Transgenic mice in the study of cytokine function.

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

1989 • 1,097 citations

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

1992 • 1,002 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Cytokines in context.

1991 • 808 citations

Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.

1985 • 788 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

1990 • 714 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

In vivo administration of purified human interleukin 2. II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL 2.

1985 • 600 citations

IgG1 plasmacytosis in interleukin 6 transgenic mice.

1989 • 597 citations

Eosinophilia in transgenic mice expressing interleukin 5.

1990 • 579 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

1990 • 447 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

1991 • 407 citations

Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage

1987 • 384 citations

TNFα—A PIVOTAL ROLE IN RHEUMATOID ARTHRITIS?

1992 • 377 citations

Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation

1993 • 367 citations

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.

1993 • 345 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Dysregulated interleukin 6 expression produces a syndrome resembling Castleman's disease in mice.

1990 • 338 citations

Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo.

1991 • 315 citations

Interleukin-10

1992 • 303 citations

Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production.

1991 • 303 citations

Normal, Autoimmune, and Malignant CD5+ B Cells: The LY-1 B Lineage?

1988 • 302 citations

Identification of a lymphokine that stimulates eosinophil differentiation in vitro. Its relationship to interleukin 3, and functional properties of eosinophils produced in cultures.

1985 • 296 citations

Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor.

1989 • 280 citations

Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse.

1990 • 263 citations

Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice.

1993 • 255 citations

Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice.

1991 • 250 citations

Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.

1992 • 234 citations

Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome.

1989 • 234 citations

The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.

1992 • 228 citations

Interleukin 6: insights to its function in skin by overexpression in transgenic mice.

1992 • 221 citations

A case for cytokines as effector molecules in the resolution of virus infection

1993 • 216 citations

Localization of cells producing erythropoietin in murine liver by in situ hybridization [see comments]

1991 • 199 citations

A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor.

1989 • 198 citations

Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans.

1993 • 183 citations

Regression of an established tumor genetically modified to release granulocyte colony-stimulating factor requires granulocyte-T cell cooperation and T cell-produced interferon gamma.

1993 • 171 citations

Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes.

1992 • 151 citations

Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice.

1992 • 150 citations

Analysis of cytokine mRNA levels in interleukin‐4‐transgenic mice by quantitative polymerase chain reaction

1992 • 139 citations

Tumor necrosis factor (TNF-α) and lymphotoxin (TNF-β)

1992 • 136 citations

Polycythemia in transgenic mice expressing the human erythropoietin gene.

1989 • 135 citations

Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients.

1990 • 131 citations

Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas.

1992 • 128 citations

Immunodeficient mice recover from infection with vaccinia virus expressing interferon‐γ

1990 • 117 citations

Leukemia Inhibitory Factor—A Puzzling Polyfunctional Regulator

1992 • 113 citations

Growth factors in liver development, regeneration and carcinogenesis

1991 • 113 citations

Nonneoplastic hematopoietic myeloproliferative syndrome induced by dysregulated multi-CSF (IL-3) expression

1989 • 109 citations

Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor virus transforming growth factor-alpha. Characterization of mammary gland and skin proliferations.

1992 • 105 citations

Lymphotoxin, Tumor Necrosis Factor, and Gamma Interferon Are Cytostatic for Normal Human Keratinocytes

1989 • 97 citations

Interleukin‐4 transgenic mice of resistant background are susceptible to Leishmania major infection

1993 • 95 citations

Local production of tumor necrosis factor encoded by recombinant vaccinia virus is effective in controlling viral replication in vivo.

1991 • 93 citations

Constitutive synthesis of tumor necrosis factor in the thymus.

1992 • 93 citations

Cut, paste, and save: New approaches to altering specific genes in mice

1989 • 92 citations

Interleukin-2

1992 • 91 citations

Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes.

1993 • 90 citations

The role of interleukin 2 in autoimmunity

1989 • 89 citations

Interleukin 4 expressed in situ selectively alters thymocyte development.

1991 • 86 citations

Humoral immune functions in IL-4 transgenic mice.

1991 • 86 citations

Long-term exposure to retrovirally expressed granulocyte-colony-stimulating factor induces a nonneoplastic granulocytic and progenitor cell hyperplasia without tissue damage in mice.

1989 • 79 citations

Interleukin-5

1992 • 77 citations

Retrovirus-Mediated Transfer and Expression of the Interleukin-3 Gene in Mouse Hematopoietic Cells Result in a Myeloproliferative Disorder

1989 • 77 citations

Endogenous tumor necrosis factor alpha is required for enhanced antimicrobial activity against Toxoplasma gondii and Listeria monocytogenes in recombinant gamma interferon-treated mice

1992 • 71 citations

Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin‐2 in islet β cells

1992 • 71 citations

Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice

1988 • 70 citations

Tissue-specific, inducible and functional expression of the E alpha d MHC class II gene in transgenic mice.

