Retrieval of TGN proteins from the cell surface requires endosomal acidification.

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

Lysosomotropic agents

1974 • 1,887 citations

Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation.

1993 • 1,125 citations

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

1987 • 949 citations

Cholesterol and the Golgi Apparatus

1993 • 819 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2

1987 • 699 citations

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

1992 • 688 citations

Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.

1992 • 628 citations

Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity

1990 • 618 citations

PROTEIN DEGRADATION IN CULTURED CELLS

1974 • 603 citations

Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts

1981 • 593 citations

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gpl60

1992 • 572 citations

Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process.

1993 • 516 citations

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.

1994 • 494 citations

Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylation

1985 • 448 citations

Movement of internalized ligand–receptor complexes along a continuous endosomal reticulum

1990 • 428 citations

Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances.

1981 • 424 citations

Retrieval of transmembrane proteins to the endoplasmic reticulum.

1993 • 414 citations

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

1990 • 378 citations

Structural relationships between clathrin assembly proteins from the Golgi and the plasma membrane.

1988 • 356 citations

Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38)

1990 • 355 citations

The isolation and sequence of the gene encoding T8: A molecule defining functional classes of T lymphocytes

1985 • 325 citations

Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention.

1991 • 296 citations

Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.

1990 • 296 citations

Subcellular organization of glycosylation in mammalian cells

1987 • 271 citations

Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence.

1993 • 258 citations

Chloroquine and ammonium ion inhibit receptor-mediated endocytosis of mannose-glycoconjugates by macrophages: Apparent inhibition of receptor recycling

1980 • 252 citations

The Ways of Endocytosis

1989 • 237 citations

The membrane spanning domain of beta-1,4-galactosyltransferase specifies trans Golgi localization.

1991 • 237 citations

100-kD coated vesicle proteins: molecular heterogeneity and intracellular distribution studied with monoclonal antibodies

1987 • 234 citations

TGN38 is maintained in the trans-Golgi network by a tyrosine-containing motif in the cytoplasmic domain.

1993 • 231 citations

Intracellular movement of cell surface receptors after endocytosis: resialylation of asialo-transferrin receptor in human erythroleukemia cells.

1985 • 229 citations

Perturbation of the morphology of the trans-Golgi network following Brefeldin A treatment: redistribution of a TGN-specific integral membrane protein, TGN38.

1992 • 226 citations

Overlapping distribution of two glycosyltransferases in the Golgi apparatus of HeLa cells.

1993 • 217 citations

Mutation of a tyrosine localization signal in the cytosolic tail of yeast Kex2 protease disrupts Golgi retention and results in default transport to the vacuole.

1992 • 209 citations

Tubular early endosomal networks in AtT20 and other cells.

1991 • 208 citations

Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2

1990 • 202 citations

Recycling of proteins from the Golgi compartment to the ER in yeast.

1990 • 196 citations

Differential subcompartmentation of terminal glycosylation in the Golgi apparatus of intestinal absorptive and goblet cells.

1986 • 172 citations

Maturation models for endosome and lysosome biogenesis

1991 • 172 citations

Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation.

1990 • 171 citations

Sorting of membrane proteins in the secretory pathway

1993 • 171 citations

Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3.

1991 • 162 citations

The arguments for pre-existing early and late endosomes

1991 • 156 citations

Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme.

1991 • 155 citations

Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport.

1993 • 144 citations

Chloroquine reduces the number of asialo-glycoprotein receptors in the hepatocyte plasma membrane

1979 • 144 citations

TGN38/41 recycles between the cell surface and the TGN: brefeldin A affects its rate of return to the TGN.

1993 • 143 citations

Evidence for involvement of furin in cleavage and activation of diphtheria toxin.

1993 • 137 citations

A cytosolic complex of p62 and rab6 associates with TGN38/41 and is involved in budding of exocytic vesicles from the trans-Golgi network

1993 • 133 citations

The SXYQRL sequence in the cytoplasmic domain of TGN38 plays a major role in trans-Golgi network localization.

1993 • 121 citations

Targeting and retention of Golgi membrane proteins

1993 • 110 citations

Expression of mouse furin in a Chinese hamster cell resistant to Pseudomonas exotoxin A and viruses complements the genetic lesion.

1993 • 109 citations

Polyoma and hamster papovavirus large T antigen-mediated replication of expression shuttle vectors in Chinese hamster ovary cells

1991 • 101 citations

Analysis of the effect of amines on inhibition of receptor-mediated and fluid-phase pinocytosis in rabbit alveolar macrophages

1981 • 88 citations

cDNA cloning for a bile canaliculus domain-specific membrane glycoprotein of rat hepatocytes.

1987 • 66 citations

Ligand- and weak base-induced redistribution of asialoglycoprotein receptors in hepatoma cells.

1987 • 51 citations

Mannosidase II and the 135-kDa Golgi-specific antigen recognized monoclonal antibody 53FC3 are the same dimeric protein.

1990 • 46 citations

Tubular early endosomal networks in AtT20 and other cells

1992 • 33 citations

The Yeast KEX-2-Processing Endoprotease Is Active in the Golgi Apparatus of Transfected NIH 3T3 Fibroblasts

1990 • 26 citations