Lipoxygenase inhibitors as potential cancer chemopreventives.

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

A rapid in vitro assay for quantitating the invasive potential of tumor cells.

1987 • 1,787 citations

Leukotrienes and Other Products of the 5-Lipoxygenase Pathway

1990 • 1,216 citations

Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings

1987 • 1,036 citations

Multistage carcinogenesis in mouse skin

1992 • 647 citations

Altered eicosanoid levels in human colon cancer.

1993 • 571 citations

Mammalian lipoxygenases: molecular structures and functions

1992 • 571 citations

Aberrant crypts: putative preneoplastic foci in human colonic mucosa.

1991 • 448 citations

5-lipoxygenase inhibitory activity of zileuton.

1991 • 409 citations

Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review.

1990 • 402 citations

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.

1993 • 397 citations

Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.

1992 • 382 citations

<italic>N</italic>-Nitrosomethylurea as Mammary Gland Carcinogen in Rats

1975 • 354 citations

The development of prostatic adenocarcinoma in Nb rats following prolonged sex hormone administration.

1977 • 350 citations

Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.

1996 • 341 citations

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

1989 • 337 citations

Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187.

1988 • 323 citations

The Anti-inflammatory Activity of Scutellaria rivularis Extracts and Its Active Components, Baicalin, Baicalein and Wogonin

1996 • 298 citations

Leukotrienes and Airway Responses

1987 • 295 citations

Direct activation of purified protein kinase C by unsaturated fatty acids (oleate and arachidonate) in the absence of phospholipids and Ca²⁺

1985 • 293 citations

Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea.

1985 • 289 citations

The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice

1996 • 265 citations

Arachidonic Acid Stimulates Prostate Cancer Cell Growth: Critical Role of 5-Lipoxygenase

1997 • 262 citations

Excessive production of reactive oxygen metabolites by inflamed colon: Analysis by chemiluminescence probe

1992 • 260 citations

Effects of fatty acids and inhibitors of eicosanoid synthesis on the growth of a human breast cancer cell line in culture.

1990 • 260 citations

Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen

1997 • 259 citations

On the nature of the 5-lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors.

1985 • 254 citations

Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling.

1996 • 252 citations

2,3,5-Trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-l,4-benzoquinone (AA861), a selective inhibitor of the 5-lipoxygenase reaction and the biosynthesis of slow-reacting substance of anaphylaxis

1982 • 251 citations

Selective inhibition of platelet lipoxygenase by baicalein

1982 • 245 citations

Relationship between dietary fat and experimental mammary tumorigenesis: a review and critique.

1992 • 232 citations

Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.

1994 • 231 citations

Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid

1986 • 229 citations

Effects of Dietary Omega-3 Fatty Acids on Human Breast Cancer Growth and Metastases in Nude Mice

1993 • 224 citations

Use of azoxymethane-induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents

1994 • 221 citations

Tumor Promotion by Dietary Fat in Azoxymethane-Induced Colon Carcinogenesis in Female F344 Rats: Influence of Amount and Source of Dietary Fat<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1984 • 220 citations

Arachidonate 5-lipoxygenase of guinea pig peritoneal polymorphonuclear leukocytes. Activation by adenosine 5'-triphosphate.

1983 • 215 citations

Effects of fatty acids and eicosanoid synthesis inhibitors on the growth of two human prostate cancer cell lines

1991 • 204 citations

12-Lipoxygenases and 12(S)-HETE: role in cancer metastasis

1994 • 202 citations

Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents

1998 • 200 citations

Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis

1983 • 199 citations

Dietary fat and mammary cancer.

1968 • 197 citations

5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation.

1995 • 192 citations

Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.

1990 • 189 citations

Biochemical Alterations in Sex Hormone-Induced Hyperplasia and Dysplasia of the Dorsolateral Prostates of Noble Rats

1988 • 187 citations

Dietary n‐3 (ω‐3) polyunsaturated fatty acid effects on animal tumorigenesis

1991 • 184 citations

Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer

1995 • 184 citations

Redistribution of 5-Lipoxygenase and Cytosolic Phospholipase A2 to the Nuclear Fraction upon Macrophage Activation

1993 • 181 citations

Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines

1994 • 181 citations

Epidermal growth factor activates calcium channels by phospholipase A25-lipoxygenase-mediated leukotriene C4 production

1992 • 179 citations

Selective inhibition of platelet lipoxygenase by esculetin

1982 • 177 citations

Preclinical efficacy evaluation of potential chemopreventive agents in animal carcinogenesis models: Methods and results from the NCI chemoprevention drug development program

1994 • 172 citations

Arachidonic acid 15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes. Partial purification and properties.

