Arachidonic acid 15-lipoxygenase from rabbit peritoneal polymorphonuclear leukocytes. Partial purification and properties.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

The gel-filtration behaviour of proteins related to their molecular weights over a wide range

1965 • 3,062 citations

The pharmacological basis of therapeutics

1981 • 2,853 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Prostaglandins and Thromboxanes

1978 • 1,310 citations

Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

1979 • 992 citations

Prostaglandins, Aspirin-like Drugs and Analgesia

1972 • 871 citations

On the Specificity of the Oxygenation of Unsaturated Fatty Acids Catalyzed by Soybean Lipoxidase

1967 • 660 citations

Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.

1979 • 652 citations

Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases

1976 • 638 citations

Arachidonate lipoxygenase in blood platelets

1975 • 613 citations

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

1976 • 606 citations

Human leukocyte granule elastase: rapid isolation and characterization

1976 • 550 citations

A new approach to anti-inflammatory drugs

1979 • 501 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids.

1979 • 465 citations

Chemokinetic activity of arachidonic acid lipoxygenase products on leuocyctes of different species

1980 • 399 citations

Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets

1975 • 393 citations

Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid.

1980 • 330 citations

Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes

1978 • 306 citations

Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils.

1979 • 258 citations

Prostaglandin endoperoxides VII. Novel transformations of arachidonic acid in guinea pig lung

1974 • 226 citations

15-hydroxy-5,8,11,13-eicosatetraenoic acid: A potent and selective inhibitor of platelet lipoxygenase.

1980 • 195 citations

Calcium stimulation of a novel lipoxygenase

1980 • 179 citations

Superoxide production induced in rabbit polymorphonuclear leukocytes by synthetic chemotactic peptides and A23187.

1979 • 158 citations

Homolytic decomposition of linoleic acid hydroperoxide: Identification of fatty acid products

1974 • 156 citations

Decomposition of unsaturated fatty acid hydroperoxides by hemoglobin: Structures of major products of 13L‐hydroperoxy‐9,11‐octadecadienoic acid

1975 • 154 citations

Iron, an Essential Component of Lipoxygenase

1974 • 151 citations

The autoxidation of arachidonic acid: Formation of the proposed SRS-A intermediate

1979 • 140 citations

Enzymatic assembly of slow reacting substance

1980 • 122 citations

Inhibition of arachidonic acid cyclo-oxygenase and lipoxygenase activities of leukocytes by indomethacin and compound BW755C

1980 • 121 citations

The production of the arachidonate metabolite HETE in vascular tissue

1979 • 115 citations

Prostaglandin Synthetase System—Resolution into Oxygenase and Isomerase Components

1974 • 112 citations

Aspirin-like drugs inhibit arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenan pleural exudates

1980 • 109 citations

Soya-bean lipoxygenase: An iron-containing dioxygenase

1973 • 102 citations

The identification of trihydroxyeicosatrienoic acids as products from the incubation of arachidonic acid with washed blood platelets

1978 • 99 citations

Identification of a component of rat mononuclear cell SRS as leukotriene D

1980 • 90 citations

Soyabean lipoxygenase: An iron-containing enzyme

1973 • 80 citations

Human thymidylate synthetase derived from blast cells of patients with acture myelocytic leukemia. Purification and chracterization.

1977 • 79 citations

The inhibitory effects of BW 755C on arachidonic acid metabolism in human polymorphonuclear leukocytes

1980 • 79 citations

The mechanism of enhancement by fatty acid hydroperoxides of anaphylactic mediator release

1978 • 67 citations

Stimulation of the oxidative metabolism of polymorphonuclear leucocytes by the calcium ionophore A23187

1974 • 67 citations

The identification of an epoxy-hydroxy acid as a product from the incubation of arachidonic acid with washed blood platelets

1979 • 59 citations

Exocytosis in human polymorphonuclear leukocytes induced by A 23187 and calcium

1975 • 50 citations

Isolation of human leukocyte granules using colloidal silica-polysaccharide density gradients

1969 • 35 citations

Simple synthesis of the 11,12-oxido and 14,15-oxido analogs of leukotriene A and the corresponding conjugates with glutathione and cysteinylglycine, analogs of leukotrienes C and D

1980 • 34 citations