Endogenous tumor necrosis factor alpha is required for enhanced antimicrobial activity against Toxoplasma gondii and Listeria monocytogenes in recombinant gamma interferon-treated mice

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Secretory products of macrophages.

1987 • 2,670 citations

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

1983 • 1,918 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES

1968 • 1,492 citations

The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection

1989 • 1,269 citations

Interferon-γ: the Major Mediator of Resistance Against Toxoplasma gondii

1988 • 1,150 citations

Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages.

1992 • 1,040 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.

1990 • 573 citations

Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection.

1985 • 555 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha.

1990 • 453 citations

Interferon-Gamma, the Activated Macrophage, and Host Defense Against Microbial Challenge

1988 • 428 citations

Evidence that tumor necrosis factor has an important role in antibacterial resistance.

1989 • 422 citations

Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells.

1989 • 405 citations

Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major.

1989 • 374 citations

Endogenous tumor necrosis factor (cachectin) is essential to host resistance against Listeria monocytogenes infection

1988 • 353 citations

Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

1988 • 337 citations

Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.

1989 • 320 citations

IFN-gamma-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-alpha.

1992 • 285 citations

In vivo administration of recombinant IFN-gamma induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections.

1988 • 256 citations

Protection of mice against the intracellular bacterium Listeria monocytogenes by recombinant immune interferon

1984 • 228 citations

The Purification and Characterization of Rat Gamma Interferon by Use of Two Monoclonal Antibodies

1986 • 204 citations

L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae.

1991 • 180 citations

Role of TNF and IL-1 in infections with Toxoplasma gondii.

1990 • 170 citations

Tumour necrosis factor (TNF alpha) in leishmaniasis. I. TNF alpha mediates host protection against cutaneous leishmaniasis.

1990 • 168 citations

Endogenous tumor necrosis factor, interleukin-6, and gamma interferon levels during Listeria monocytogenes infection in mice

1992 • 147 citations

Macrophage activation to kill Leishmania major: activation of macrophages for intracellular destruction of amastigotes can be induced by both recombinant interferon-gamma and non-interferon lymphokines.

1985 • 127 citations

Effector function of hepatocytes and Kupffer cells in the resolution of systemic bacterial infections

1992 • 97 citations

Human rTNF alpha augments anti-bacterial resistance in mice: potentiation of its effects by recombinant human rIL-1 alpha.

1990 • 53 citations

Protective immunity and granuloma formation are mediated by two distinct tumor necrosis factor alpha- and gamma interferon-dependent T cell-phagocyte interactions in murine listeriosis: dissociation on the basis of phagocyte adhesion mechanisms

1992 • 43 citations

Nitrite Production by Activated Murine Macrophages Correlates with Their Toxoplasmastatic Activity, Ia Antigen Expression, and Production of H2O2

1991 • 31 citations

Hydrocortisone Treatment of BCG‐Infected Mice Impairs the Activation and Enhancement of Antimicrobial Activity of Peritoneal Macrophages

1992 • 10 citations