1981 • 165 citations

The epidermal growth factor receptor as a prognostic marker: Results of 370 patients and review of 3009 patients

1994 • 161 citations

Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-α-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain

1995 • 160 citations

The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo

1995 • 159 citations

Leukotrienes B4, C4 and D4 stimulate DNA synthesis in cultured human epidermal keratinocytes

1985 • 157 citations

The Preclinical Pharmacology of ICI 204,219: A Peptide Leukotriene Antagonist

1990 • 155 citations

Prostanoid and leukotriene receptors: a progress report from the IUPHAR working parties on classification and nomenclature.

1995 • 150 citations

Deficiency of Platelet Lipoxygenase Activity in Myeloproliferative Disorders

1982 • 149 citations

Dietary Fat and Mammary Cancer. I. Promoting Effects of Different Dietary Fats on <italic>N</italic>-Nitrosomethylurea-Induced Rat Mammary Tumorigenesis<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref><xref ref-type="fn" rid="FN3">4</xref>

1986 • 145 citations

Lifetime dose-response relationships for mammary tumor induction by a single administration of N-methyl-N-nitrosourea.

1981 • 145 citations

Role of fatty acids in signal transduction: Modulators and messengers

1993 • 144 citations

Tyrosine Kinase Activity Modulates Catalysis and Translocation of Cellular 5-Lipoxygenase

1996 • 140 citations

Arachidonic acid metabolism in benign and malignant prostatic tissue in vitro: Effects of fatty acids and cyclooxygenase inhibitors

1994 • 140 citations

Modulation of fibroblast proliferation by sulfidopeptide leukotrienes: effect of indomethacin.

1987 • 135 citations

Translocation and Leukotriene Synthetic Capacity of Nuclear 5-Lipoxygenase in Rat Basophilic Leukemia Cells and Alveolar Macrophages

1995 • 133 citations

Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.

1994 • 131 citations

The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells

1996 • 131 citations

Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice.

1997 • 130 citations

Modulators of Leukotriene Biosynthesis and Receptor Activation

1996 • 129 citations

Inhibition of Leukotriene D₄-induced Bronchoconstriction in Normal Subjects by the Oral LTD₄Receptor Antagonist ICI 204,219

1990 • 127 citations

Growth factors and their receptors as determinants in the proliferation and metastasis of human prostate cancer

1993 • 123 citations

Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells.

1991 • 122 citations

Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C.

1991 • 121 citations

Effects of D,L-2-difluoromethylornithine and indomethacin on mammary tumor promotion in rats fed high n-3 and/or n-6 fat diets.

1989 • 120 citations

Growth factors and oncogenes in prostate cancer.

1990 • 115 citations

Molecular cloning of a 12‐lipoxygenase cDNA from rat brain

1993 • 115 citations

Cell Death Induced by Baicalein in Human Hepatocellular Carcinoma Cell Lines

1996 • 113 citations

Comparison of the tumor-initiating activity of 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene in female SENCAR and CD-1 mice

1980 • 113 citations

Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)-indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor

1992 • 112 citations

12(S)-HETE Enhancement of Prostate Tumor Cell Invasion: Selective Role of PKC

1994 • 109 citations

Barrett's esophagus: metaplastic cells with loss of heterozygosity at the APC gene locus are clonal precursors to invasive adenocarcinoma.

1996 • 108 citations

Lipoxygenase Inhibitors Prevent Lung Carcinogenesis and Inhibit Non-Small Cell Lung Cancer Growth

1998 • 107 citations

Cloning of a phospholipase A2-activating protein.

1991 • 107 citations

Arachidonate 12-lipoxygenases

1997 • 106 citations

Leukotriene B4 enhances activation, proliferation, and differentiation of human B lymphocytes.

1989 • 106 citations

Two immunologically and catalytically distinct arachidonate 12-lipoxygenases of bovine platelets and leukocytes

1988 • 105 citations

A Lipoxygenase Metabolite, 12-(S)-HETE, Stimulates Protein Kinase C-Mediated Release of Cathepsin B from Malignant Cells

1994 • 105 citations

In vivo effects of indomethacin on the growth of murine mammary tumors.

