The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice

Beyond Cholesterol

1989 • 6,533 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1983 • 2,839 citations

Book ReviewAmbulatory Pediatric Care

1989 • 2,075 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

1995 • 1,133 citations

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

1995 • 1,102 citations

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II

1995 • 985 citations

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1994 • 850 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

1995 • 700 citations

Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases

1976 • 638 citations

Mammalian lipoxygenases: molecular structures and functions

1992 • 571 citations

The Three-Dimensional Structure of an Arachidonic Acid 15-Lipoxygenase

1993 • 460 citations

Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene

1994 • 428 citations

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.

1993 • 397 citations

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

1991 • 386 citations

5-LIPOXYGENASE

1994 • 357 citations

Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody.

1994 • 352 citations

Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187.

1988 • 323 citations

Nonimmunological Production pf Leukotrienes Induced by Platelet-Activating Factor

1982 • 305 citations

Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification

1988 • 301 citations

The Lipoxygenase of Reticulocytes

1979 • 280 citations

Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region.

1994 • 267 citations

Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils.

1979 • 258 citations

Pulmonary responses to bronchoconstrictor agonists in the mouse

1988 • 251 citations

Disruption of 12/15-Lipoxygenase Expression in Peritoneal Macrophages

1996 • 249 citations

Primary structure of soybean lipoxygenase L-2.

1988 • 238 citations

Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.

1994 • 231 citations

5‐lipoxygenase‐activating protein is an arachidonate binding protein

1993 • 230 citations

cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases.

1994 • 226 citations

Altering Genes in Animals by Gene Targeting

1992 • 224 citations

Arachidonate 5-lipoxygenase of guinea pig peritoneal polymorphonuclear leukocytes. Activation by adenosine 5'-triphosphate.

1983 • 215 citations

Molecular cloning and primary structure of human 15-lipoxygenase

1988 • 214 citations

12-Lipoxygenases and 12(S)-HETE: role in cancer metastasis

1994 • 202 citations

Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins.

1993 • 196 citations

5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation.

1995 • 192 citations

Enzymes involved in the biosynthesis of leukotriene B4

1989 • 191 citations

Altered inflammatory responses in leukotriene-deficient mice.

1994 • 186 citations

Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis.

1996 • 182 citations

Redistribution of 5-Lipoxygenase and Cytosolic Phospholipase A2 to the Nuclear Fraction upon Macrophage Activation

1993 • 181 citations

Arachidonate 12-lipoxygenase purified from porcine leukocytes by immunoaffinity chromatography and its reactivity with hydroperoxyeicosatetraenoic acids.

1986 • 168 citations

5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of human eosinophil migration.

1995 • 161 citations

Primary structure of soybean lipoxygenase-1.

1987 • 155 citations

Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells.

1994 • 153 citations

Deficiency of Platelet Lipoxygenase Activity in Myeloproliferative Disorders

1982 • 149 citations

Tyrosine Kinase Activity Modulates Catalysis and Translocation of Cellular 5-Lipoxygenase

1996 • 140 citations

“Enzymatic” lipid peroxidation: Reactions of mammalian lipoxygenases

1991 • 137 citations

Crystalline Lipoxidase.

1947 • 134 citations

Translocation and Leukotriene Synthetic Capacity of Nuclear 5-Lipoxygenase in Rat Basophilic Leukemia Cells and Alveolar Macrophages

1995 • 133 citations

Isolation and characterization of a cDNA clone encoding rat 5-lipoxygenase.

1988 • 132 citations

Specific action of the lipoxygenase pathway in mediating angiotensin II-induced aldosterone synthesis in isolated adrenal glomerulosa cells.

1987 • 130 citations

5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins.

1994 • 119 citations

Molecular cloning of a 12‐lipoxygenase cDNA from rat brain

1993 • 115 citations

Identification of 15–hydroxy‐5,8,11,13–eicosatetraenoic acid (15–HETE) as a major metabolite of arachidonic acid in human lung

1980 • 112 citations

Enhanced Levels of Lipoperoxides in Low Density Lipoprotein Incubated with Murine Fibroblasts Expressing High Levels of Human 15-Lipoxygenase

1995 • 107 citations

cDNA Cloning, Expression, Mutagenesis, Intracellular Localization, and Gene Chromosomal Assignment of Mouse 5-Lipoxygenase

1995 • 107 citations

Two immunologically and catalytically distinct arachidonate 12-lipoxygenases of bovine platelets and leukocytes

1988 • 105 citations

Leukotriene B4 in the immune system

1992 • 103 citations

The complete sequence of the rabbit erythroid cell-specific 15-lipoxygenase mRNA: comparison of the predicted amino acid sequence of the erythrocyte lipoxygenase with other lipoxygenases

1989 • 103 citations

Functional Expression and Cellular Localization of a Mouse Epidermal Lipoxygenase

1996 • 101 citations

Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells.

1990 • 100 citations

Molecular Biology in the Eicosanoid Field

1993 • 96 citations

Lipoxygenases: Structural Principles and Spectroscopy

1996 • 93 citations

Structure conservation in lipoxygenases: Structural analysis of soybean lipoxygenase-1 and modeling of human lipoxygenases

1996 • 91 citations

Arachidonate 12-lipoxygenase of platelet-type in human epidermal cells

1993 • 83 citations

Interactions of 5-lipoxygenase with membranes: studies on the association of soluble enzyme with membranes and alterations in enzyme activity

1988 • 79 citations

The structure and function of lipoxygenase

1994 • 75 citations

Induction of 15-Lipoxygenase mRNA and Protein in Early Atherosclerotic Lesions

1995 • 73 citations

Regulation of 5-lipoxygenase and 5-lipoxygenase-activating protein expression in HL-60 cells

1993 • 73 citations

Arachidonate 15-lipoxygenase; characteristics and potential biological significance.

