Limb deformity proteins: role in mesodermal induction of the apical ectodermal ridge

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

1995 • 1,175 citations

The proximo‐distal sequence of origin of the parts of the chick wing and the role of the ectoderm

1948 • 1,101 citations

Expression of a Delta homologue in prospective neurons in the chick

1995 • 1,019 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb

1993 • 660 citations

Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development

1996 • 588 citations

Fibroblast growth factors induce additional limb development from the flank of chick embryos

1995 • 578 citations

FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development

1994 • 470 citations

Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.

1990 • 458 citations

Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development

1991 • 410 citations

FGF-4 and BMP-2 have opposite effects on limb growth

1993 • 377 citations

A quantitative analysis of the effect of excision of the AER from the chick limb-bud

1974 • 376 citations

Involvement of FGF8 in initiation, outgrowth and patterning of the vertebrate limb

1996 • 335 citations

Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb

1996 • 314 citations

An inherited limb deformity created by insertional mutagenesis in a transgenic mouse

1985 • 294 citations

Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis

1990 • 266 citations

A staging system for mouse limb development

1989 • 221 citations

Vertebrate Limb Development

1994 • 204 citations

'Formins': proteins deduced from the alternative transcripts of the limb deformity gene

1990 • 201 citations

FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro

1993 • 151 citations

Analysis of mouse Evx genes: Evx-1 displays graded expression in the primitive streak

1992 • 141 citations

Tissue patterning in the developing mouse limb.

1990 • 137 citations

An Additional Limb Can Be Induced from the Flank of the Chick Embryo by FGF4

1995 • 105 citations

Distinct expression patterns of insulin-like growth factor binding proteins 2 and 5 during fetal and postnatal development.

1994 • 104 citations

The limb deformity gene is required for apical ectodermal ridge differentiation and anteroposterior limb pattern formation.

1989 • 78 citations

The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5′ HoxD genes during limb pattern formation

1995 • 72 citations

The development of the vertebrate limb : an approach through experiment, genetics, and evolution

1980 • 68 citations

Insulin-like growth factor I and II and insulin-like growth factor binding protein-2 RNAs are expressed in adjacent tissues within rat embryonic and fetal limbs

1992 • 68 citations

Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of gf-4 and shh in the limb bud

1995 • 67 citations

The chicken limb deformity gene encodes nuclear proteins expressed in specific cell types during morphogenesis.

1992 • 63 citations

FGF-4 regulates expression of Evx-1 in the developing mouse limb

1993 • 63 citations

Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci.

1990 • 58 citations

A variant limb deformity transcript expressed in the embryonic mouse limb defines a novel formin.

1992 • 47 citations

IGF-I, insulin and FGFs induce outgrowth of the limb buds of amelic mutant chick embryos

1996 • 37 citations

The mouse mutant limb-deformity (ld).

1982 • 35 citations

Coordinate expression of IGF‐I and its receptor during limb outgrowth

1992 • 25 citations