1984 • 103 citations

Inhibition of the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid from arachidonic acid in polymorphonuclear leukocytes by various coumarins

1985 • 103 citations

Leukotriene C4 binds to human glomerular epithelial cells and promotes their proliferation in vitro.

1985 • 98 citations

Effects of linoleic acid on the growth and metastasis of two human breast cancer cell lines in nude mice and the invasive capacity of these cell lines in vitro.

1994 • 98 citations

The lipoxygenase metabolite 12(S)‐hete induces a cytoskeleton‐dependent increase in surface expression of integrin α_iibβ₃ on melanoma cells

1991 • 97 citations

The signal transduction system of the leukotriene D4 receptor

1989 • 96 citations

Eicosanoid synthesis in 7,12‐dimethylbenz(a)anthracene‐induced mammary carcinomas in Sprague‐Dawley rats fed primrose oil, menhaden oil or corn oil diet

1988 • 92 citations

Characterization of human 12-lipoxygenase genes.

1992 • 91 citations

<i>neu</i>(c-erbB-2/HER2) and the Epidermal Growth Factor Receptor (EGFR) in Breast Cancer

1993 • 88 citations

Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line

1996 • 88 citations

Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells

1996 • 86 citations

Mutagenesis of some conserved residues in human 5-lipoxygenase: effects on enzyme activity.

1992 • 86 citations

Induction of dorsolateral prostate adenocarcinomas and other accessory sex gland lesions in male Wistar rats by a single administration of N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl after sequential treatment with cyproterone acetate and testosterone propionate.

1990 • 85 citations

Essential fatty acid distribution in the plasma and tissue phospholipids of patients with benign and malignant prostatic disease

1991 • 84 citations

Arachidonic Acid Metabolites in bFGF-, PDGF-, and Serum-Stimulated Vascular Cell Growth

1994 • 83 citations

Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors

1992 • 83 citations

12‐lipoxygenase isoenzymes in mouse skin tumor development

1995 • 83 citations

Arachidonate 12-lipoxygenase of platelet-type in human epidermal cells

1993 • 83 citations

Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins

1991 • 80 citations

Interactions of 5-lipoxygenase with membranes: studies on the association of soluble enzyme with membranes and alterations in enzyme activity

1988 • 79 citations

Mode of action of the new selective leukotriene synthesis inhibitor BAY X 1005 {(R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid} and structurally related compounds

1993 • 78 citations

Inhibition of mammary carcinogenesis by flurbiprofen, a non-steroidal antiinflammatory agent

1983 • 77 citations

Investigation of the mechanism of non‐turnover‐dependent inactivation of purified human 5‐lipoxygenase

1992 • 77 citations

Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors.

1991 • 77 citations

Regulation of melanoma‐cell motility by the lipoxygenase metabolite 12‐(S)‐hete

1993 • 75 citations

Stimulation of growth of human breast cancer cell lines in culture by linoleic acid

1989 • 74 citations

Antiproliferative effects of lipoxygenase inhibitors on malignant human hematopoietic cell lines.

1989 • 71 citations

Lung Tumors in Strain A Mice as a Bioassay for Carcinogenicity of Environmental Chemicals

1991 • 70 citations

Anti-growth effects with components of Sho-saiko-to (TJ-9) on cultured human hepatoma cells

1993 • 68 citations

Chemoprevention of experimental carcinogenesis in animals

1989 • 68 citations

Epidermal Growth Factor Enhances a Microsomal 12 — Lipoxygenase Activity in A431 Cells

1993 • 67 citations

12(S)‐hete promotes tumor‐cell adhesion by increasing surface expression of α_Vβ₃ integrins on endothelial cells

1993 • 67 citations

Stimulation of human myelopoiesis by leukotrienes B4 and C4: interactions with granulocyte-macrophage colony-stimulating factor

1993 • 66 citations

Biosynthesis of 12(S)-hydroxyeicosatetraenoic acid by B16 amelanotic melanoma cells is a determinant of their metastatic potential.

1994 • 66 citations

Evidence for the role of leukotrienes C4 and D4 as essential intermediates in CSF-stimulated human myeloid colony formation.

