Inhibitors in hemophilia patients: Current status and management

Twenty‐five years' experience of prophylactic treatment in severe haemophilia A and B

1992 • 958 citations

Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs

1992 • 613 citations

Recombinant Factor VIII for the Treatment of Previously Untreated Patients with Hemophilia A -- Safety, Efficacy, and Development of Inhibitors

1993 • 482 citations

Frapper fort ou doucement:A Gramnegative dilemma.

1978 • 358 citations

A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group.

1994 • 352 citations

A More Uniform Measurement of Factor VIII Inhibitors

1975 • 316 citations

The Effect of Activated Prothrombin-Complex Concentrate (FEIBA) on Joint and Muscle Bleeding in Patients with Hemophilia A and Antibodies to Factor VIII

1981 • 303 citations

Hematology: Basic Principles and Practice

1991 • 299 citations

Induction of Immune Tolerance in Patients with Hemophilia and Antibodies to Factor VIII by Combined Treatment with Intravenous IgG, Cyclophosphamide, and Factor VIII

1988 • 292 citations

Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells

1988 • 270 citations

Human Recombinant DNA–Derived Antihemophilic Factor (Factor VIII) in the Treatment of Hemophilia A

1990 • 261 citations

Efficacy of Prothrombin-Complex Concentrates in Hemophiliacs with Antibodies to Factor VIII

1980 • 257 citations

A Higher than Expected Incidence of Factor VIII Inhibitors in Multitransfused Haemophilia A Patients Treated with an Intermediate Purity Pasteurized Factor VIII Concentrate

1993 • 189 citations

Recombinant Factor VIII for the Treatment of Previously Untreated Patients with Hemophilia A

1993 • 183 citations

Molecular basis of factor VIII inhibition by human antibodies. Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid.

1989 • 183 citations

The use of factor eight inhibitor by-passing activity (FEIBA immuno) product for treatment of bleeding episodes in hemophiliacs with inhibitors

1983 • 182 citations

A sudden increase in factor VIII inhibitor development in multitransfused hemophilia A patients in The Netherlands. Dutch Hemophilia Study Group

1993 • 179 citations

A sudden increase in factor VIII inhibitor development in multitransfused hemophilia A patients in The Netherlands. Dutch Hemophilia Study Group

1993 • 172 citations

The natural history of factor VIII:C inhibitors in patients with hemophilia A: a national cooperative study. II. Observations on the initial development of factor VIII:C inhibitors

1988 • 171 citations

A Multicenter Study of Recombinant Factor VIII (Recombinate): Safety, Efficacy, and Inhibitor Risk in Previously Untreated Patients With Hemophilia A

1994 • 162 citations

The Use of Porcine Factor VIII Concentrate (Hyate:C) in the Treatment of Patients With Inhibitor Antibodies to Factor VIII

1989 • 151 citations

Localization of human factor FVIII inhibitor epitopes to two polypeptide fragments.

1985 • 144 citations

Efficacy and safety of vapor‐heated anti‐inhibitor coagulant complex in hemophilia patients. FEIBA Study Group

1990 • 131 citations

Localization of epitopes for human factor VIII inhibitor antibodies by immunoblotting and antibody neutralization

1989 • 130 citations

Induction of Immune Tolerance to Factor VIII in Hemophiliacs With Inhibitors

1988 • 126 citations

Clinical experience with polyelectrolyte-fractionated porcine factor VIII concentrate in the treatment of hemophiliacs with antibodies to factor VIII

1984 • 119 citations

Factor VIII inhibitors

1985 • 109 citations

Disappearance of factor VIII:C antibodies in patients with haemophilia A upon frequent administration of factor VIII in intermediate or low dose

1986 • 107 citations

Incidence of inhibitors in patients with severe and moderate hemophilia a treated with factor VIII concentrates

1987 • 77 citations

Treatment of Hemophilia A with a Highly Purified Factor VIII Concentrate Prepared by Anti-FVIIIc Immunoaffinity Chromatography

1992 • 72 citations

Antibodies to factor VIII. V. Patterns of immune response to factor VIII in hemophilia A

1976 • 71 citations

Induction of split tolerance and clinical cure in high-responding hemophiliacs with factor IX antibodies.

1986 • 68 citations

Haemophiliacs with factor VIII inhibitors in Finland: prevalence, incidence and outcome

1990 • 66 citations

Antibodies to factor VIII. V. Patterns of immune response to factor VIII in hemophilia A

1976 • 65 citations

Use of recombinant activated factor VII for treatment of a retropharyngeal hemorrhage in a hemophilic patient with a high titer inhibitor

1989 • 63 citations

Noncoagulation inhibitory factor VIII antibodies after induction of tolerance to factor VIII in hemophilia A patients

1990 • 60 citations

Viral safety and inhibitor development associated with factor VIIIC ultra-purified from plasma in hemophiliacs previously unexposed to factor VIIIC concentrates. The Monoclate Study Group.

1990 • 54 citations

A Soluble Recombinant Factor VIII Fragment Containing the A2 Domain Binds to Some Human Anti-Factor VIII Antibodies that Are not Detected by Immunoblotting

1992 • 51 citations

The pathways of blood coagulationl.

1967 • 48 citations

Incidence of inhibitor development in a group of young hemophilia A patients treated exclusively with lyophilized cryoprecipitate

1993 • 47 citations

Suppression of Secondary Antibody Response by Intravenous Immunoglobulin in a Patient with Haemophilia B and Antibodies

1983 • 47 citations

The Importance of Corticoids Added to Continued Treatment with Factor VIII Concentrates in the Suppression of Inhibitors in Haemophilia A

1984 • 42 citations

Treatment of factor VIII inhibitors.

1990 • 39 citations

Management of Hemophilia Patients with Inhibitors

1992 • 39 citations

Factor VIII Inhibitor bypassing activity: A suggested mechanism of action

1981 • 38 citations

Immunoadsorption for coagulation factor inhibitors

1991 • 33 citations

The interaction between factor VIII clotting antigen (VIIICAg) and phospholipid

1983 • 33 citations

In vitro evaluation of factor VIII--bypassing activity of activated prothrombin complex concentrate, prothrombin complex concentrate, and factor VIIa in the plasma of patients with factor VIII inhibitors: thrombin generation test in the presence of collagen-activated platelets.

1993 • 19 citations

Management of Haemophilia A with Antibodies - The Effect of Combined Treatment with Factor VIII, Hydrocortisone and Cyclophosphamide

1985 • 16 citations

FRESH-PLATELET TRANSFUSIONS IN HÆMOPHILIC PATIENTS WITH FACTOR-VIII ANTIBODY

1975 • 11 citations

Management of Factor VIII Inhibitors: Evolution and Current Status

1992 • 9 citations

Use of an animal model to evaluate hemophilia therapies.

1984 • 4 citations