Purification and properties of heme-deficient hepatic soluble guanylate cyclase: Effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX

Tissue sulfhydryl groups

1959 • 25,130 citations

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

1981 • 1,624 citations

Evidence for the inhibitory role of guanosine 3', 5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators

1981 • 629 citations

Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.

1981 • 527 citations

Soluble guanylate cyclase purified from bovine lung contains heme and copper

1981 • 328 citations

Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins. Evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation.

1978 • 327 citations

Purifieation of a Soluble, Sodium‐Nitroprusside‐Stimulated Guanylate Cyclase from Bovine Lung

1981 • 147 citations

Electron paramagnetic resonance studies of nitrosyl ferrous heme complexes. Determination of an equilibrium between two conformations.

1980 • 142 citations

Electron paramagnetic resonance of nitric oxide-protoheme complexes with some nitrogenous base. Model systems of nitric oxide hemoproteins

1969 • 133 citations

Reversible inactivation of guanylate cyclase by mixed disulfide formation.

1981 • 132 citations

Purification of soluble guanylate cyclase from rat lung.

1979 • 119 citations

Electron spin resonance study of the role of NO . catalase in the activation of guanylate cyclase by NaN3 and NH2OH. Modulation of enzyme responses by heme proteins and their nitrosyl derivatives.

1979 • 96 citations

Effects of thiols, sugars, and proteins on nitric oxide activation of guanylate cyclase.

1979 • 90 citations

Reactions of Methæmo-Globin and Catalase with Peroxides and Hydrogen Donors

1954 • 79 citations

Coronary arterial relaxation and guanylate cyclase activation by cigarette smoke, N'-nitrosonornicotine and nitric oxide.

1980 • 74 citations

Evidence that regulation of hepatic guanylate cyclase activity involves interactions between catalytic site SH groups and both substrate and activator

1981 • 69 citations

Effects of thiol inhibitors on hepatic guanylate cyclase activity Evidence for the involvement of vicinal dithiols in the expression of basal and agonist-stimulated activity

1978 • 51 citations

Selective alterations in responsiveness of guanylate cyclase to activation by nitroso compounds during enzyme purification

1981 • 36 citations

Activation of guanylate cyclase in cerebral cortex of rat by hydroxylamine.

1977 • 34 citations

Rat brain guanylate cyclase. Purification, amphiphilic properties and immunological characterization

1981 • 29 citations

Production and properties of antibody to soluble guanylate cyclase purified from bovine brain

1980 • 19 citations

Reversible inactivation of soluble liver guanylate cyclase by disulfides

1981 • 18 citations

Activation of hepatic guanylate cyclase by nitrosyl-heme complexes

1981 • 17 citations

Structural basis for the conformational states of nitrosyl hemoglobins M Saskatoon and M Milwaukee. Influence of distal histidine residues on proximal histidine-iron bonds.

1980 • 10 citations