1986 • 66 citations

Lipoxygenase inhibitors suppress formation of tumor necrosis factor in, vitro and in, vivo

1989 • 64 citations

Inhibition of tumour growth by lipoxygenase inhibitors

1996 • 63 citations

Increased 12-Lipoxygenase Expression in Breast Cancer Tissues and Cells. Regulation by Epidermal Growth Factor1

1997 • 63 citations

12‐Lipoxygenase, 12(S)‐HETE, and Cancer Metastasis^a

1994 • 61 citations

Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells.

1993 • 61 citations

Calcium Induces Membrane Translocation of 12-Lipoxygenase in Rat Platelets

1989 • 60 citations

Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase.

1991 • 59 citations

Characteristics of formation and further metabolism of leukotrienes in the chopped human lung

1990 • 59 citations

Demonstration of a 12-lipoxygenase activity in bovine polymorphonuclear leukocytes

1987 • 59 citations

Cysteinyl leukotrienes enhance growth of human airway epithelial cells

1990 • 59 citations

Characterization of a 15-Lipoxygenase in Human Breast Carcinoma BT-20 Cells: Stimulation of 13-HODE Formation by TGFα/EGF

1997 • 59 citations

Inhibition of growth and linoleate-enhanced metastasis of a transplantable mouse mammary tumor by indomethacin

1988 • 59 citations

Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells

1994 • 58 citations

Selective inhibitors of 5-lipoxygenase reduce CML blast cell proliferation and induce limited differentiation and apoptosis

1995 • 56 citations

Antiproliferative effect of esculetin on vascular smooth muscle cells: possible roles of signal transduction pathways

1993 • 55 citations

Activity and protein distribution of 12-lipoxygenase in HEL cells: Induction of membrane-association by phorbol ester TPA, modulation of activity by glutathione and 13-HPODE, and Ca2+-dependent translocation to membranes

1993 • 55 citations

Arachidonate 5-lipoxygenase inhibitors show potent antiproliferative effects on human leukemia cell lines

1986 • 54 citations

Modulation of cellular phospholipid fatty acids and leukotriene B4 synthesis in the human intestinal cell (CaCo-2).

1992 • 53 citations

The effect of dietary fat on the rapid development of mammary tumors induced by 7,12-dimethylbenz(a)anthracene in SENCAR mice.

1992 • 53 citations

Prediction of Metastatic Potential by a New Grading System of Cell Motility: Validation in the Dunning R-3327 Prostatic Adenocarcinoma Model

1987 • 53 citations

7-[3-(4-Acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid: an orally active selective leukotriene B4 receptor antagonist

1989 • 53 citations

An in vivo inhibitor of 5-lipoxygenase, MK886, at micromolar concentration induces apoptosis in U937 and CML cells.

1996 • 52 citations

Effects of indomethacin on the growth of cultured mammary tumors

1984 • 51 citations

Arachidonate 12-lipoxygenase

1995 • 50 citations

Should We Treat Children with Idiopathic Short Stature?

1999 • 50 citations

Profiles of eicosanoid production by superficial and proliferative colonic epithelial cells and sub-epithelial colonic tissue

1986 • 49 citations

Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesisin vitro by flavonoid baicalein fromScutellaria baicalensis georgy roots

1993 • 48 citations

Inhibitory Effects of Nabumetone, a Cyclooxygenase‐2 Inhibitor, and Esculetin, a Lipoxygenase Inhibitor, on N‐Methyl‐N‐nitrosourea‐induced Mammary Carcinogenesis in Rats

1998 • 47 citations

[6] Arachidonic acid-15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes

1982 • 46 citations

Anti-inflammatory and peripheral analgesic activity of esculetin in vivo

1988 • 45 citations

In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis

1993 • 45 citations

PKC mediates 12(S)‐HETE‐induced cytoskeletal rearrangement in B16A melanoma cells

1993 • 45 citations

Preparation of (R)-(+)-N-[3-[5-[(4-Fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor.

1995 • 45 citations

Nordihydroguaiaretic acid suppression of rat mammary carcinogenesis induced by N-methyl-N-nitrosourea

1987 • 44 citations

Eicosanoids and linoleate-enhanced growth of mouse mammary tumor cells

1991 • 44 citations

Characterization of adenocarcinomas of the dorsolateral prostate induced in Wistar rats by N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl, following sequential treatment with cyproterone acetate and testosterone propionate.

1990 • 44 citations

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects

1986 • 43 citations

Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers

1997 • 43 citations

Modulation of colony stimulating factor-induced murine myeloid colony formation by S-peptido-lipoxygenase products.

