Role of hepatic lysosomes in the degradation of metallothionein

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Methods in Enzymology , Vol

1966 • 26,261 citations

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Molecular Cell Biology

1986 • 5,808 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

METALLOTHIONEIN

1986 • 1,606 citations

A CADMIUM PROTEIN FROM EQUINE KIDNEY CORTEX

1957 • 1,295 citations

A simple ultraviolet spectrophotometric method for the determination of protein.

1956 • 1,266 citations

Metallothionein: a Cadmium- and Zinc-containing Protein from Equine Renal Cortex

1960 • 965 citations

Gel electrophoresis of proteins: A practical approach

1982 • 798 citations

Metallothionein: a Cadmium and Zinc-containing Protein from Equine Renal Cortex

1961 • 685 citations

Control of Enzyme Levels in Animal Tissues

1970 • 680 citations

Lysosomes : their role in protein breakdown

1987 • 435 citations

Molecular cell biology

1987 • 396 citations

Lysosomes: A laboratory handbook

1978 • 367 citations

Influence of turnover rates on the responses of enzymes to cortisone.

1965 • 348 citations

Protein Turnover and Lysosome Function

1978 • 279 citations

Domain nature of metallothionein.

1982 • 273 citations

Quantitative relationship between autophagy and proteolysis during graded amino acid deprivation in perfused rat liver.

1981 • 223 citations

Nutritional and Physiological Significance of Metallothionein

1987 • 204 citations

Ligand substitution reactions of metallothioneins with EDTA and apo-carbonic anhydrase.

1980 • 190 citations

Regulation of Protein Degradation in Mammalian Tissues

1970 • 184 citations

Regulation of metallothionein gene expression.

1990 • 177 citations

Quantitative correlation between proteolysis and macro- and microautophagy in mouse hepatocytes during starvation and refeeding.

1983 • 171 citations

Relationship between in vivo degradative rates and isoelectric points of proteins.

1975 • 171 citations

Biological function of metallothionein

1975 • 160 citations

Order of metal binding in metallothionein.

1983 • 152 citations

Acetyl-Coenzyme-A Carboxylase from Rat Liver. Subunit Structure and Proteolytic Modification

1975 • 151 citations

Preparation of rat liver lysosomes

1967 • 147 citations

Human fetal liver contains both zinc- and copper-rich forms of metallothionein.

1980 • 145 citations

RESISTANCE OF METAL COMPLEXES OF CONALBUMIN AND TRANSFERRIN TO PROTEOLYSIS AND TO THERMAL DENATURATION

1958 • 141 citations

Multifunctional control of amino acids of deprivation-induced proteolysis in liver. Role of leucine.

1982 • 139 citations

Products of metal exchange reactions of metallothionein

1985 • 131 citations

Properties of the apoprotein and role of copper and zinc in protein conformation and enzyme activity of bovine superoxide dismutase

1972 • 126 citations

Degradation of hepatic zinc-thionein after parenteral zinc administration

1976 • 121 citations

Circular dichroism of metallothioneins

1978 • 121 citations

Uptake and degradation of proteins by isolated rat liver lysosomes. Suggestion of a microautophagic pathway of proteolysis.

1982 • 118 citations

Degradation of rat liver metallothioneins in vitro

1978 • 97 citations

A critical reappraisal of Waddell's technique for ultraviolet spectrophotometric protein estimation

1983 • 90 citations

Hepatic lysosomal copper protein in dogs with an inherited copper toxicosis

1981 • 80 citations

Species differences in the occurrence of copper-metallothionein in the particulate fractions of the liver of copper-loaded animals

1984 • 66 citations

Separation and quantitation of metallothioneins by high-performance liquid chromatography coupled with atomic absorption spectrophotometry

1986 • 64 citations

Kidney synthesizes less metallothionein than liver in response to cadmium chloride and cadmium-metallothionein

1988 • 55 citations

Structural equivalents of latency for lysosome hydrolases

1975 • 54 citations

Silver staining for carboxymethylated metallothioneins in polyacrylamide gels

1988 • 49 citations

Artificial substrates in the assay of acid glycosidases

1972 • 46 citations

Autophagic degradation in rat liver after vinblastine treatment

1980 • 43 citations

Intracellular Protein Catabolism II

1977 • 42 citations

Interprotein Metal Exchange Reactions of Metallothionein

1987 • 41 citations

Peptide intermediates in the degradation of cellular proteins. Bestatin permits their accumulation in mouse liver in vivo.

1983 • 37 citations

The type II arylsulphatases of the red kangaroo

1971 • 26 citations

Solid-phase peptide synthesis of the .alpha. and .beta. domains of human liver metallothionein 2 and the metallothionein of Neurospora crassa

1990 • 23 citations

Studies on the structure of ferritin and apoferritin from horse spleen

1971 • 23 citations

Peptide intermediates in the degradation of cellular proteins.

1985 • 20 citations

Degradation of Zinc-Metallothionein in Monolayer Cultures of Rat Hepatocytes

1989 • 19 citations

Isolation of rat liver lysosomes by a single two-phase partition on dextran/polyethylene glycol

1990 • 19 citations

[17] Detection of carboxymethylmetallothionein by sodium dodecyl sulfate-polyacrylamide gel electrophoresis

1991 • 16 citations

Isolation and identification of acetyl‐CoA carboxylase from rainbow trout (Salmo gairdneri) liver

1989 • 12 citations

LYSOSOMAL PROTEINASES AND THEIR SPECIFICITY

1978 • 11 citations

Arginylation, Surface Hydrophobicity and Degradation of Cytosol Proteins from Rat Hepatocytes

1988 • 10 citations

LYSOSOMAL MECHANISMS OF PROTEIN DEGRADATION

1978 • 9 citations

FACTORS INVOLVED IN THE REGULATION OF PROTEIN TURNOVER11Supported by grants from the National Institutes of Health (AM–18187 and AM–08873).

1978 • 9 citations

Roles of synthesis and degradation in the regulation of metallothionein accretion in a chicken macrophage-cell line

1990 • 8 citations

The effect of pH and lysosomal extract on rat liver metallothionein (Cd-thionein)

1985 • 7 citations

Activity measurement of lysosomal cysteine proteinases, cathepsins B, H and L, in crude tissue extracts, and their relation to the fractional rate of protein degradation

1990 • 6 citations

Intracellular Protein Catabolism in Vitro and in Vivo

1977 • 3 citations

A Copper-sulfur complex in the liver of a patient with wilson’s disease

1986 • 3 citations