1985 • 70 citations

Interferon-γ

1992 • 69 citations

Interleukin 5 regulation of peritoneal Ly‐1 B lymphocyte proliferation, differentiation and autoantibody secretion

1989 • 69 citations

Male sterility of transgenic mice carrying exogenous mouse interferon-beta gene under the control of the metallothionein enhancer-promoter.

1988 • 67 citations

Transgenic Animals

1989 • 67 citations

The interleukin-4 family of lymphokines

1992 • 67 citations

Eosinophils 1992

1992 • 63 citations

Transforming growth factor-β in the regulation of the immune response

1992 • 60 citations

In vivoadministration of antibody to murine IL-5 receptor inhibits eosinophilia of IL-5 transgenic mice

1991 • 57 citations

Interferon expression in the testes of transgenic mice leads to sterility.

1988 • 54 citations

Selective up-regulation of macrophage function in granulocyte-macrophage colony-stimulating factor transgenic mice.

1991 • 49 citations

Expansion of natural killer cells but not T cells in human interleukin 2/interleukin 2 receptor (Tac) transgenic mice.

1989 • 48 citations

The selective ablation of interleukin 2-producing cells isolated from transgenic mice.

1993 • 46 citations

Effects of the deregulated expression of human interleukin-2 in transgenic mice

1989 • 45 citations

Major histocompatibility complex class II hyperexpression on B cells in interleukin 4‐transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia

1991 • 42 citations

In vivo expression of interleukin 5 induces an eosinophilia and expanded Ly-1B lineage populations

1990 • 40 citations

The excess numbers of peritoneal macrophages in granulocyte-macrophage colony-stimulating factor transgenic mice are generated by local proliferation.

1992 • 40 citations

Divergent disease patterns in granulocyte-macrophage colony-stimulating factor transgenic mice associated with different transgene insertion sites.

1988 • 39 citations

Delayed allograft rejection in mice transgenic for a soluble form of the IL-4 receptor

1992 • 36 citations

The biosynthesis of tumor necrosis factor during pregnancy: studies with a CAT reporter transgene and TNF inhibitors.

1992 • 36 citations

Infection of IL5 transgenic mice with Mesocestoides corti induces very high levels of IL5 but depressed production of eosinophils.

1992 • 34 citations

Regulation of erythropoietin production.

1993 • 32 citations

Are bacterial endotoxins involved in autoimmunity by CD5+ (Ly-1+) B cells?

1989 • 31 citations

Immunological Self‐Tolerance: An Analysis Employing Cytokines or Cytokine Receptors Encoded by Transgenes or a Recombinant Vaccinia Virus

1991 • 27 citations

Macrophage products IL-1α, TNFα and bFGF may mediate multiple cytopathic effects in the developing eyes of GM-CSF transgenic mice

1990 • 25 citations

Induction of interferon-α by interferon-β, but not of interferon-β by interferon-α, in the mouse

1990 • 23 citations

Plasminogen activator in granulocyte-macrophage-CSF transgenic mice.

1992 • 22 citations

Developmental ocular disease in GM-CSF transgenic mice is mediated by autostimulated macrophages

1989 • 21 citations

GM-CSF Produced by Recombinant Vaccinia Virus or in GM-CSF Transgenic Mice Has No Effect In vivo on Murine Cutaneous Leishmaniasis

1988 • 20 citations

Elevated levels of GM-CSF and IL-1 in the serum, peritoneal and pleural cavities of GM-CSF transgenic mice.

1989 • 19 citations

Interleukin-7: a new hematopoietic growth factor.

1990 • 19 citations

Mechanisms contributing to the sex difference in levels of granulocyte-macrophage colony-stimulating factor in the urine of GM-CSF transgenic mice.

1988 • 15 citations

Enhanced viral resistance in transgenic mice expressing the human beta 1 interferon

1988 • 15 citations

Anti-bacterial activity of peritoneal cells from transgenic mice producing high levels of GM-CSF.

1990 • 15 citations

Expression of murine IL-2 receptor beta-chain on thymic and splenic lymphocyte subpopulations as revealed by the IL-2-induced proliferative response in human IL-2 receptor alpha-chain transgenic mice.

1990 • 12 citations

Analysis of T-cell subpopulations in human IL-2Rα transgenic mice: Expansion of Thy1.2- thymocytes and depletion of double-positive T-cell precursors

1989 • 10 citations

Maintenance of CD5⁺B Cells at an Early Developmental Stage by Interleukin-5: Evidence from Immunoglobulin Gene Usage in Interleukin-5 Transgenic Mice

1993 • 10 citations

Production of Transgenic Mice and Application to Immunology and Autoimmunity

1990 • 10 citations

Transgenic mice as models of hemopoiesis

1991 • 9 citations

Cytokine expression by recombinant viruses — a new vaccine strategy

1992 • 5 citations

Long term expression of IL-4 in vivo using retroviral-mediated gene transfer.

1992 • 5 citations