1986 • 41 citations

SC-41930: An inhibitor of leukotriene B4-stimulated human neutrophil functions

1989 • 41 citations

Leukotriene B4 causes proliferation of interleukin 2-dependent T cells in the presence of suboptimal levels of interleukin 2

1986 • 41 citations

Lipoxygenase metabolites of arachidonic acid modulate hematopoiesis

1986 • 40 citations

BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics.

1993 • 39 citations

Effects of Eicosanoid Synthesis Inhibitors on the in vitro Growth and Prostaglandin E and Leukotriene B Secretion of a Human Breast Cancer Cell Line

1995 • 39 citations

Lipoxygenase products as common intermediates in cyclic AMP-dependent and -independent adrenal steroidogenesis in rats

1988 • 39 citations

Inhibition of 12-O-Tetradecanoylphorbol-13-Acetate-lnduced Increase in Vascular Permeability in Mouse Skin by Lipoxygenase Inhibitors

1985 • 38 citations

Multiple use of a signal transduction pathway in tumor cell invasion.

1996 • 36 citations

On the mechanism of induction of dna synthesis in cultured arterial smooth muscle cells by leukotrienes: Possible role of prostaglandin endoperoxide synthase products and platelet-derived growth factor

1991 • 36 citations

MK 886, an antagonist of leukotriene generation, inhibits DNA synthesis in a subset of acute myeloid leukaemia cells

1993 • 35 citations

Elevated white blood cell synthesis of leukotriene C₄ in chronic myelogenous leukaemia but not in polycythaemia vera

1990 • 35 citations

Effect of Zileuton (A-64077) on the 5-lipoxygenase activity of human whole bloodex vivo

1991 • 35 citations

Comparative Effects of Piroxicam and Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12-Dimethylbenz[a]anthracene in Rats on High- and Low-Fat Diets

1994 • 34 citations

Unsaturated fatty acid effects on human breast cancer cell adhesion

1995 • 34 citations

The effect of prostaglandin modulators on prostate tumor growth and metastasis.

1984 • 34 citations

Human PC‐3 prostate cell line DNA synthesis is suppressed by eicosatetraynoic acid, an in vitro inhibitor of arachidonic acid metabolism

1988 • 32 citations

Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis

1989 • 29 citations

The 12-lipoxygenase gene-transfected MCF-7 human breast cancer cell line exhibits estrogen-independent, but estrogen and omega-6 fatty acid-stimulated proliferation in vitro, and enhanced growth in athymic nude mice

1996 • 29 citations

Rat pulmonary lipoxygenase: dioxygenase activity and role in xenobiotic metabolism

1992 • 28 citations

Arachidonic acid-dependent activation of benzo[a]pyrene to bind to proteins with cytosolic and microsomal fractions from rat liver and lung

1984 • 27 citations

Eicosanoids in breast cancer patients before and after mastectomy

1992 • 27 citations

Inhibition of mouse epidermal 12-lipoxygenase by 2,3,4-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-l,4-benzoquinone (AA861)

1985 • 27 citations

Molecular evolution of cyclooxygenase and lipoxygenase

1992 • 26 citations

CD11c expression in B-cell chronic lymphocytic leukemia [letter]

1993 • 26 citations

A new class of leukotriene biosynthesis inhibitor: the development of MK-0591.

1993 • 26 citations

Direct observation of iron-induced conformational changes of mitochondrial DNA by high-resolution field-emission in-lens scanning electron microscopy.

1996 • 26 citations

Prostaglandin modulation of prostate tumor growth and metastases.

1986 • 26 citations

Overexpression of Ha-ras enhances the transcription of human arachidonate 12-lipoxygenase promoter in A431 cells

1997 • 25 citations

Biosynthesis of prostaglandins and hydroxy fatty acids in primary squamous carcinomas of head and neck in humans

1985 • 25 citations

The 5-lipoxygenase pathway in cultured human intestinal epithelial cells

1995 • 25 citations

Failure of Indomethacin To Inhibit Growth of the R3230AC Mammary Tumor in Rats<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>

1985 • 24 citations

Induction of apoptosis in blood cells from a patient with acute myelogenous leukemia by SC41661A, a selective inhibitor of 5-lipoxygenase

1993 • 24 citations

Cellular motility and prostatic carcinoma metastases

1993 • 23 citations

Induction of 12-Lipoxygenase Expression by Epidermal Growth Factor is Mediated by Protein Kinase C in A431 Cells

1997 • 22 citations

Arachidonic acid metabolism of cytosolic fractions of Lewis lung carcinoma cells.

