T Cell‐Replacing Factor (TRF)/Interleukin 5 (IL‐5): Molecular and Functional Properties

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

Structure and expression of a cloned cDNA for human interleukin-2

1983 • 1,176 citations

Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

1982 • 1,095 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

T‐Cell Growth Factor

1980 • 917 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

The carrier effect in the secondary response to hapten‐protein conjugates. II. Cellular cooperation

1971 • 677 citations

B-Cell Stimulatory Factor-1/Interleukin 4

1987 • 602 citations

Replacement of T-Cell Function by a T-Cell Product

1972 • 537 citations

Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors.

1988 • 528 citations

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

1986 • 514 citations

Interleukin 2

1984 • 497 citations

Expression of interleukin 2 receptors on activated human B cells.

1984 • 488 citations

Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

1986 • 480 citations

T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.

1982 • 445 citations

Regulation of B-Cell Growth and Differentiation by Soluble Factors

1983 • 432 citations

Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1.

1985 • 410 citations

Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II

1986 • 405 citations

Activated B cells express receptors for, and proliferate in response to, pure interleukin 2.

1984 • 361 citations

Expression of Tac antigen on activated normal human B cells.

1984 • 355 citations

Factors Affecting B-Cell Growth and Differentiation

1985 • 354 citations

Immunoglobulin Genes

1983 • 341 citations

Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression.

1987 • 320 citations

Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage

1987 • 280 citations

Is There Evidence for a Non-Antigen Specific Diffusable Chemical Mediator from the Thymus-Derived Cell in the Initiation of the Immune Response?**Supported by U. S. Public Health Service Research Grant AI-08795-03 and American Cancer Society Research Grant E-395-D.

1971 • 276 citations

Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony-stimulating factor activities: relationship to interleukin 5.

1987 • 236 citations

Cloning of cDNA for human T-cell replacing factor (interieukin-5) and comparison with the murine homologue

1986 • 205 citations

Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays.

1983 • 204 citations

Eosinophil differentiation factor also has B-cell growth factor activity: proposed name interleukin 4.

1986 • 194 citations

Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes

1985 • 193 citations

Antigen-induced T cell-replacing factor (TRF). III. Establishment of T cell hybrid clone continuously producing TRF and functional analysis of released TRF.

1980 • 166 citations

Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor.

1982 • 140 citations

Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes.

1987 • 140 citations

Characterization of the high-affinity cell-surface receptor for murine B-cell-stimulating factor 1.

1987 • 140 citations

B cell activation: Three steps and their variations

1984 • 130 citations

Antigen-induced T cell-replacing factor (TRF). I. Functional characterization of a TRF-producing helper T cell subset and genetic studies on TRF production.

1980 • 118 citations

Mechanisms of T Cell-B Cell Interaction

1983 • 117 citations

Factors Controlling the B-Cell Cycle

1986 • 116 citations

T Cell‐Derived Lymphokines That Induce IgM and IgG Secretion in Activated Murine B Cells

1984 • 109 citations

Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis.

1984 • 106 citations

Soluble factors involved in B cell differentiation: identification of two distinct T cell-replacing factors (TRF).

1983 • 101 citations

BCGFII activity on activated B cells of a purified murine T cell-replacing factor (TRF) from a T cell hybridoma (B151K12).

1985 • 100 citations

Production of a monoclonal antibody useful in the molecular characterization of murine T-cell-replacing factor/B-cell growth factor II.

1987 • 88 citations

Induction of B cell differentiation by T cell factors. I. Stimulation of IgM secretion by products of a T cell hybridoma and a T cell line.

1981 • 81 citations

Purification and physicochemical characterization of murine T cell replacing factor (TRF).

1985 • 79 citations

The Synergism of Aecessory Cells and of Soluble a‐Factors Derived from Them in the Activation of B Cells to Proliferation

1984 • 78 citations

Recombinant interleukin 2 or 5, but not 3 or 4, induces maturation of resting mouse B lymphocytes and propagates proliferation of activated B cell blasts.