1991 • 72 citations

Identification of a novel arachidonate 12-lipoxygenase in bovine tracheal epithelial cells distinct from leukocyte and platelet forms of the enzyme.

1990 • 70 citations

Arachidonate 12-lipoxygenase is localized in neurons, glial cells, and endothelial cells of the canine brain.

1993 • 68 citations

The mechanism of leukotriene B4 export from human polymorphonuclear leukocytes.

1990 • 66 citations

Molecular cloning and expression of human arachidonate 12-lipoxygenase

1990 • 65 citations

Stimulation of human myelopoiesis by leukotriene B 4

1985 • 64 citations

Generation of the arachidonic acid metabolite 8-HETE by extracts of mouse skin treated with phorbol ester in vivo; identification by ¹H-n.m.r. and GC-MS spectroscopy

1986 • 62 citations

Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells.

1993 • 61 citations

Arachidonate 15-hpoxygenase

1995 • 61 citations

Calcium Induces Membrane Translocation of 12-Lipoxygenase in Rat Platelets

1989 • 60 citations

Demonstration of a 12-lipoxygenase activity in bovine polymorphonuclear leukocytes

1987 • 59 citations

Studies on porcine arachidonate 12-lipoxygenase using its monoclonal antibodies.

1986 • 57 citations

Activity and protein distribution of 12-lipoxygenase in HEL cells: Induction of membrane-association by phorbol ester TPA, modulation of activity by glutathione and 13-HPODE, and Ca2+-dependent translocation to membranes

1993 • 55 citations

Evidence that a leukocyte type of 12-lipoxygenase is expressed and regulated by angiotensin II in human adrenal glomerulosa cells.

1994 • 55 citations

Cloning and characterization of a murine macrophage lipoxygenase

1995 • 53 citations

A cryptic, microsomal-type arachidonate 12-lipoxygenase is tonically inactivated by oxidation-reduction conditions in cultured epithelial cells.

1993 • 53 citations

Localization of Arachidonate 12‐Lipoxygenase in Canine Brain Tissues

1992 • 52 citations

Effects on Glucose-induced Insulin Secretion of Lipoxygenase-derived Metabolites of Arachidonic Acid

1984 • 51 citations

Arachidonate 12-lipoxygenase of rat pineal glands: Catalytic properties and primary structure deduced from its cDNA

1994 • 50 citations

Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.

1992 • 49 citations

The transcriptional regulation of human arachidonate 12‐lipoxygenase gene by NFκB/Rel

1995 • 48 citations

The promoter structure and complete sequence of the gene encoding the rabbit erythroid cell-specific 15-lipoxygenase

1989 • 47 citations

Scoring a Technical Knockout in Mice

1992 • 43 citations

Regio- and stereochemistry of the dioxygenation reaction catalyzed by (S)-type lipoxygenases or by the cyclooxygenase activity of prostaglandin H synthases

1994 • 42 citations

Ribozyme-Mediated Inhibition of Expression of Leukocyte-type 12-Lipoxygenase in Porcine Aortic Vascular Smooth Muscle Cells

1995 • 42 citations

Modulation of colony stimulating factor-induced murine myeloid colony formation by S-peptido-lipoxygenase products.

1986 • 41 citations

Calcium promotes membrane association of reticulocyte 15-lipoxygenase

1994 • 39 citations

Molecular structure and function of the porcine arachidonate 12-lipoxygenase gene.

1992 • 36 citations

12-Lipoxygenase in Lewis lung carcinoma cells: Molecular identity, intracellular distribution of activity and protein, and Ca2+-dependent translocation from cytosol to membranes

1995 • 29 citations

Cloning of the guinea pig 5-lipoxygenase gene and nucleotide sequence of its promoter

1992 • 29 citations

Genomic and cDNA cloning of a novel mouse lipoxygenase gene

1995 • 28 citations

Prostaglandin H Synthase and Lipoxygenase Gene Families in the Epithelial Cell Barrier^a

1994 • 28 citations

Tissue-specific regulation of the rabbit 15-lipoxygenase gene in erythroid cells by a transcriptional silencer

1995 • 24 citations

Augmentation of human natural cytotoxic cell activity by leukotriene B4 mediated by enhanced effector-target cell binding and increased lytic efficiency

1987 • 23 citations

15-Hydroxyeicosatetraenoic acid (15-HETE) receptors. Involvement in the 15-HETE-induced stimulation of the cryptic 5-lipoxygenase in PT-18 mast/basophil cells.

1992 • 21 citations

Decreased messenger RNA of arachidonate 12-lipoxygenase in platelets of patients with myeloproliferative disorders

1993 • 19 citations

A possible role for 15-lipoxygenase in atherogenesis

1995 • 16 citations

Subcellular localization of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid binding sites in Lewis lung carcinoma cells

1995 • 13 citations

Lipoxygenase Deficiency in Primary Thrombocythemia Is not a True Deficiency

1994 • 12 citations

Fibronectin-Induced Cell Spreading and Down-Regulation of 12-Lipoxygenase Expression in Megakaryocytic DAMI Cells

1994 • 8 citations

Targeted Gene Disruption by Homologous Recombination

1994 • 8 citations