Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes.

Adhesion receptors of the immune system

1990 • 6,585 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins

1989 • 2,045 citations

Stereological Principles for Morphometry in Electron Microscopic Cytology

1969 • 1,969 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)

1987 • 1,712 citations

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

1981 • 1,582 citations

Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus

1965 • 1,338 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Cytokines and endothelial cell biology

1990 • 1,275 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

1988 • 1,107 citations

ELAM-1 is an adhesion molecule for skin-homing T cells

1991 • 843 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

An endothelial ligand for L-Selectin is a novel mucin-like molecule

1992 • 660 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

Adhesion molecules controlling lymphocyte migration

1989 • 654 citations

Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes.

1988 • 639 citations

ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM

1988 • 631 citations

Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis

1990 • 581 citations

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis.

1989 • 578 citations

Cytotoxicity of Human p I 7 Interleukin-1 for Pancreatic Islets of Langerhans

1986 • 525 citations

Cloning of a lymphocyte homing receptor reveals a lectin domain

1989 • 522 citations

EVIDENCE FOR A LONG PREDIABETIC PERIOD IN TYPE I (INSULIN-DEPENDENT) DIABETES MELLITUS

1981 • 480 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

1987 • 451 citations

Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion.

1991 • 406 citations

Purification and physico-chemical characterization of rabbit tumor necrosis factor.

1980 • 386 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

Activation-independent binding of human memory T cells to adhesion molecule ELAM-1

1991 • 379 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Studies with the mutation, diabetes, in the mouse

1967 • 317 citations

Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity.

1987 • 305 citations

Destruction of Rat Islet Cell Monolayers by Cytokines: Synergistic Interactions of Interferon-γ, Tumor Necrosis Factor, Lymphotoxin, and Interleukin 1

1988 • 296 citations

Cytokine‐related syndrome following injection of anti‐CD3 monoclonal antibody: Further evidence for transient in vivo T cell activation

1990 • 267 citations

The diabetic syndrome of the ?BB? Wistar rat: Possible relevance to Type 1 (insulin-dependent) diabetes in man

1982 • 249 citations

Pancreatic islet-specific T-cell clones from nonobese diabetic mice.

1989 • 246 citations

Inhibition of murine T cell‐mediated cytolysis and T cell proliferation by a rat monoclonal antibody immunoprecipitating two lymphoid cell surface polypeptides of 94000 and 180000 molecular weight

1982 • 237 citations

IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans.

1988 • 235 citations

An explanation for the protective effect of the MHC class II I–E molecule in murine diabetes

1989 • 216 citations

Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice.

1989 • 180 citations

Molecular cloning of murine intercellular adhesion molecule (ICAM-1).

1989 • 155 citations

The Pathophysiology Of Tumor Necrosis Factors

1992 • 153 citations

The role of CD4+ and CD8+ T cells in the destruction of islet grafts by spontaneously diabetic mice.

1991 • 147 citations

Subcutaneous perfusion of tumor necrosis factor induces local proliferation of fibroblasts, capillaries, and epidermal cells, or massive tissue necrosis.

1990 • 147 citations

The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice

1989 • 146 citations

Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.

1990 • 134 citations

Cyclophosphamide-Induced Diabetes in NOD/WEHI Mice: Evidence for Suppression in Spontaneous Autoimmune Diabetes Mellitus

1989 • 122 citations

Streptozotocin-induced pancreatic insulitis in mice. Morphologic and physiologic studies.

1978 • 118 citations

The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: Role of the EGF domain in endothelial binding

1990 • 117 citations

The Pathology of Diabetes Mellitus

1967 • 109 citations

CD8+ T cell homing to the pancreas in the nonobese diabetic mouse is CD4+ T cell-dependent.

1991 • 108 citations

Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection.

1989 • 92 citations

Studies in the diabetic mutant mouse: I. Light microscopy and radioautography of pancreatic islets

1970 • 88 citations

Destruction of pancreatic islet cells by cytotoxic T lymphocytes in nonobese diabetic mice.

1989 • 73 citations

Islet Cytotoxicity of Interleukin 1: Influence of Culture Conditions and Islet Donor Characteristics

1987 • 72 citations

Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin‐2 in islet β cells

1992 • 71 citations

Constitutive activity of the tumor necrosis factor promoter is canceled by the 3' untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect.

1992 • 71 citations

Nucleotide sequence of the murine TNF locus, including the TNF-α (tumor necrosis factor) and TNF-β (lymphotoxin) genes

1987 • 69 citations

Regulation of MHC Protein Expression in Pancreatic β-Cells by Interferon-γ and Tumor Necrosis Factor-α

1988 • 67 citations

Migration of lymphocytes across specialized vascular endothelium : V. Production of a sulphated macromolecule by high endothelial cells in lymph nodes*

1982 • 66 citations

Untersuchungen zur Inselzell-Regeneration, Hyperplasie und zu intrainsul�ren zellul�ren Beziehungen wahrend eines Langzeit-Streptozotocin-Diabetes bei Ratten

1970 • 52 citations

Islet‐infiltrating T cell clones from non‐obese diabetic mice that promote or prevent accelerated onset diabetes

1991 • 49 citations

Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics

1987 • 22 citations

Morphometric and functional studies of islets in diabetes-prone BB/W rats that are discordant for overt diabetes

1989 • 4 citations