1988 • 77 citations

Three restriction points in the cell cycle of activated murine B lymphocytes.

1985 • 74 citations

T-cell-replacing factor (interleukin 5) induces expression of interleukin 2 receptors on murine splenic B cells.

1987 • 73 citations

Role of BCGFII in the differentiation to antibody secretion normal and tumor B cells.

1985 • 71 citations

Interleukin 4 (B-cell growth factor II/eosinophil differentiation factor) is a mitogen and differentiation factor for preactivated murine B lymphocytes.

1986 • 70 citations

Interaction and Activation of Antigen‐Specific T and B Cells

1987 • 59 citations

T‐Independent Activation of Single B Cells: An Orderly Analysis of Overlapping Stages in the Activation Pathway

1987 • 55 citations

Human interleukin 2 can promote the growth and differentiation of single hapten-specific B cells in the presence of specific antigen.

1984 • 55 citations

Molecular properties and regulation of mRNA expression for murine T cell-replacing factor/IL-5.

1988 • 53 citations

Regulation of B-Cell Differentiation: Interactions of Factors and Corresponding Receptors

1986 • 52 citations

T cell-dependent hapten-specific and polyclonal B cell responses require release of interleukin 5.

1988 • 52 citations

Ig RNA expression in normal B cells stimulated with anti-IgM antibody and T cell-derived growth and differentiation factors.

1984 • 50 citations

Partial purification and characterization of a BCGFII from EL4 culture supernatants.

1984 • 42 citations

T cell replacing factor/interleukin 5 induces not only B-cell growth and differentiation, but also increased expression of interleukin 2 receptor on activated B-cells

1987 • 39 citations

Recombinant T cell replacing factor (interleukin 5) acts with antigen to promote the growth and differentiation of single hapten-specific B lymphocytes.

1987 • 33 citations

Control of the Cell Cycle of Murine B Lymphocytes: The Nature of α‐ and β‐B‐Cell Growth Factors and of B‐Cell Maturation Factors

1987 • 32 citations

Effect of T cell-derived lymphokines containing B cell differentiation factor(s) for IgG (BCDF gamma) on gamma-specific mRNA in murine B cells.

1983 • 30 citations

DBA/2Ha Mice as a Model of an X‐Linked Immunodeficiency which is Defective in the Expression of TRF‐Acceptor Site(s) on B Lymphocytes

1982 • 25 citations

Antibody production in mice: IV. The suppressive effect of anti-hapten and anti-carrier antibodies on the recognition of hapten-carrier conjugate in the secondary response

1971 • 25 citations

Role of T cell-replacing factor (TRF) in the murine B cell differentiation: induction of increased levels of expression of secreted type IgM mRNA.

1987 • 17 citations

Enhancing factor on anti-hapten antibody response released from PPDs-stimulated tubercle bacilli-sensitized cells

1974 • 17 citations

Activation of the gamma 1 gene by lipopolysaccharide and T cell-derived lymphokines containing a B cell differentiation factor for IgG1 (BCDF gamma).

1985 • 16 citations

Establishment of three PPD-reactive helper T cell clones with distinct functions in B cell activation.

1984 • 15 citations

Functional characterization of the killer-helper factor responsible for the induction of cytotoxic T lymphocytes from thymocytes, and evidence for the nature of this factor as distinct from T cell-replacing factor (TRF) in regard to B cell triggering.

1981 • 15 citations

Generation of cytotoxic T lymphocytes from thymocyte precursors to trinitrophenyl-modified self antigens. II. Establishment of a T cell hybrid clone constitutively producing killer-helper factor(s) (KHF) and functional analysis of released KHF.

1986 • 10 citations

Establishment of an Assay System for the Detection of Translated Materials of T Cell‐Replacing Factor mRNA in Xenopus Oocytes

1986 • 2 citations