Effects of Metals on Gene Expression

Advanced inorganic chemistry

1999 • 14,227 citations

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Environmental Health Criteria

1980 • 3,867 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

The biochemical basis of zinc physiology

1993 • 2,967 citations

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.

1985 • 2,450 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

METALLOTHIONEIN

1986 • 1,606 citations

TRANSCRIPTION FACTORS: Structural Families and Principles of DNA Recognition

1992 • 1,411 citations

Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper–transporting ATPase

1993 • 1,395 citations

Biochemistry of metallothionein

1988 • 1,222 citations

Toxic effects of metals

1991 • 1,198 citations

A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture

1980 • 1,180 citations

Advanced Inorganic Chemistry: A Comprehensive Text

1972 • 1,136 citations

Casarett and Doull's toxicology

2015 • 1,127 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Environmental Health Criteria 75

1989 • 1,024 citations

The importance of free radicals and catalytic metal ions in human diseases

1985 • 939 citations

Oxygen free radicals and metallothionein

1993 • 848 citations

Mechanism of Action of the Female Sex Hormones

1972 • 763 citations

Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein

1993 • 720 citations

Isolation of a partial candidate gene for Menkes disease by positional cloning

1993 • 690 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site

1983 • 667 citations

Transition Metals in Control of Gene Expression

1993 • 629 citations

Overexpression of Metallothionein Confers Resistance to Anticancer Drugs

1988 • 600 citations

Selenium in Biology and Medicine

1989 • 586 citations

Identification of the Iron-Responsive Element for the Translational Regulation of Human Ferritin mRNA

1987 • 547 citations

The common 90-kd protein component of non-transformed ‘8S’ steroid receptors is a heat-shock protein.

1985 • 527 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein.

1985 • 492 citations

Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement

1987 • 428 citations

Higher order metaphase chromosome structure: Evidence for metalloprotein interactions

1982 • 398 citations

Role of Nucleosomal Cores and Histone H1 in Regulation of Transcription by RNA Polymerase II

1991 • 379 citations

Binding of a Cytosolic Protein to the Iron-Responsive Element of Human Ferritin Messenger RNA

1988 • 363 citations

Metal carcinogenesis: Mechanistic implications

1992 • 348 citations

SPECIFIC NUCLEAR TRIIODOTHYRONINE BINDING SITES IN RAT LIVER AND KIDNEY¹

1972 • 336 citations

Metal Ions in Biological Systems

1989 • 336 citations

In vivo protein–DNA interactions in a glucocorticoid response element require the presence of the hormone

1986 • 328 citations

Cis-Trans Models for Post-Transcriptional Gene Regulation

1989 • 322 citations

Human heme oxygenase cDNA and induction of its mRNA by hemin

1988 • 320 citations

Yeast HAP1 activator binds to two upstream activation sites of different sequence

1987 • 317 citations

Functional dissection and sequence of yeast HAP1 activator

1989 • 309 citations

Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity

1989 • 308 citations

Role of chromatin structure in the regulation of transcription by RNA polymerase II

1993 • 298 citations

Metal-regulated transcription in eukaryotes

1992 • 297 citations

Assignment of the gene for Wilson disease to chromosome 13: linkage to the esterase D locus.

1985 • 282 citations

Regulation by Heme of Mitochondrial Protein Transport Through a Conserved Amino Acid Motif

1993 • 279 citations

Activation in vitro of sequence-specific DNA binding by a human regulatory factor

1988 • 278 citations

Chromatin Structure and Transcription

1992 • 259 citations

Metallothionein protects DNA from oxidative damage

1993 • 254 citations

Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Spl

1991 • 252 citations

Signal transduction from cell surface to nucleus in development and disease

1992 • 246 citations

Yeast HAP1 activator competes with the factor RC2 for binding to the upstream activation site UAS1 of the CYC1 gene

1987 • 245 citations

Molecular Biology of Selenoproteins

1990 • 233 citations

Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase.

