DBA/2Ha Mice as a Model of an X‐Linked Immunodeficiency which is Defective in the Expression of TRF‐Acceptor Site(s) on B Lymphocytes

Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

1961 • 3,881 citations

FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES

1973 • 1,046 citations

The carrier effect in the secondary response to hapten‐protein conjugates. II. Cellular cooperation

1971 • 677 citations

Replacement of T-Cell Function by a T-Cell Product

1972 • 537 citations

A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes.

1978 • 488 citations

CELL INTERACTIONS BETWEEN HISTOINCOMPATIBLE T AND B LYMPHOCYTES

1973 • 431 citations

THE REQUIREMENT OF MORE THAN ONE ANTIGENIC DETERMINANT FOR IMMUNOGENICITY

1969 • 412 citations

Direct demonstration that receptor crosslinking or aggregation is important in insulin action

1978 • 388 citations

Membrane Immunoglobulins and Antigen Receptors on B and T Lymphocytes

1974 • 382 citations

The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.

1975 • 364 citations

GENETIC CONTROL OF RESPONSES TO BACTERIAL LIPOPOLYSACCHARIDES IN MICE

1974 • 354 citations

GENETIC CONTROL OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE IN MICE

1972 • 349 citations

Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.

1978 • 316 citations

Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines.

1979 • 301 citations

Opinion

1978 • 283 citations

Local aggregation of hormone–receptor complexes is required for activation by epidermal growth factor

1979 • 277 citations

Is There Evidence for a Non-Antigen Specific Diffusable Chemical Mediator from the Thymus-Derived Cell in the Initiation of the Immune Response?**Supported by U. S. Public Health Service Research Grant AI-08795-03 and American Cancer Society Research Grant E-395-D.

1971 • 276 citations

PPD Tuberculin—a B-Cell Mitogen

1972 • 267 citations

CARRIER FUNCTION IN ANTI-HAPTEN IMMUNE RESPONSES

1970 • 265 citations

Functional Specificity of Thymus-Dependent Lymphocytes

1977 • 256 citations

SUPPRESSION OF IMMUNOGLOBULIN CLASS SYNTHESIS IN MICE

1972 • 240 citations

ACTIVATION OF T AND B LYMPHOCYTES IN VITRO

1974 • 231 citations

X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells.

1975 • 216 citations

B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens.

1977 • 212 citations

X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect.

1975 • 200 citations

T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.

1980 • 191 citations

CELL INTERACTIONS BETWEEN HISTOINCOMPATIBLE T AND B LYMPHOCYTES

1973 • 190 citations

Restricted helper function of F1 hybrid T cells positively selected to heterologous erythrocytes in irradiated parental strain mice. II. Evidence for restrictions affecting helper cell induction and T-B collaboration, both mapping to the K-end of the H-2 complex.

1978 • 185 citations

Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice.

1977 • 178 citations

Interleukin 2: A Class of T Cell Growth Factors

1980 • 178 citations

Regulation by the H-2 gene complex of macrophage-lymphoid cell interactions in secondary antibody responses in vitro.

1976 • 176 citations

Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide

1977 • 173 citations

Induction and Suppression of Polyclonal Antibody Responses by Anti‐Ig Reagents and Antigen‐Nonspecific Helper Factors:

1980 • 169 citations

Antigen-induced T cell-replacing factor (TRF). III. Establishment of T cell hybrid clone continuously producing TRF and functional analysis of released TRF.

1980 • 166 citations

B cell helper factors. I. Requirement for both interleukin 2 and another 40,000 mol wt factor.

1981 • 159 citations

Concanavalin A-inducible, interleukin-2-producing T cell hybridoma.

