Interleukin 4 expressed in situ selectively alters thymocyte development.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Ribonucleic acid isolated by cesium chloride centrifugation

1974 • 2,263 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

1982 • 1,095 citations

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.

1985 • 1,052 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Selected methods in cellular immunology

1980 • 747 citations

Introns increase transcriptional efficiency in transgenic mice.

1988 • 733 citations

IL-4 is required to generate and sustain in vivo IgE responses.

1988 • 671 citations

Separation of Blood Leucocytes, Granulocytes and Lymphocytes

1974 • 667 citations

The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

1989 • 645 citations

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

1986 • 627 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

1986 • 480 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

T-cell and mast cell lines respond to B-cell stimulatory factor 1.

1986 • 381 citations

Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry.

1986 • 369 citations

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

1986 • 355 citations

B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells

1987 • 355 citations

T Cell Development in the Adult Murine Thymus: Changes in the Expression of the Surface Antigens Ly2, L3T4 and B2A2 during Development from Early Precursor Cells to Emigrants

1984 • 344 citations

Decreased production of interferon-gamma by human neonatal cells. Intrinsic and regulatory deficiencies.

1986 • 302 citations

Interleukin-induced increase in Ia expression by normal mouse B cells.

1984 • 293 citations

Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S).

1989 • 289 citations

Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes

1987 • 248 citations

Characteristics of the immunocompetent cells in the mouse thymus: Cell population changes during cortisone-induced atrophy and subsequent regeneration

1970 • 247 citations

B cell-stimulatory factor 1 (BSF-1) promotes growth of helper T cell lines.

1986 • 154 citations

Restricted production of interleukin 4 by activated human T cells.

1988 • 141 citations

The thymus has two functionally distinct populations of immature αβ+ T cells: One population is deleted by ligation of αβTCR

1989 • 140 citations

The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis.

1988 • 138 citations

Intrathymic maturation of murine T lymphocytes from CD8+ precursors.

1989 • 134 citations

Reduced interferon-gamma mRNA levels in human neonates. Evidence for an intrinsic T cell deficiency independent of other genes involved in T cell activation.

1986 • 118 citations

Interleukin 4 is a growth factor for activated thymocytes: possible role in T-cell ontogeny.

1987 • 116 citations

T Cell CD3-ζη Heterodimer Expression and Coupling to Phosphoinositide Hydrolysis

1988 • 113 citations

Cytokine receptors and B cell functions. I. Recombinant soluble receptors specifically inhibit IL-1- and IL-4-induced B cell activities in vitro.

1990 • 111 citations

Structure and expression of Ick transcripts in human lymphoid cells

1988 • 104 citations

Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma

1988 • 102 citations

Disruption of thymocyte development and lymphomagenesis induced by SV4O T-antigen

1990 • 91 citations

CD4: Collaborator in immune recognition and HIV infection

1990 • 86 citations

Growth-promoting activity of IL-1 alpha, IL-6, and tumor necrosis factor-alpha in combination with IL-2, IL-4, or IL-7 on murine thymocytes. Differential effects on CD4/CD8 subsets and on CD3+/CD3- double-negative thymocytes.

1990 • 84 citations

A soluble, high-affinity, interleukin-4-binding protein is present in the biological fluids of mice.

1990 • 79 citations

Thymocytes expressing CD8 differentiate into CD4+ cells following intrathymic injection.

1988 • 72 citations

Alpha beta T cell receptor and CD3 transduce different signals in immature T cells. Implications for selection and tolerance.

1989 • 72 citations

Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny.

1989 • 70 citations

Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4

1990 • 67 citations

Proliferation and production of IL-2 and B cell stimulatory factor 1/IL-4 in early fetal thymocytes by activation through Thy-1 and CD3.

1988 • 65 citations

Tumor necrosis factor-alpha and P40 induce day 15 murine fetal thymocyte proliferation in combination with IL-2.

1990 • 54 citations

The Thymus Dependency of Resistance to Pinworm Infection in Mice

1974 • 50 citations

Aging-Related Deficiency in Intracellular Calcium Response to Anti-CD3 or Concanavalin a in Murine T-cell Subsets

1990 • 42 citations

IL-4 (B cell stimulatory factor 1) exhibits thymocyte growth factor activity in the presence of IL-2.

1988 • 17 citations

Regulatory role of CD4/L3T4 molecules in IL-2 production by affecting intracellular Ca2+ concentration of T cell clone stimulated with soluble anti-CD3.

1990 • 14 citations

Responsiveness of fetal and adult CD4-, CD8- thymocytes to T cell activation.

1989 • 6 citations