The glucocorticoid receptor

Gene regulation by steroid hormones

1989 • 3,466 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor

1987 • 1,920 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Heat shock proteins.

1990 • 1,365 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene

1987 • 760 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region

1983 • 700 citations

DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo

1983 • 692 citations

The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus

1983 • 619 citations

Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain

1990 • 609 citations

Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

1988 • 600 citations

Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter.

1987 • 597 citations

Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit β-globin gene in mouse 3T6 cells

1983 • 596 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

Steroid hormone receptors compete for factors that mediate their enhancer function

1989 • 580 citations

The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

1988 • 522 citations

Many Transcription Factors Interact Synergistically with Steroid Receptors

1988 • 517 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element

1989 • 507 citations

Negative Regulation by Glucocorticoids Through Interference with a cAMP Responsive Enhancer

1988 • 502 citations

Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein.

1985 • 492 citations

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene.

1988 • 485 citations

Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid-dependent enhancer element

1984 • 449 citations

Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo

1987 • 448 citations

Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones

1984 • 442 citations

Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter

1990 • 440 citations

Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor

1987 • 434 citations

A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor

1988 • 427 citations

The N-terminal region of the chicken progesterone receptor specifies target gene activation

1988 • 425 citations

Synergistic action of the glucocorticoid receptor with transcription factors.

1988 • 407 citations

The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction.

1986 • 406 citations

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

1987 • 398 citations

Evidence That the 90-kDa Heat Shock Protein Is Necessary for the Steroid Binding Conformation of the L Cell Glucocorticoid Receptor

1989 • 394 citations

The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins.

1986 • 392 citations

Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor

1988 • 370 citations

Glucocorticoid and progesterone receptors bind to the same sites in two hormonally regulated promoters

1985 • 366 citations

Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor

1989 • 358 citations

Characterization of response elements for androgens, glucocorticoids and progestins in mouse mammary tumour virus

1988 • 347 citations

Molybdate inhibition of glucocorticoid receptor inactivation and transformation.

1979 • 339 citations

In vivo protein–DNA interactions in a glucocorticoid response element require the presence of the hormone

1986 • 328 citations

Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome.

1988 • 316 citations

Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor.

1987 • 299 citations

The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific

1989 • 299 citations

Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding

1984 • 281 citations

Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements

1989 • 270 citations

Signal Transduction and Transcriptional Regulation by Glucocorticoid Receptor-LexA Fusion Proteins

1988 • 268 citations

A region in the steroid binding domain determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex.

1988 • 267 citations

Glucocorticoid Receptor Binding to a Specific DNA Sequence Is Required for Hormone-Dependent Repression of Pro-Opiomelanocortin Gene Transcription

1989 • 265 citations

A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors

1986 • 261 citations

Acidophilic activation of steroid hormone receptors

1973 • 260 citations

Glucocorticoid Receptor Mutants That Define a Small Region Sufficient for Enhancer Activation

1987 • 260 citations

Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities.

1989 • 240 citations

Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain

1988 • 238 citations

Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene.

1985 • 235 citations

Tissue-specific regulation of glucocorticoid receptor mRNA by dexamethasone.

1987 • 229 citations

Down-regulation and Phosphorylation of Glucocorticoid Receptors in Cultured Cells

1989 • 223 citations

Differential gene activation by glucocorticoids and progestins through the hormone regulatory element of mouse mammary tumor virus

1988 • 205 citations

Direct demonstration of glucocorticoid receptor phosphorylation by intact L-cells.

1983 • 200 citations

Metal binding ‘finger’ structures in the glucocorticoid receptor defined by site-directed mutagenesis.

1988 • 199 citations

Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid-responsive elements.

1987 • 197 citations

Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state

1988 • 186 citations

Steroid-free glucocorticoid receptor binds specifically to mouse mammary tumour virus DNA

1986 • 185 citations

DNA sequences outside the receptor-binding sites differently modulate the responsiveness of the mouse mammary tumour virus promoter to various steroid hormones.

1988 • 184 citations

The Adenovirus Major Late Transcription Factor Activates the Rat γ-Fibrinogen Promoter

1987 • 177 citations

Domains of the Glucocorticoid Receptor Involved in Specific and Nonspecific Deoxyribonucleic Acid Binding, Hormone Activation, and Transcriptional Enhancement

1987 • 174 citations

The non-DNA-binding heterooligomeric form of mammalian steroid hormone receptors contains a hsp90-bound 59-kilodalton protein.

1990 • 174 citations

Interaction of the TGGCA-binding protein with upstream sequences is required for efficient transcription of mouse mammary tumor virus.