1980 • 158 citations

Proliferation of Murine Thymic Lymphocytes in Vitro Is Mediated by the Concanavalin A-Induced Release of a Lymphokine (Costimulator)

1976 • 151 citations

ANTIGEN-SPECIFIC T-CELL FACTOR IN CELL COOPERATION: PHYSICAL PROPERTIES AND MAPPING IN THE LEFT-HAND (K) HALF OF H-2

1974 • 141 citations

Stoichiometry, inhibitor sensitivity, and organization of manganese associated with photosynthetic oxygen evolution

1981 • 139 citations

Evidence for an immunoglobulin-dependent antigen-specific helper T cell.

1977 • 130 citations

Cellular and genetic control of antibody responses. V. Helper T-cell recognition of H-2 determinants on accessory cells but not B cells.

1979 • 128 citations

B Lymphocyte: Activation by Insoluble Anti-Immunoglobulin: Induction of Immunoglobulin Secretion by a T Cell-Dependent Soluble Factor

1979 • 128 citations

Culture supernatants of a stimulated T-cell line have helper activity that acts synergistically with interleukin 2 in the response of B cells to antigen.

1981 • 119 citations

Antigen-induced T cell-replacing factor (TRF). I. Functional characterization of a TRF-producing helper T cell subset and genetic studies on TRF production.

1980 • 118 citations

The role of H-2 linked genes in helper T-cell function. II. Isolation on antigen-pulsed macrophages of two separate populations of F1 helper T cells each specific for antigen and one set of parental H-2 products.

1978 • 118 citations

T cell-dependent activation of resting B cells: requirement for both nonspecific unrestricted and antigen-specific Ia-restricted soluble factors.

1981 • 115 citations

X-linked B-lymphocyte defect in CBA/N mice. III. Abnormal development of B-lymphocyte populations defined by their density of surface immunoglobulin.

1976 • 115 citations

H‐2‐unrestricted polyclonal maturation without replication of small B cells induced by antigen‐activated T cell help factors

1980 • 112 citations

HAPTEN-SPECIFIC IgE ANTIBODY RESPONSES IN MICE

1973 • 100 citations

Macrophage Factor Controlling Differentiation of B Cells

1979 • 98 citations

A Third Signal in B Cell Activation Given by TRF

1975 • 95 citations

Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.

1975 • 94 citations

HAPTEN-SPECIFIC IgE ANTIBODY RESPONSES IN MICE

1973 • 85 citations

Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers.

1977 • 83 citations

Role of the major histocompatibility complex in T cell activation of B cell subpopulations. lyb-5(+) and lyb-5(-) B cell subpopulations differ in their requirement for major histocompatibility complex-restricted T cell recognition

1981 • 82 citations

Induction of B cell differentiation by T cell factors. I. Stimulation of IgM secretion by products of a T cell hybridoma and a T cell line.

1981 • 81 citations

Restricted helper function of F1 hybrid T cells positively selected to heterologous erythrocytes in irradiated parental strain mice. I. Failure to collaborate with B cells of the opposite parental strain not associated with active suppression.

1978 • 76 citations

The role of humoral factors in the initiation of in vitro primary immune responses. 3. Characterization of factors that replace thymus-derived cells.

1973 • 75 citations

Long-term culture of normal mouse B lymphocytes.

1981 • 73 citations

The role of H-2-linked genes in helper T-cell function. I. In vitro expression in B cells of immune response genes controlling helper T-cell activity

1977 • 71 citations

Regulation of Antibody Response in Vitro

1973 • 71 citations

Immunological unresponsiveness to thymus-independent antigens: two fundamentally different genetic mechanisms of B-cell unresponsiveness to dextran

1977 • 68 citations

Induction of B Cell Tolerance by Antigen Specific T Cell Factor

1973 • 67 citations

Conditions Determining the Generation and Expression of T Helper Cells

1977 • 64 citations

Functional analysis of T cells expressing Ia antigens. I. Demonstration of helper T-cell heterogeneity.

1979 • 60 citations

Role of a nonimmunoglobulin cell surface determinant in the activation of B lymphocytes by thymus-independent antigens.

