Tyrosine Kinase Activity Modulates Catalysis and Translocation of Cellular 5-Lipoxygenase

Protein modules and signalling networks

1995 • 2,447 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

Leukotrienes and Other Products of the 5-Lipoxygenase Pathway

1990 • 1,216 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations

1991 • 1,036 citations

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

1990 • 777 citations

Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase

1991 • 491 citations

Identification and isolation of a membrane protein necessary for leukotriene production

1990 • 464 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

[30] Use and specificity of genistein as inhibitor of protein-tyrosine kinases

1991 • 421 citations

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.

1993 • 397 citations

Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187.

1988 • 323 citations

MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.

1990 • 319 citations

Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.

1984 • 292 citations

On the nature of the 5-lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors.

1985 • 254 citations

Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, from Streptomyces griseolavendus

1989 • 249 citations

[31] Use and selectivity of herbimycin A as inhibitor of protein-tyrosine kinases

1991 • 218 citations

5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation.

1995 • 192 citations

Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.

1990 • 189 citations

Redistribution of 5-Lipoxygenase and Cytosolic Phospholipase A2 to the Nuclear Fraction upon Macrophage Activation

1993 • 181 citations

Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells.

1994 • 153 citations

Cytoplasmic phospholipase A2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein kinase.

1994 • 149 citations

Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro

1991 • 139 citations

Inhibition of epidermal growth factor‐induced DNA synthesis by tyrosine kinase inhibitors

1990 • 132 citations

5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins.

1994 • 119 citations

cDNA Cloning, Expression, Mutagenesis, Intracellular Localization, and Gene Chromosomal Assignment of Mouse 5-Lipoxygenase

1995 • 107 citations

Regulation of eicosanoid biosynthesis in the macrophage

1993 • 100 citations

Reversible translocation of 5-lipoxygenase in mast cells upon IgE/antigen stimulation.

1993 • 97 citations

Tyrosine phosphorylation in activated human neutrophils. Comparison of the effects of different classes of agonists and identification of the signaling pathways involved.

1994 • 94 citations

Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by Lavendustin-A and its analogue.

1991 • 81 citations

Membrane association of active 5-lipoxygenase in resting cells. Evidence for novel regulation of the enzyme in the rat alveolar macrophage.

1992 • 81 citations

Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors.

1991 • 77 citations

[29] Inhibition of protein-tyrosine kinases by tyrphostins

1991 • 76 citations

Influx of extracellular calcium is required for the membrane translocation of 5-lipoxygenase and leukotriene synthesis

1991 • 72 citations

Granulocyte-macrophage colony-stimulating factor-induced protein tyrosine phosphorylation of microtubule-associated protein kinase in human neutrophils.

1992 • 66 citations

A23187-induced translocation of 5-lipoxygenase in osteosarcoma cells.

1992 • 65 citations

Studies on the Regulation, Biosynthesis, and Activation of 5-Lipoxygenase in Differentiated HL60 Cells

1989 • 60 citations

Tyrosine phosphorylation and activation of Vav GTP/GDP exchange activity in antigen receptor-triggered B cells.

1994 • 57 citations

Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors.

1991 • 49 citations

Stimulation of leukotriene production and membrane translocation of 5-lipoxygenase by cross-linking of the IgE receptors in RBL-2H3 cells

1992 • 43 citations

Irreversible inactivation of 5-lipoxygenase by leukotriene A4. Characterization of product inactivation with purified enzyme and intact leukocytes.

1994 • 43 citations

Criteria for the identification of non-redox inhibitors of 5-lipoxygenase

1993 • 42 citations

Characterization of a 5-lipoxygenase-activating protein binding assay: correlation of affinity for 5-lipoxygenase-activating protein with leukotriene synthesis inhibition.

1992 • 39 citations

Regulation of phospholipase A2 in human leukemia cell lines: its implication for intracellular signaling.

1994 • 31 citations

.alpha.-Secondary isotope effects in the lipoxygenase reaction

1989 • 29 citations

Interaction between Chemoattractants and Bacterial Lipopolysaccharide in the Induction and Enhancement of Neutrophil Adhesion

1990 • 25 citations