Heavy metals induce expression of the TPA‐inducible sequence (TIS) genes

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Hybridization of nucleic acids immobilized on solid supports

1984 • 1,357 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

Steroid Receptors: Elements for Modulation of Eukaryotic Transcription

1976 • 688 citations

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

1988 • 580 citations

A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

1988 • 532 citations

In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: Part 1

1980 • 477 citations

Down-regulation of protein kinase C is due to an increased rate of degradation

1987 • 442 citations

A 12-base-pair DNA motif that is repeated several times in metallothionein gene promoters confers metal regulation to a heterologous gene.

1984 • 424 citations

Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

1987 • 360 citations

Cascade Induction of c-fos, c-myc, and Heat Shock 70K Transcripts during Regression of the Rat Ventral Prostate Gland

1988 • 355 citations

Regulation, linkage, and sequence of mouse metallothionein I and II genes.

1984 • 335 citations

Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoids

1984 • 331 citations

A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens.

1987 • 292 citations

Regulation of metallothionein–thymidine kinase fusion plasmids injected into mouse eggs

1982 • 283 citations

Androgen‐repressed messages in the rat ventral prostate

1986 • 261 citations

A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence.

1990 • 247 citations

Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein.

1990 • 247 citations

Transcriptional Activation of the Heme Oxygenase Gene by Heme and Cadmium in Mouse Hepatoma Cells

1989 • 230 citations

Nucleotide sequence and organization of the rat heme oxygenase gene.

1987 • 210 citations

Transcriptional repression in eukaryotes

1990 • 210 citations

Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5′-flanking DNA

1984 • 195 citations

Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor.

1989 • 188 citations

Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes.

1986 • 183 citations

Constitutive and metal-inducible protein:DNA interactions at the mouse metallothionein I promoter examined by in vivo and in vitro footprinting.

1988 • 176 citations

Protein kinase activity associated with a phorbol ester receptor purified from mouse brain.

1983 • 175 citations

Duplicated heavy metal control sequences of the mouse metallothionein-I gene.

1984 • 167 citations

Cadmium induces transcription of proto-oncogenes c-jun and c-myc in rat L6 myoblasts.

1990 • 147 citations

The Heat Shock Response in HeLa Cells is Accompanied by Elevated Expression of the c-fos Proto-Oncogene

1987 • 147 citations

Calcium channel antagonists delay regression of androgen‐dependent tissues and suppress gene activity associated with cell death

1988 • 128 citations

The heat shock response in HeLa cells is accompanied by elevated expression of the c-fos proto-oncogene.

1987 • 106 citations

Early gene regulation by nerve growth factor in PC12 cells: induction of an interferon-related gene.

1989 • 103 citations

Demonstration in living cells of an intragenic negative regulatory element within the rodent c-fos gene

1990 • 96 citations

Gene expression during the early phases of regression of the androgen-dependent Shionogi mouse mammary carcinoma.

1988 • 88 citations

Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter.

1987 • 87 citations

Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3 variants can occur through protein kinase C-dependent and -independent pathways.

1989 • 59 citations

Metal-dependent binding of a nuclear factor to the rat metallothionein-I promoter

1990 • 49 citations

Activation of heme oxygenase and heat shock protein 70 genes by stress in human hepatoma cells

1990 • 46 citations

The tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid differ in toxicity, mitogenic activity and induction of gene expression

1989 • 42 citations