1987 • 168 citations

Distinct sequence elements involved in the glucocorticoid regulation of the mouse mammary tumor virus promoter identified by linker scanning mutagenesis

1986 • 158 citations

The Purified Activated Glucocorticoid Receptor is a Homodimer

1989 • 156 citations

Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription.

1989 • 156 citations

Activation of steroid hormone–receptor complexes in intact target cells in physiological conditions

1979 • 152 citations

Initiation of translation of the cauliflower mosaic virus genome from a polycistronic mRNA: evidence from deletion mutagenesis

1984 • 152 citations

Subunit dissociation as a possible mechanism of glucocorticoid receptor activation

1983 • 150 citations

Mapping the HSP90 binding region of the glucocorticoid receptor.

1990 • 144 citations

Glucocorticoid receptor binds cooperatively to adjacent recognition sites.

1989 • 142 citations

The molybdate-stabilized nonactivated glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein.

1987 • 139 citations

Nuclear factor I acts as a transcription factor on the MMTV promoter but competes with steroid hormone receptors for DNA binding.

1990 • 136 citations

Transcriptional inhibition by a glucocorticoid receptor-β-galactosidase fusion protein

1988 • 129 citations

Identification of cysteine 656 as the amino acid of hepatoma tissue culture cell glucocorticoid receptors that is covalently labeled by dexamethasone 21-mesylate.

1987 • 125 citations

The nucleotide sequences recognized by the glucocorticoid receptor in the rabbit uteroglobin gene region are located far upstream from the initiation of transcription.

1984 • 125 citations

Evidence for intracellular association of the glucocorticoid receptor with the 90-kDa heat shock protein.

1988 • 124 citations

Identification of hormone-interacting amino acid residues within the steroid-binding domain of the glucocorticoid receptor in relation to other steroid hormone receptors.

1988 • 121 citations

Glucocorticoid regulation of mouse mammary tumor virus: identification of a short essential DNA region.

1983 • 115 citations

Hormone-dependent phosphorylation of the glucocorticoid receptor occurs mainly in the amino-terminal transactivation domain.

1990 • 112 citations

Enhancer and promoter elements directing activation and glucocorticoid repression of the alpha 1-fetoprotein gene in hepatocytes.

1988 • 110 citations

In Vitro Transcription Enhancement by Purified Derivatives of the Glucocorticoid Receptor

1989 • 107 citations

Synergism of closely adjacent estrogen-responsive elements increases their regulatory potential

1988 • 105 citations

The transformed glucocorticoid receptor has a lower steroid-binding affinity than the nontransformed receptor

1990 • 103 citations

Phosphorylation of rat liver glucocorticoid receptor.

1985 • 94 citations

Activation of liver and kidney glucocorticoid-receptor complexes occurs in vivo

1980 • 91 citations

Functional analysis of the steroid hormone control region of mouse mammary tumor virus

1984 • 84 citations

Cooperativity and specificity in the interactions between DNA and the glucocorticoid receptor DNA binding domain

1990 • 83 citations

Molybdate-stabilized glucocorticoid receptor: evidence for a receptor heteromer

1985 • 81 citations

Steroid Binding Activity Is Retained in a 16-kDa Fragment of the Steroid Binding Domain of Rat Glucocorticoid Receptors

1989 • 75 citations

Localization of phosphorylation sites with respect to the functional domains of the mouse L cell glucocorticoid receptor.

1988 • 70 citations

Functional analysis of the glucocorticoid regulatory elements present in the mouse mammary tumor virus long terminal repeat

1986 • 68 citations

Chemical cross-linking of heteromeric glucocorticoid receptors

1988 • 64 citations

Elimination and reconstitution of the requirement for hormone in promoting temperature-dependent transformation of cytosolic glucocorticoid receptors to the DNA-binding state.

1990 • 53 citations

Activation of the dioxin and glucocorticoid receptors to a DNA binding state under cell-free conditions.

1990 • 51 citations

Limited proteolysis of the mouse liver glucocorticoid receptor

1983 • 51 citations

Hormonal Induction of Transfected Genes Depends on DNA Topology

1990 • 46 citations

Hormonal induction of transfected genes depends on DNA topology.

1990 • 32 citations

Antibodies to Steroid Receptor Deoxyribonucleic Acid Binding Domains and their Reactivity with the Human Glucocorticoid Receptor

1988 • 31 citations

Purification and characterization of two novel phosphoglycerides that modulate the glucocorticoid-receptor complex. Evidence for two modulator binding sites in the occupied/unactivated steroid hormone receptor.

1990 • 28 citations