Cell proliferation status, cytokine action and protein tyrosine phosphorylation modulate leukotriene biosynthesis in a basophil leukaemia and a mastocytoma cell line

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1983 • 2,839 citations

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

1989 • 607 citations

Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid.

1992 • 546 citations

Identification and isolation of a membrane protein necessary for leukotriene production

1990 • 464 citations

Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937.

1990 • 428 citations

Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187.

1988 • 323 citations

Signal transduction of the human granulocyte-macrophage colony- stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins

1990 • 294 citations

Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes

1988 • 249 citations

Inflammation: Basic Principles and Clinical Correlates

1988 • 228 citations

Cloning of the cDNA for human 5-lipoxygenase.

1988 • 222 citations

Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists.

1990 • 213 citations

Tumour necrosis factor (cachectin) induces phospholipase A2 activity and synthesis of a phospholipase A2-activating protein in endothelial cells

1988 • 203 citations

The neutrophil-activating peptide NAF/NAP-1 induces histamine and leukotriene release by interleukin 3-primed basophils.

1989 • 186 citations

Leukotriene production in human neutrophils primed by recombinant human granulocyte/macrophage colony-stimulating factor and stimulated with the complement component C5A and FMLP as second signals.

1988 • 185 citations

Epidermal growth factor activates calcium channels by phospholipase A25-lipoxygenase-mediated leukotriene C4 production

1992 • 179 citations

Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A

1988 • 166 citations

Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro

1991 • 139 citations

The effect of interleukin 3 upon IgE‐dependent and IgE‐independent basophil degranulation and leukotriene generation

1991 • 120 citations

Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line

1991 • 105 citations

Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells.

1992 • 68 citations

A23187-induced translocation of 5-lipoxygenase in osteosarcoma cells.

1992 • 65 citations

Studies on the Regulation, Biosynthesis, and Activation of 5-Lipoxygenase in Differentiated HL60 Cells

1989 • 60 citations

Evidence for coordinate, selective regulation of eicosanoid synthesis in platelet-derived growth factor-stimulated 3T3 fibroblasts and in HL-60 cells induced to differentiate into macrophages or neutrophils.

1988 • 57 citations

Antigen- and ionophore-induced signal transduction in rat basophilic leukemia cells involves protein tyrosine phosphorylation.

1991 • 57 citations

Leukotriene B4 stimulates c-fos and c-jun gene transcription and AP-1 binding activity in human monocytes

1992 • 55 citations

Translocation of phospholipase A2 from cytosol to membranes induced by 1-oleoyl-2-acetyl-glycerol in serum-free cultured macrophages

1987 • 42 citations

Protein kinase C plays an inhibitory role in interleukin 3- and interleukin 4-mediated mast cell proliferation.

1990 • 40 citations

Interleukin 8-inhibitor and inducer of histamine and leukotriene release in human basophils

1991 • 33 citations

Early reversible induction of leukotriene synthesis in chicken myelomonocytic cells transformed by a temperature-sensitive mutant of avian leukemia virus E26.

1989 • 32 citations

Chemotactic peptide stimulated endogenous arachidonic acid metabolism in HL60 granulocytes

1981 • 29 citations

Cloned mouse mast cells derived from immunized lymph node cells and from foetal liver cells exhibit characteristics of bone marrow-derived mast cells containing chondroitin sulphate E proteoglycan.

1984 • 27 citations

Uptake, production and metabolism of cysteinyl leukotrienes in the isolated perfused rat liver. Inhibition of leukotriene uptake by cyclosporine

1989 • 26 citations

Calcium ionophore and chemotactic peptide stimulation of peptidoleukotriene synthesis in DMSO-differentiated HL60 cells

1986 • 24 citations

Transient activation of topoisomerase I in leukotriene D4 signal transduction in human cells

1990 • 24 citations

The sensitized liver represents a rich source of endogenous leukotrienes

1991 • 20 citations

Ionophore-stimulated lipoxygenase activity and histamine release in a cloned murine mast cell, MC9

1985 • 19 citations

Formation and effects of leukotriene B4 in human lymphocytes.

1989 • 16 citations

Pertussis toxin pretreatment reveals differential effects of adenosine analogs on IgE-dependent histamine and peptidoleukotriene release from RBL-2H3 cells

1990 • 14 citations