Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells.

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

1987 • 678 citations

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

1989 • 464 citations

Activation of a Cytosolic ADP-ribosyltransferase by Nitric Oxide-generating Agents

1989 • 349 citations

An L-arginine-dependent mechanism mediates kupffer cell inhibition of hepatocyte protein synthesis in vitro

1989 • 325 citations

Formation and release of nitric oxide from human neutrophils and HL‐60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B₄

1989 • 244 citations

Evidence that rat Kupffer cells stimulate and inhibit hepatocyte protein synthesis in vitro by different mechanisms

1989 • 73 citations

The L-Arginine Dependent Effector Mechanism Is Induced in Murine Adenocarcinoma Cells by Culture Supernatant From Cytotoxic Activated Macrophages

1988 • 63 citations

NG-methylated arginines; A convenient preparation of NG-methylarginine

1974 • 60 citations