1993 • 230 citations

Transcriptional Activation of the Heme Oxygenase Gene by Heme and Cadmium in Mouse Hepatoma Cells

1989 • 230 citations

The glucocorticoid domain: Steroid-mediated changes in the rate of synthesis of rat hepatoma proteins

1978 • 227 citations

Induction of ferritin subunit synthesis by iron is regulated at both the transcriptional and translational levels.

1988 • 214 citations

The glucocorticoid receptor

1991 • 208 citations

Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: A physiologically significant reaction?

1983 • 205 citations

Zinc transfer from transcription factor IIIA fingers to thionein clusters.

1991 • 204 citations

ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene.

1991 • 199 citations

Cathepsin B and its endogenous inhibitors: the role in tumor malignancy

1990 • 187 citations

Steroid-free glucocorticoid receptor binds specifically to mouse mammary tumour virus DNA

1986 • 185 citations

Fine Mapping of a Mouse Metallothionein Gene Metal Response Element

1989 • 185 citations

Changes in the intracellular accumulation and distribution of metallothionein in rat liver and kidney during postnatal development

1983 • 183 citations

Ferritin gene transcription is regulated by iron in soybean cell cultures.

1991 • 183 citations

Metallothionein gene expression and resistance to cisplatin in human ovarian cancer

1990 • 181 citations

Identification of an RNA binding site for human thymidylate synthase.

1993 • 178 citations

Regulation of metallothionein gene expression.

1990 • 177 citations

Superoxide Dismutase and Oxygen Toxicity in a Eukaryote

1974 • 173 citations

Molecular Genetics of Superoxide Dismutases in Yeasts and Related Fungi

1992 • 172 citations

Copper deficiency in ruminants; recent developments

1986 • 163 citations

Superoxide and superoxide dismutase in chemistry, biology and medicine

1987 • 158 citations

Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during development

1987 • 148 citations

Cadmium induces transcription of proto-oncogenes c-jun and c-myc in rat L6 myoblasts.

1990 • 147 citations

Effect of selenium status on mRNA levels for glutathione peroxidase in rat liver

1988 • 145 citations

Superoxide and superoxide dismutase in chemistry, biology and medicine

1987 • 141 citations

Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment.

1990 • 127 citations

Fine mapping of a mouse metallothionein gene metal response element.

1989 • 126 citations

Nuclear Zinc Uptake and Interactions and Metallothionein Gene Expression are Influenced by Dietary Zinc in Rats

1992 • 125 citations

Structural requirements of iron-responsive elements for binding of the protein involved in both transferrin receptor and ferritin mRNA post-transcriptional regulation

1990 • 114 citations

Mechanisms of caeruloplasmin biosynthesis in normal and copper-deficient rats

1992 • 110 citations

Translational repression in eukaryotes: partial purification and characterization of a repressor of ferritin mRNA translation.

1988 • 109 citations

Regulation of 5-aminolevulinate synthase mRNA in different rat tissues.

1988 • 108 citations

The Cu(II)-repressible plastidic cytochrome c. Cloning and sequence of a complementary DNA for the pre-apoprotein.

1987 • 108 citations

Abnormal copper metabolism and deficient lysyl oxidase activity in a heritable connective tissue disorder.

1982 • 108 citations

Toxic milk, a new mutation affecting copper metabolism in the mouse

1983 • 107 citations

Competition for cellular factors that activate metallothionein gene transcription

1984 • 107 citations

G-protein cascades: gain and kinetics

1992 • 104 citations

Differential regulation of the two genes encoding Saccharomyces cerevisiae cytochrome c oxidase subunit V by heme and the HAP2 and REO1 genes.

1988 • 99 citations

Disorders of copper transport

1989 • 96 citations

Menkes syndrome in a girl with X‐autosome translocation

1987 • 95 citations

Evidence for co-regulation of Cu,Zn superoxide dismutase and metallothionein gene expression in yeast through transcriptional control by copper via the ACE 1 factor

1991 • 94 citations

Effect of proteinase inhibitors on intracellular processing of cathepsin B, H and L in rat macrophages

1988 • 94 citations

Dynamic interplay between two copper-titrating components in the transcriptional regulation of cyt c6.

