Common inhibitory effects of human anti‐C2 domain inhibitor alloantibodies on factor VIII binding to von Willebrand factor

Molecular cloning of a cDNA encoding human antihaemophilic factor

1984 • 937 citations

Structure of human factor VIII

1984 • 898 citations

Expression of active human factor VIII from recombinant DNA clones

1984 • 699 citations

The role of phospholipid and factor VIIIa in the activation of bovine factor X.

1981 • 590 citations

Stabilization of Factor VIII in Plasma by the von Willebrand Factor

1977 • 421 citations

The factor VIII complex: structure and function

1981 • 408 citations

A More Uniform Measurement of Factor VIII Inhibitors

1975 • 316 citations

A Factor VIII Neutralizing Monoclonal Antibody and a Human Inhibitor Alloantibody Recognizing Epitopes in the C2 Domain Inhibit Factor VIII Binding to von Willebrand Factor and to Phosphatidylserine

1993 • 199 citations

Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserine

1990 • 198 citations

A role for the C2 domain of factor VIII in binding to von Willebrand factor

1994 • 192 citations

Effect of von Willebrand factor coexpression on the synthesis and secretion of factor VIII in Chinese hamster ovary cells.

1989 • 178 citations

A new von Willebrand factor (vWF) defect in a patient with factor VIII (FVIII) deficiency but with normal levels and multimeric patterns of both plasma and platelet vWF. Characterization of abnormal vWF/FVIII interaction

1990 • 152 citations

Localization of human factor FVIII inhibitor epitopes to two polypeptide fragments.

1985 • 144 citations

Structural basis for the decreased procoagulant activity of human factor VIII compared to the porcine homolog

1991 • 126 citations

von Willebrand factor mediates protection of factor VIII from activated protein C-catalyzed inactivation

1991 • 125 citations

Epitope mapping of human factor VIII inhibitor antibodies by deletion analysis of factor VIII fragments expressed in Escherichia coli.

1988 • 122 citations

Localization of the binding regions of a murine monoclonal anti-factor VIII antibody and a human anti-factor VIII alloantibody, both of which inhibit factor VIII procoagulant activity, to amino acid residues threonine351-serine365 of the factor VIII heavy chain.

1988 • 77 citations

A monoclonal antibody (NMC‐VIII/10) to factor VIII light chain recognizing Glu¹⁶⁷⁵–Glu¹⁶⁸⁴ inhibits factor VIII binding to endogenous von Willebrand factor in human umbilical vein endothelial cells

1992 • 23 citations