Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins. Evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

Evidence that Peroxidation of Lysosomal Membranes Is Initiated by Hydroxyl Free Radicals Produced during Flavin Enzyme Activity

1973 • 663 citations

Cyclic GMP Metabolism and Involvement in Biological Regulation

1977 • 629 citations

Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation

1970 • 500 citations

Exchange of Heme among Hemoglobins and between Hemoglobin and Albumin

1968 • 413 citations

The kinetics and equilibria of the reactions of nitric oxide with sheep haemoglobin

1957 • 385 citations

Electromagnetic Properties of Hemoproteins

1972 • 344 citations

A Microsomal Iron-Porphyrin Activator of Rat Liver Tryptophan Pyrrolase

1961 • 256 citations

Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regulator of guanosine 3',5'-monophosphate formation.

1977 • 238 citations

Paramagnetic Resonance Study of Nitric Oxide Hemoglobin

1968 • 231 citations

The Nature and Mechanism of the Tryptophan Pyrrolase (Peroxidase-Oxidase) Reaction of Pseudomonas and of Rat Liver

1959 • 213 citations

Activation of cerebral guanylate cyclase by nitric oxide

1977 • 212 citations

Calcium-Independent Modulation of Cyclic GMP and Activation of Guanylate Cyclase by Nitrosamines

1976 • 160 citations

Activation of soluble guanylate cyclase from rat lung by incubation or by hydrogen peroxide.

1976 • 147 citations

Nitroprusside produces cyanide poisoning via reaction with hemoglobin.

1974 • 136 citations

Electron paramagnetic resonance of nitric oxide-protoheme complexes with some nitrogenous base. Model systems of nitric oxide hemoproteins

1969 • 133 citations

Stimulation of human platelet guanylate cyclase by fatty acids.

1977 • 126 citations

Stimulation of human platelet guanylate cyclase by unsaturated fatty acid peroxides.

1977 • 110 citations

The Oxygen Effect on Deoxyribonucleic Acid Inactivation by Hydroxylamines^*

1965 • 96 citations

The reactions of azide with catalase and their significance

1964 • 95 citations

Isolation and identification of a paramagnetic complex from the livers of carcinogen-treated rats

1970 • 92 citations

Reactions of cysteine with N-methyl-N-nitroso-p-toluenesulfonamide and N-methyl-N′-nitro-N-nitrosoguanidine

1969 • 91 citations

An interpretation of the three line EPR spectrum of nitric oxide hemeproteins and related model systems:

1975 • 81 citations

Characterization of protein inhibitors of guanylate cyclase activation from rat heart and bovine lung

1978 • 71 citations

Purification and properties of a protein required for sodium azide activation of guanylate cyclase.

1977 • 68 citations

The Soret band of monomeric hematin and its changes on polymerization

1962 • 67 citations

Activation of hepatic guanylate cyclase by N-methyl-N'-nitro-N-nitrosoguanidine. Effects of thiols, N-ethylmaleimide, and divalent cations.

1977 • 56 citations

Effects of thiol inhibitors on hepatic guanylate cyclase activity Evidence for the involvement of vicinal dithiols in the expression of basal and agonist-stimulated activity

1978 • 51 citations

Oxygen and cyclic nucleotides in human umbilical artery.

1975 • 48 citations

The effects of 2-acetylaminofluorene and nitrite on free radicals and carcinogenesis in rat liver.

1970 • 46 citations

Dissociation of Hematin from Hemoproteins at Neutral pH

1960 • 44 citations

Chain equivalence in reaction of nitric oxide with hemoglobin.

1977 • 43 citations

FREE RADICAL INDUCED IN RAT LIVER BY A CHEMICAL CARCINOGEN, N‐METHYL‐N′‐NITRO‐N‐NITROSOGUANIDINE *

1973 • 39 citations

Properties and subcellular distribution of guanylate cyclase activity in rat renal medulla: correlation with tissue content of guanosine 3',5'-monophosphate

1976 • 37 citations

Inhibition by retinol and butylated hydroxyanisole of carcinogen-mediated increases in guanylate cyclase activity and guanosine 3':5'-monophosphate accumulation.

1977 • 35 citations

Periodate-induced increase in cyclic GMP in mouse and guinea pig splenic cells in association with mitogenesis

1976 • 35 citations

The resolution and activation of hematin-free trypophan pyrrolase from rat liver

1964 • 29 citations

Activation of the renal cortical and hepatic guanylate cyclase-guanosine 3′,5′-monophosphate systems by nitrosoureas divalent cation requirements and relationship to thiol reactivity

1977 • 24 citations

Electron spin resonance study of the role of nitrosyl-heme in the activation of guanylate cyclase by nitrosoguanidine and related agonists

1978 • 22 citations

Chromatographic separation of cyclic guanosine 3′,5′-monophosphate from guanylate cyclase reaction mixtures

1976 • 20 citations

Alterations in rat renal cortical and medullary guanosine 3′5′-monophosphate accumulation by oxygen- and calcium-dependent and -independent mechanisms: Evidence for a calcium-independent action of oxygen in renal inner medulla

1978 • 16 citations

Stimulation of Soluble Guanylate Cyclase Activity and Cellular Accumulation of Cyclic Guanosine 3′ ,5′-monophosphate by the Carcinogen 4-Nitroquinoline 1-oxide: Brief Communication 2

1977 • 14 citations

Activation of the guanylate cyclase-guanosine 3′5′ monophosphate system of colonic mucosa by N-methyl-N′-nitro-n-nitrosoguanidine

1977 • 14 citations

[Paramagnetic nitrosyl complexes of heme and nonheme iron].

1968 • 12 citations

[Endogenous nitrosyl complexes of heme and non-heme iron in microorganisms and animal tissues].

1971 • 12 citations

Nitrosyl haemoglobin: The no-spin as a relaxation probe in the solvent-proton magnetic resonance experiment demonstrating the phosphate-induced widening of the haem-pocket

1976 • 8 citations