1979 • 59 citations

T Cell Replacing Factors in the B Cell Response to Antigen¹

1982 • 55 citations

Antigen-Specific and Nonspecific Mediators of T Cell/B Cell Cooperation

1975 • 55 citations

The histocompatibility restrictions on macrophage T-helper cell interaction determine the histocompatibility restrictions on T-helper cell B-cell interaction.

1978 • 54 citations

Generation of T helper cells in vitro. IV. F1 T helper cells primed with antigen-pulsed parental macrophages are genetically restricted in their antigen-specific helper activity.

1978 • 48 citations

Nature of T-cell macrophage interaction in helper-cell induction in vitro. II. Two stages of T-helper-cell differentiation analyzed in irradiation and allophenic chimeras.

1979 • 48 citations

The Role of Humoral Factors in the Initiation of in Vitro Primary Immune Responses

1973 • 48 citations

Antigen-Specific and Nonspecific Mediators of T Cell/B Cell Cooperation

1976 • 47 citations

In vitro analysis of allogeneic lymphocyte interaction. I. Characterization and cellular origin of an Ia-positive helper factor- allogeneic effect factor

1977 • 45 citations

Antigen-specific and nonspecific mediatiors of T cell/B cell cooperation. II. Two helper T cells distinguished by their antigen sensitivities.

1976 • 39 citations

Mechanism of T-cell help in the immune response to soluble protein antigens II. Reconstitution of primary and secondary in vitro immune responses to dinitrophenyl-carrier conjugates by T-cell-replacing factor.

1977 • 37 citations

Induction of proliferation and differentiation of neoplastic B cells by anti-immunoglobulin and T-cell factors.

1981 • 36 citations

Cellular cooperation during in vivo anti-hapten antibody responses. III. The helper cell activity of activated thymocytes, of spleen cells treated with anti-theta serum, and of spleen cells from anti-thymocyte serum-treated or adult thymectomized donors.

1975 • 33 citations

Antigen-induced T cell-replacing factor (TRF). II. X-linked gene control for the expression of TRF-acceptor site(s) on B lymphocytes and preparation of specific antiserum to that acceptor.

1980 • 30 citations

Mechanism of T-cell help in the immune response to soluble protein antigens. I. Evidence for in situ generation and action of T-cell-replacing factor during the anamnestic response to dinitrophenyl keyhole limpet hemocyanin in vitro.

1977 • 27 citations

Reconstitution of T cell-depleted spleen cell populations by factors derived from T cells. 3. Mechanism of action of T cell-derived factors.

1973 • 26 citations

Antigen-Specific and Nonspecific Mediators of T Cell/B Cell Cooperation

1976 • 25 citations

The purified protein derivative of turberculin, a B-cell mitogen that distinguishes in its action resting, small B cells from activated B-cell blasts.

1979 • 24 citations

Reconstitution of T Cell-Depleted Spleen Cell Populations by Factors Derived from T Cells

1973 • 18 citations

Enhancing factor on anti-hapten antibody response released from PPDs-stimulated tubercle bacilli-sensitized cells

1974 • 17 citations

Functional characterization of the killer-helper factor responsible for the induction of cytotoxic T lymphocytes from thymocytes, and evidence for the nature of this factor as distinct from T cell-replacing factor (TRF) in regard to B cell triggering.

1981 • 15 citations

Antibody against T cell-replacing factor acceptor site(s) augments in vivo primary IgM responses to suboptimal doses of heterologous erythrocytes

1981 • 14 citations

The Life Style of B Cells -- Cellular Proliferation and the Invariancy of IgG

1977 • 13 citations

Acceptor site(s) for T cell-replacing factor (TRF) on B lymphocytes. I. TRF-substituting activity of anti-TRF acceptor site(s) antibody in the triggering of B cells.

1982 • 11 citations

X-linked recessive inheritance of a defective responsiveness to T-cell-replacing factor in DBA/2Ha mice

1981 • 8 citations