1991 • 90 citations

Mutagenic responses of nickel oxides and nickel sulfides in Chinese hamster V79 cell lines at the xanthine-guanidine phosphoribosyl transferase locus

1993 • 87 citations

Expression of the c-Ha-ras oncogene in mouse NIH 3T3 cells induces resistance to cisplatin.

1991 • 86 citations

Co-ordinate control of synthesis of mitochondrial and non-mitochondrial hemoproteins: a binding site for the HAP1 (CYP1) protein in the UAS region of the yeast catalase T gene (CTT1).

1988 • 85 citations

Binding of hormone accelerates the kinetics of glucocorticoid and progesterone receptor binding to DNA.

1989 • 84 citations

Analysis of the binding sites of chromium to DNA and protein in vitro and in intact cells

1992 • 83 citations

Requirements for the Translational Repression of Ferritin Transcripts in Wheat Germ Extracts by a 90-kDa Protein from Rabbit Liver

1989 • 80 citations

Heme-hemopexin-mediated induction of metallothionein gene expression.

1992 • 78 citations

Interactions of a G-protein with its effector: transducin and cGMP phosphodiesterase in retinal rods

1993 • 78 citations

Activation of Human Monocytes with Lipopolysaccharide Induces Metallothionein Expression and Is Diminished by Zinc

1994 • 70 citations

Antibody-Mediated Activation of Drosophila Heat Shock Factor in Vitro

1990 • 70 citations

Isolation and structural characterization of the Chlamydomonas reinhardtii gene for cytochrome c6. Analysis of the kinetics and metal specificity of its copper-responsive expression

1991 • 69 citations

Uptake and efflux of copper-64 in Menkes'-disease and normal continuous lymphoid cell lines

1987 • 69 citations

Metal Regulatory Elements of the Mouse Metallothionein-I Gene

1987 • 69 citations

Regulation of metallothionein synthesis in HeLa cells by heavy metals and glucocorticoids

1981 • 67 citations

Elements Involved in Oxygen Regulation of the Saccharomyces Cerevisiae CYC7 Gene

1987 • 66 citations

Expression of a Yeast Metallothionein Gene Family Is Activated by a Single Metalloregulatory Transcription Factor

1992 • 66 citations

Zinc dependent binding of a liver nuclear factor to metal response element MRE-a of the mouse metallothionein-l gene and variant sequences

1990 • 65 citations

Metal-specific induction of metallothionein isoforms in the blue crab Callinectes sapidus in response to single- and mixed-metal exposure

1992 • 64 citations

Recombinant platelet-derived growth factor-BB stimulates growth and inhibits differentiation of rat L6 myoblasts.

1991 • 64 citations

Trace Element-Gene Interactions

2009 • 63 citations

Morphologic and chemical studies on a murine mutation (toxic milk mice) resulting in hepatic copper toxicosis.

1988 • 63 citations

The iron regulatory region of ferritin mRNA is also a positive control element for iron-independent translation

1992 • 63 citations

Induction of several acute-phase protein genes by heavy metals: a new class of metal-responsive genes

1991 • 62 citations

Regulation of Glucocorticoid Receptor Function through Assembly of a Receptor‐Heat Shock Protein Complex^a

1993 • 61 citations

Transcription factor MBF-I interacts with metal regulatory elements of higher eucaryotic metallothionein genes.

1989 • 59 citations

Cu,Zn superoxide dismutase and copper deprivation and toxicity in Saccharomyces cerevisiae

1990 • 58 citations

Heavy metals induce expression of the TPA‐inducible sequence (TIS) genes

1991 • 57 citations

P2 protamines from human sperm are zinc -finger proteins with one Cys2His2 motif

1992 • 57 citations

Heavy metal ions in transcription factors from HeLa cells: Sp1, but not octamer transcription factor requires zinc for DNA binding and for activator function

1988 • 57 citations

Regulation of the ontogeny of rat liver metallothionein mRNA by zinc

1987 • 54 citations

Antisense down-regulation of metallothionein in a human monocytic cell line alters adherence, invasion, and the respiratory burst.

