Reduced plasma transforming growth factor-β1 levels in patients with chronic hepatitis C after interferon-α therapy: association with regression of hepatic fibrosis

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Classification of chronic hepatitis: Diagnosis, grading and staging

1994 • 2,506 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Treatment of Chronic Hepatitis C with Recombinant Interferon Alfa

1989 • 1,658 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Recombinant Interferon Alfa Therapy for Chronic Hepatitis C

1989 • 1,233 citations

Treatment of Chronic Non-A, Non-B Hepatitis with Recombinant Human Alpha Interferon

1986 • 980 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

Transforming Growth Factors β1 and α in Chronic Liver Disease

1991 • 655 citations

Detection of hepatitis C viral sequences in blood donations by "nested" polymerase chain reaction and prediction of infectivity

1990 • 569 citations

Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5'-noncoding region.

1990 • 548 citations

Non-A, non-B hepatitis. I. Recognition, epidemiology, and clinical features

1983 • 506 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction.

1980 • 461 citations

In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis.

1989 • 420 citations

Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis.

1990 • 354 citations

Selective inhibition of human diploid fibroblast collagen synthesis by interferons.

1984 • 336 citations

Recombinant human α-interferon in patients with chronic non-A, non-B hepatitis: A multicenter randomized controlled trial from France

1991 • 320 citations

7‐S Collagen: Characterization of an Unusual Basement Membrane Structure

1980 • 304 citations

Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor β: Implication for a pathogenetic role in alcoholic liver fibrogenesis

1990 • 295 citations

Plasma transforming growth factor-β1 in patients with hepatocellular carcinoma. Comparison with chronic liver diseases

1994 • 215 citations

Long-term follow-up of acute and chronic non-A, non-B post-transfusion hepatitis: evidence of progression to liver cirrhosis.

1982 • 187 citations

The N-Terminal Propeptide of Collagen Type III in Serum Reflects Activity and Degree of Fibrosis in Patients with Chronic Liver Disease

1984 • 185 citations

Interferon alfa and gamma inhibit proliferation and collagen synthesis of human ito cells in culture

1995 • 181 citations

Interferon-alpha 2b therapy reduces liver fibrosis in chronic non-A, non-B hepatitis: a quantitative histological evaluation.

1993 • 147 citations

Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver.

1990 • 144 citations

Regulation of TGFβ gene expression in rat liver intoxicated with carbon tetrachloride

1990 • 137 citations

Randomised controlled trial of interferon alfa (lymphoblastoid interferon) in chronic non-A non-B hepatitis.

1989 • 125 citations

ALPHA-INTERFERON THERAPY FOR NON-A, NON-B HEPATITIS TRANSMITTED BY GAMMAGLOBULIN REPLACEMENT THERAPY

1987 • 119 citations

Interferon-α2b therapy reduces liver fibrosis in chronic non-A, non-B hepatitis: A quantitative histological evaluation

1993 • 106 citations

Hepatic Fibrosis

1979 • 105 citations

Liver fibrosis and extracellular matrix

1989 • 94 citations

Quantitative analysis of transforming growth factor β1 messenger RNA in the liver of patients with chronic hepatitis C: Absence of correlation between high levels and severity of disease

1995 • 57 citations

Changes in serum fibrogenesis markers during interferon therapy for chronic hepatitis type C

1996 • 48 citations

Long-term decrease in serum N-terminal propeptide of type III procollagen in patients with chronic hepatitis C treated with interferon alfa

1995 • 45 citations

Transforming growth factor beta 1: in situ expression in the liver of patients with chronic hepatitis C treated with alpha interferon.

1993 • 26 citations

Serial determinations of the amino-terminal peptide of type III procollagen in severe chronic active hepatitis.

1987 • 21 citations

Comparative efficacy of a high or low dose of interferon alpha 2b in chronic hepatitis C: a randomized controlled trial.

1996 • 20 citations

Multiple Interferon Subtypes: The Phenomenon and Its Relevance

1987 • 19 citations

Decrease in serum levels of markers of hepatic connective tissue turnover during and after treatment of chronic hepatitis B with interferon-alpha.

1994 • 16 citations

Decrease in serum levels of markers of hepatic connective tissue turnover during and after treatment of chronic hepatitis B with interferon-α

1994 • 14 citations

Modulation of Collagen Synthesis and Degradation by Retinoids and Cytokines in 3T3 L1 Preadipocytes.

1994 • 7 citations

Plasma transforming growth factor-? (TGF-?) levels in hepatic fibrosis Duke University Medical Center, Durham, NC, Department of Medicine, *Department of Pathology, #Department of Radiation Oncology

1995 • 1 citations