Overexpression of Metallothionein Confers Resistance to Anticancer Drugs

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

1987 • 3,809 citations

METALLOTHIONEIN

1986 • 1,606 citations

The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes

1987 • 533 citations

X-Ray Structure of the Major Adduct of the Anticancer Drug Cisplatin with DNA: cis -[Pt(NH ₃ ) ₂ {d(pGpG)}]

1985 • 403 citations

Transition series metals and sulfhydryl reagents induce the synthesis of four proteins in eukaryotic cells

1980 • 343 citations

Statistical Quality Control of Radioimmunoassays¹

1968 • 333 citations

Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum(II).

1987 • 288 citations

A semiautomated microculture method for investigating growth inhibitory effects of cytotoxic compounds on exponentially growing carcinoma cells

1984 • 198 citations

Metallothionein-mediated cisplatin resistance in human ovarian carcinoma cells

1987 • 175 citations

Resistance against cis-dichlorodiammineplatinum in cultured cells with a high content of metallothionein

1981 • 168 citations

Alkylating agents: in vitro studies of cross-resistance patterns in human cell lines.

1986 • 156 citations

Alkylating agent resistance: in vitro studies with human cell lines.

1985 • 137 citations

[9] Radioimmunoassay of metallothioneins

1982 • 117 citations

Cell specificity and an effect of ras on human metallothionein gene expression.

1986 • 114 citations

Induction of metallothionein-I mRNA in cultured cells by heavy metals and iodoacetate: evidence for gratuitous inducers.

1984 • 112 citations

Elevated expression of thymidylate synthase cycle genes in cisplatin-resistant human ovarian carcinoma A2780 cells.

1988 • 98 citations

Structure and expression of two human metallothionein-I isoform genes and a related pseudogene.

1985 • 86 citations

Increased resistance to chlorambucil in cultured cells with a high concentration of cytoplasmic metallothionein.

1983 • 83 citations

Binding of cis-dichlorodiammine platinum(II) to metallothionein in Ehrlich cells

1985 • 64 citations

Zinc effects on glutathione metabolism relationship to zinc-induced protection from alkylating agents

1983 • 49 citations

Studies on the resistance of a murine leukemia L1210 cell line to cis-diamminedichloroplatinium(II)

1981 • 44 citations

Enhanced bleomycin-induced DNA damage and cytotoxicity with calmodulin antagonists.

1985 • 43 citations

Comparison of methods of metallothionein quantification: Cadmium radioassay, mercury radioassay, and radioimmunoassay

1985 • 31 citations

Zinc-induced resistance to alkylating agent toxicity.

1982 • 28 citations

Metallothionein – A Unique Protein with Multiple Detoxifying Properties?

1984 • 22 citations

Characteristics of b-type cytochromes in brain microsomes: Comparison with liver microsomes

1984 • 9 citations