1994 • 54 citations

Induction of metallothionein synthesis by zinc in cadmium pretreated rats

1990 • 51 citations

A nuclear factor binds to the metal regulatory elements of the mouse gene encoding metallothionein-I

1991 • 50 citations

Kinetics of Cu(II) transport and accumulation by hepatocytes from copper-deficient mice and the brindled mouse model of Menkes disease.

1983 • 48 citations

Elements involved in oxygen regulation of the Saccharomyces cerevisiae CYC7 gene.

1987 • 44 citations

Elevation of rat liver mRNA for selenium-dependent glutathione peroxidase by selenium deficiency.

1990 • 44 citations

Expression of a yeast metallothionein gene family is activated by a single metalloregulatory transcription factor.

1992 • 41 citations

Zinc‐specific activation of a HeLa cell nuclear protein which interacts with a metal responsive element of the human metallothionein‐II_A gene

1992 • 40 citations

Copper and gene regulation in yeast.

1993 • 38 citations

A nuclear factor that recognizes the metal-responsive elements of human metallothionein IIA gene.

1992 • 37 citations

A nuclear factor requires Zn24 to bind a regulatory MRE element of the mouse gene encoding metallothionein-1

1991 • 35 citations

Induction of metallothionein synthesis by cadmium and zinc in cultured rabbit kidney cells (RK-13)

1993 • 33 citations

Altered cisplatin and cadmium resistance and cell survival in Chinese hamster ovary cells expressing mouse metallothionein.

1993 • 31 citations

The structure of glucocorticoid receptors

1993 • 30 citations

Effects of Cellular Copper Content on Copper Uptake and Metallothionein and Ceruloplasmin mRNA Levels in Mouse Hepatocytes

1990 • 29 citations

Zinc treatment, metallothionein expression, and resistance to cisplatin in mouse melanoma cells

1990 • 29 citations

A new puzzle in selenoprotein biosynthesis: selenocysteine seems to be encoded by the ‘stop’ codon, UGA

1987 • 28 citations

In vitro degradation of apo-, zinc-, and cadmium-metallothionein by cathepsins B, C, and D

1992 • 26 citations

Degradation and metal composition of hepatic isometallothioneins in rats

1992 • 26 citations

Sperm chromatin stability and zinc binding properties in semen from men in barren unions

1992 • 25 citations

A mutant mouse (tx) with increased hepatic metallothionein stability and accumulation

1993 • 23 citations

Defining conditions for the efficient in vitro cross-linking of proteins to DNA by chromium(III) compounds

1992 • 22 citations

Role of hepatic lysosomes in the degradation of metallothionein

1992 • 20 citations

Degradation of cadmium metallothionein in vitro by lysosomal proteases

1992 • 20 citations

Copper Metabolism in Menkes Disease1

2015 • 20 citations

Metalloregulatory proteins and molecular mechanisms of heavy metal signal transduction.

1990 • 19 citations

Nutrient Effects on DNA and Chromatin Structure

1987 • 18 citations

Diverse forms of stress results in changes in cellular levels of osteonectin/SPARC without altering mRNA levels in osteoligament cells

1991 • 18 citations

Trace Metal Metabolism in Cultured Skin Fibroblasts of the Mottled Mouse: Response to Metallothionein Inducers

1984 • 16 citations

Cadmium, zinc, and copper metabolism in the mottled mouse, an animal model for menkes' kinky hair syndrome

1983 • 14 citations

Cadmium interacts with the zinc-dependent stability of the human sperm chromatin.

1987 • 9 citations

G-proteins and the role of second messengers in the regulation of the human neutrophil.

1992 • 8 citations

Rates of Metallothionein Synthesis, Degradation and Accretion in a Chicken Macrophage Cell Line

1990 • 6 citations

Metallothionein and Ceruloplasmin Genes

1988 • 4 citations

The Regulation of Glutathione Peroxidase Gene Expression; Implication for Species Difference and the Effect of Dietary Selenium Manipulation

1989 • 4 citations

DEFECTIVE INTRACELLULAR COPPER TRANSLOCATION IN MENKES KINKY HAIR SYNDROME

1987 • 4 citations