a component of the high affinity interleukin-5 receptor.

1991 • 144 citations

The Clinical and Immunologic Responses of Normal Human Volunteers to Low Dose Hookworm (Necator americanus) Infection

1987 • 140 citations

Synergism among interleukin 1, interleukin 3, and interleukin 5 in the production of eosinophils from primitive hemopoietic stem cells.

1988 • 138 citations

Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils.

1991 • 136 citations

Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients.

1990 • 131 citations

The role of interleukin-5 in protective immunity to Strongyloides venezuelensis infection in mice.

1991 • 126 citations

Human Interleukin‐3 inhibits the binding of granulocyte‐macrophage colony‐stimulating factor and interleukin‐5 to basophils and strongly enhances their functional activity

1990 • 121 citations

Human eosinophil hematopoiesis studied in vitro by means of murine eosinophil differentiation factor (IL5): production of functionally active eosinophils from normal human bone marrow

1988 • 120 citations

Molecular basis of a high affinity murine interleukin-5 receptor.

1991 • 112 citations

Late-phase Asthmatic Reaction to Inhaled Allergen Is Associated with Early Recruitment of Eosinophils in the Airways

1991 • 110 citations

Nonneoplastic hematopoietic myeloproliferative syndrome induced by dysregulated multi-CSF (IL-3) expression

1989 • 109 citations

Repeated antigen inhalation results in a prolonged airway eosinophilia and airway hyperresponsiveness in primates

1990 • 108 citations

Experimental Asthma in Guinea Pigs Revisited

1984 • 106 citations

Monoclonal antibodies reactive with the mouse interleukin 5 receptor.

1989 • 103 citations

Hypodense eosinophils and interleukin 5 activity in the blood of patients with the eosinophilia-myalgia syndrome.

1990 • 97 citations

Isolation, structure and expression of cDNA and genomic clones for murine eosinophil differentiation factor

1988 • 96 citations

Observations on possible immunity to reinfection among Kenyan schoolchildren after treatment for Schistosoma mansoni

1983 • 96 citations

Regulation of human eosinophil precursor production by cytokines: a comparison of recombinant human interleukin-1 (rhIL-1), rhIL-3, rhIL-5, rhIL-6, and rh granulocyte-macrophage colony-stimulating factor

1990 • 92 citations

Basophil and mast cell lineages in vitro and in vivo [published erratum appears in Blood 1992 Aug 1;80(3):855]

1992 • 91 citations

Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells.

1990 • 86 citations

Interleultin‐2 treatment‐associated eosinophilia is mediated by interleultin‐5 production

1990 • 80 citations

Target cells for granulocyte colony-stimulating factor, interleukin-3, and interleukin-5 in differentiation pathways of neutrophils and eosinophils

1990 • 76 citations

Effects of recombinant human interleukin-3 on human hematopoietic progenitor and precursor cells in vivo

1990 • 71 citations

THE PROGNOSTIC VALUE OF THE EOSINOPHIL IN ACUTE RENAL ALLOGRAFT REJECTION

1986 • 70 citations

Colony-Stimulating Factors

2020 • 70 citations

Structure-function analysis of interleukin-5 utilizing mouse/human chimeric molecules.

1991 • 68 citations

Structure of Recombinant Human Interleukin 5 Produced by Chinese Hamster Ovary Cells

1990 • 64 citations

THE IMPORTANCE OF EOSINOPHIL CELLS IN KIDNEY ALLOGRAFT REJECTION

1988 • 62 citations

Immunopathology of schistosomiasis in athymic mice

1976 • 60 citations

TheIL-4 andIL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11

1989 • 57 citations

Characterization of a receptor for interleukin-5 on human eosinophils and the myeloid leukemia line HL-60

1991 • 56 citations

Mutated interleukin-5 monomers are biologically inactive

1991 • 49 citations

Eosinophil differentiation factor (interleukin-5).

1990 • 44 citations

BLOOD EOSINOPHILIA, STEROIDS, AND REJECTION

1985 • 39 citations

Local eosinophilia in stroma of tumors related to prognosis.

1984 • 35 citations

Detection of eosinophil differentiation factor and its relationship to eosinophilia in Mesocestoides corti-infected mice.

1986 • 34 citations

Infection of IL5 transgenic mice with Mesocestoides corti induces very high levels of IL5 but depressed production of eosinophils.

1992 • 34 citations

Extensive deposition of eosinophil peroxidase in Hodgkin's and non-Hodgkin's lymphomas.

1986 • 30 citations

Inflammatory Cells in Bronchial Asthma

1989 • 30 citations

Radiation-Related Eosinophilia

1975 • 27 citations

CONSTITUTIVE GENE EXPRESSION OF INTERLEUKIN‐5 IN KIMURA'S DISEASE

1990 • 25 citations

Human interleukin‐5 expressed in Escherichia coli: assignment of the disulfide bridges of the purified unglycosylated protein

1991 • 20 citations

Interaction of interleukin-5 with its receptors on murine leukemic BCL1 cells and its implication in biological activity

1990 • 16 citations

Production of Human and Murine Eosinophils In Vitro and Assay for Eosinophil Differentiation Factors

2003 • 11 citations

Analysis of interleukin 5 receptors on murine eosinophils: A comparison with receptors on B13 cells

1991 • 10 citations