Natural autoantibodies: from ‘horror autotoxicus’ to ‘gnothi seauton’

Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.

1990 • 672 citations

Fundamental Immunology

1990 • 607 citations

CD5+ B lymphocytes, polyreactive antibodies and the human B-cell repertoire

1989 • 461 citations

Natural Antibodies and the Immune Response

1966 • 312 citations

Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families.

1989 • 234 citations

Autoantibodies to cytokines - friends or foes?

1990 • 216 citations

Beyond Clonal Selection and Network

1989 • 215 citations

Murine Natural Monoclonal Autoantibodies: A Study of their Polyspecificities and their Affinities

1986 • 215 citations

Principles of Bacteriology and Immunity

1956 • 213 citations

Structure of Antibody-Antigen Complexes: Implications for Immune Recognition

1988 • 207 citations

Autoantibodies and the physiological role of immunoglobulins

1983 • 203 citations

A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus.

1986 • 197 citations

Autonomous activation of B and T cells in antigen-free mice

1986 • 184 citations

IgG autoantibody activity in normal mouse serum is controlled by IgM.

1990 • 154 citations

Natural autoantibodies might prevent autoimmune disease

1986 • 136 citations

A human monoclonal macroglobulin with specificity for alpha(2----8)-linked poly-N-acetyl neuraminic acid, the capsular polysaccharide of group B meningococci and Escherichia coli K1, which crossreacts with polynucleotides and with denatured DNA.

1986 • 125 citations

In vivo suppression of perinatal multispecific B cells results in a distortion of the adult B cell repertoire

1986 • 115 citations

The Significance of Natural Autoantibodies

1988 • 112 citations

Specificity of natural serum antibodies present in phylogenetically distinct fish species.

1988 • 107 citations

A study of anti-group A streptococcal monoclonal antibodies cross-reactive with myosin.

1986 • 105 citations

V Genes Encoding Autoantibodies: Molecular and Phenotypic Characteristics

1988 • 89 citations

Studies on natural antibodiesand autoantibodies

1983 • 85 citations

The genetic origin of autoantibodies

1987 • 83 citations

Hybrids from normal, germ free, nude and neonatal mice produce monoclonal autoantibodies to eight different intracellular structures.

1985 • 80 citations

Natural autoantibodies in systemic lupus erythematosus.

1987 • 72 citations

Comparison between autoantibodies arising during Trypanosoma cruzi infection in mice and natural autoantibodies.

1990 • 68 citations

Recognition of Self and Non-Self Constituents by Polyspecific Autoreceptors

1988 • 65 citations

Autoimmunity: the moving boundaries between physiology and pathology

1988 • 54 citations

Effect of immunoglobulin M from normal human serum on Leishmania donovani promastigote agglutination, complement-mediated killing, and phagocytosis by human monocytes

1989 • 50 citations

Presence of natural autoantibodies in hyperimmunized mice.

1985 • 48 citations

Natural anti-TNP antibodies from rainbow trout interfere with viral infection in vitro

1989 • 43 citations

Suppression of anti-DNA antibody production in MRL mice by treatment with anti-idiotypic antibodies.

1987 • 35 citations

Phagocytosis of Keratin Filament Aggregates Following Opsonization With IgG-Anti-Keratin Filament Autoantibodies

1987 • 33 citations

Suppression of antibody responses to the acetylcholine receptor by natural antibodies

1989 • 32 citations

Affinity chromatography of catalytic autoantibody to vasoactive intestinal peptide.

1990 • 26 citations

Low natural antibody and low in vivo tumor resistance, in xid-bearing B-cell deficient mice.

1989 • 25 citations

IgA Polyspecific autoantibodies in IgA nephropathy

1990 • 21 citations

Poly(Glu⁶⁰Ala³⁰Tyr¹⁰) (GAT)‐induced IgG monoclonal antibodies cross‐react with various self and non‐self antigens through the complementarity determining regions. Comparison with IgM monoclonal polyreactive natural antibodies

1990 • 18 citations

Anti-DNA antibodies and the problem of autoimmunity

1986 • 16 citations

Auto-antibodies specific for β2 microglobulin in normal human serum

1983 • 16 citations

Mouse natural autoantibodies can interfere with murine alpha and beta interferons

1989 • 10 citations

Inhibition of human natural killer cell activity by polyclonal IgM

1989 • 8 citations