1991 • 22 citations

Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: Implications for biological regulation of 5-lipoxygenase

1994 • 22 citations

A human epithelial cell line, intestine 407, can produce 5-hydroxyeicosatetraenoic acid and leukotriene B4

1993 • 21 citations

Epidermal growth factor enhances transcription of human arachidonate 12-lipoxygenase in A431 cells

1997 • 21 citations

Exercise‐induced Bronchoconstriction: Elucidating the Roles of Leukotrienes and Prostaglandins

1997 • 21 citations

Inhibition of leukotriene b4 formation in human neutrophils after oral nafazatrom (Bay g 6575)

1985 • 21 citations

Decreased messenger RNA of arachidonate 12-lipoxygenase in platelets of patients with myeloproliferative disorders

1993 • 19 citations

Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity

1994 • 19 citations

Influence of Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12‐Dimethylbenz[α]anthracene in Rats on High‐ and Low‐fat Diets

1993 • 17 citations

Second Generation Leukotriene B4 Receptor Antagonists Related to SC-41930: Heterocyclic Replacement of the Methyl Ketone Pharmacophore

1995 • 17 citations

Cell proliferation status, cytokine action and protein tyrosine phosphorylation modulate leukotriene biosynthesis in a basophil leukaemia and a mastocytoma cell line

1994 • 17 citations

Induction of cyclooxygenase and suppression of 12-lipoxygenase in human erythroleukemia cells upon phorbol ester-induced differentiation

1993 • 17 citations

Inhibition of arachidonic acid 5-lipoxygenase of human polymorphonuclear leukocytes by esculetin.

1984 • 16 citations

[34] Leukocyte arachidonate 5-lipoxygenase: Isolation and characterization

1990 • 16 citations

The selective 5-lipoxygenase inhibitor A63162 reduces PC3 proliferation and initiates morphologic changes consistent with secretion.

1994 • 16 citations

BAY X1005, a new selective inhibitor of leukotriene synthesis: pharmacology and pharmacokinetics.

1993 • 15 citations

Mechanisms of Inhibition of Tumor Progression

1993 • 15 citations

Nephrotic syndrome associated with N-hydroxyureas, inhibitors of 5-lipoxygenase

1995 • 14 citations

Inhibition of Adenylyl Cyclases by 12(S)-Hydroxyeicosatetraenoic Acid

1996 • 14 citations

Inhibitors of lipoxygenase have antiproliferative effects on P815 murine mastocytoma cells

1990 • 14 citations

Lipoxygenase inhibitors counteract protein kinase C mediated events in human T lymphocyte proliferation

1997 • 14 citations

The in vitro pharmacology of SC-51146: a potent antagonist of leukotriene B4 receptors.

1994 • 14 citations

Biological properties of 12(S)-HETE in cancer metastasis.

1995 • 13 citations

Interleukin-3 enhances the endogenous leukotriene production.

1993 • 13 citations

Dietary Fat and Breast Cancer: A Search for Mechanisms

1992 • 12 citations

5,8,11,14-Eicosatetraynoic acid-induced destruction of mitochondria in human prostate cells (PC-3)

1992 • 11 citations

Effects of lipoxygenase and cyclooxygenase inhibitors on the induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate and isoproterenol in mouse tissues in vivo

1986 • 11 citations

A-78773: a selective, potent 5-lipoxygenase inhibitor.

1993 • 9 citations

Eicosanoids in breast cancer

1987 • 8 citations

Morphologic changes of apoptosis induced in human chronic myelogenous leukemia "blast" cells by SC41661A (Searle), a selective inhibitor of 5-lipoxygenase.

1994 • 7 citations

Evaluation of 5-lipoxygenase inhibitors, zileuton, A-78773 and ICI-D-2138 in an ionophore (A-23187)-induced pleural inflammation model in the rat

1993 • 7 citations

Antiproliferative effects of lipoxygenase inhibitors on human leukemia cells.

1991 • 4 citations

The relationship between natural killer cells and drugs that modify metastasis of PA-III cells

1985 • 4 citations

A compendium of reviews in biochemistry and molecular biology published in the second half of 1993

1994 • 4 citations

THE DESIGN OF THERAPEUTICALLY EFFECTIVE 5-LIPOXYGENASE INHIBITORS

1995 • 3 citations