CD4+ T Cell Response to Factor VIII in Hemophilia A, Acquired Hemophilia, and Healthy Subjects

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

The Th1/Th2 paradigm

1997 • 1,102 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Structure of human factor VIII

1984 • 898 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Natural autoantibodies: from ‘horror autotoxicus’ to ‘gnothi seauton’

1991 • 723 citations

Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells

1989 • 706 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs

1992 • 613 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Acquisition of immunologic self-tolerance

1989 • 484 citations

Recombinant Factor VIII for the Treatment of Previously Untreated Patients with Hemophilia A -- Safety, Efficacy, and Development of Inhibitors

1993 • 482 citations

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

1997 • 460 citations

Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.

1990 • 307 citations

Isolation of myelin basic protein-reactive T-cell lines from normal human blood

1983 • 270 citations

Characteristic mRNA abnormality found in half the patients with severe haemophilia A is due to large DNA inversions

1993 • 263 citations

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.

1996 • 260 citations

Differential ability of T cell subsets to undergo activation-induced cell death

1997 • 188 citations

9 Acquired inhibitors

1996 • 186 citations

Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols.

1993 • 184 citations

Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site

1995 • 181 citations

The Inhibitor Antibody Response Is More Complex in Hemophilia A Patients Than in Most Nonhemophiliacs With Factor VIII Autoantibodies

1997 • 180 citations

Factor VIII gene inversions causing severe hemophilia A originate almost exclusively in male germ cells

1994 • 176 citations

Th2 cell clonal anergy as a consequence of partial activation.

1994 • 175 citations

The natural history of factor VIII:C inhibitors in patients with hemophilia A: a national cooperative study. II. Observations on the initial development of factor VIII:C inhibitors

1988 • 171 citations

Frequency of inhibitor development in haemophiliacs treated with low-purity factor VIII

1993 • 164 citations

Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction

1993 • 155 citations

Identification of two promiscuous T cell epitopes from tetanus toxin

1990 • 145 citations

Residues 484-508 Contain a Major Determinant of the Inhibitory Epitope in the A2 Domain of Human Factor VIII

1995 • 137 citations

Molecular etiology of factor VIII deficiency in hemophilia A

1995 • 131 citations

Loss of high‐responder inhibitors in patients with severe hemophilia A and human immunodeficiency virus type 1 infection: A report from the multi‐center hemophilia cohort study

1993 • 118 citations

Healthy subjects produce both anti-factor VIII and specific anti-idiotypic antibodies.

1994 • 105 citations

Mapping the major human T helper epitopes of tetanus toxin. The emerging picture.

1993 • 104 citations

Myasthenia gravis: recognition of a human autoantigen at the molecular level

1993 • 104 citations

T cell proliferative response induced by DNA topoisomerase I in patients with systemic sclerosis and healthy donors.

1995 • 99 citations

Some Human Inhibitor Antibodies Interfere With Factor VIII Binding to Factor IX

1998 • 94 citations

Prevention of experimental myasthenia gravis by nasal administration of synthetic acetylcholine receptor T epitope sequences.

1997 • 88 citations

Inhibitors in hemophilia patients: Current status and management

1994 • 84 citations

A circulating anticoagulant in gamma-1A-multiple myeloma: its modification by penicillin.

1965 • 79 citations

Factor VIII inhibitors: structure and function in autoantibody and hemophilia A patients.

1994 • 76 citations

Human T cell clones reactive against U-small nuclear ribonucleoprotein autoantigens from connective tissue disease patients and healthy individuals.

1993 • 74 citations

The incidence of factor VIII inhibitors in patients with severe hemophilia A

1995 • 71 citations

Common inhibitory effects of human anti‐C2 domain inhibitor alloantibodies on factor VIII binding to von Willebrand factor

1995 • 69 citations

Incidence of Factor VIII Inhibitor Development in Hemophilia A Patients Treated with Less Pure Plasma Derived Concentrates

1994 • 69 citations

Factor VIII inhibitors.

1997 • 63 citations

A Macroglobulin with Inhibitory Activity Against Coagulation Factor VIII

1970 • 62 citations

Noncoagulation inhibitory factor VIII antibodies after induction of tolerance to factor VIII in hemophilia A patients

1990 • 60 citations

Factor VIII immunogenicity

1998 • 60 citations

Spectrum of Mutations in CRM-Positive and CRM-Reduced Hemophilia A

1993 • 58 citations

Epidemiology of Inhibitors in Haemophilia A

1996 • 56 citations

Epitopes on the beta subunit of human muscle acetylcholine receptor recognized by CD4+ cells of myasthenia gravis patients and healthy subjects.

1994 • 56 citations

The genetic basis of inhibitor development in haemophilia A

1998 • 53 citations

Recognition of human insulin in the context of HLA-DRB1*0406 products by T cells of insulin autoimmune syndrome patients and healthy donors.

1993 • 48 citations

Factor VIII Inhibitors in Patients with Hemophilia A: Epidemiology of Inhibitor Development and Induction of Immune Tolerance for Factor VIII

1995 • 47 citations

Epitopes for human CD4⁺ cells on diphtheria toxin: Structural features of sequence segments forming epitopes recognized by most subjects

1995 • 44 citations

T Lymphocyte Proliferative Responses Induced by Recombinant Factor VIII in Hemophilia A Patients with Inhibitors

1996 • 40 citations

Epitope Repertoire of Human CD4+ T Cells on Tetanus Toxin: Identification of Immunodominant Sequence Segments

1997 • 38 citations

Subcutaneous administration of T-epitope sequences of the acetylcholine receptor prevents experimental myasthenia gravis

1999 • 38 citations

Antibodies to factor VIII in plasma of patients with hemophilia A and normal subjects

1996 • 36 citations

CD4+ T-cell subsets and cytokines involved in peripheral tolerance

1997 • 34 citations

Minireview The role of anergy in peripheral T cell unresponsiveness

1994 • 28 citations

Viral safety and inhibitor development associated with monoclonal antibody-purified F VIII C

1991 • 27 citations

Choices Following Antigen Entry: Antibody Formation or Immunologic Tolerance?

1995 • 26 citations

An IgM Circulating Anticoagulant with Factor VIII Inhibitory Activity

1972 • 21 citations

Structure and function of Factor VIII

1995 • 20 citations

T cell sensitization to factor VIII in haemophilia A?

1991 • 16 citations

IgA inhibitor to factor VIII/von Willebrand factor

1985 • 8 citations