Morphological effects of wortmannin on the endosomal system and GLUT4-containing compartments in rat adipose cells

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

1994 • 923 citations

Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.

1991 • 874 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

1994 • 620 citations

Phosphoinositide kinases

1996 • 529 citations

Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes.

1995 • 459 citations

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

1994 • 436 citations

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

1994 • 362 citations

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.

1995 • 349 citations

A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids.

1995 • 349 citations

Rab4 and cellubrevin define different early endosome populations on the pathway of transferrin receptor recycling.

1996 • 338 citations

The Effects of Wortmannin on Rat Skeletal Muscle

1995 • 320 citations

Disruption of PDGF Receptor Trafficking by Mutation of Its PI-3 Linase Binding Sites

1994 • 297 citations

Glycoproteins of the lysosomal membrane.

1985 • 294 citations

Insulin-Stimulated GLUT4 Translocation Is Relevant to the Phosphorylation of IRS-1 and the Activity of PI3 Kinase

1993 • 277 citations

Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.

1995 • 263 citations

A monoclonal antibody against a 135-K Golgi membrane protein.

1982 • 262 citations

Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

1995 • 255 citations

Potential Role of Protein Kinase B in Glucose Transporter 4 Translocation in Adipocytes*

1997 • 252 citations

Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast.

1995 • 248 citations

Activated Phosphatidylinositol 3-Kinase Is Sufficient to Mediate Actin Rearrangement and GLUT4 Translocation in 3T3-L1 Adipocytes

1996 • 239 citations

An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts.

1987 • 237 citations

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.

1994 • 234 citations

Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle.

1993 • 220 citations

Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes.

1995 • 202 citations

Overexpression of Catalytic Subunit p110α of Phosphatidylinositol 3-Kinase Increases Glucose Transport Activity with Translocation of Glucose Transporters in 3T3-L1 Adipocytes

1996 • 194 citations

Subcellular Locations of Phosphatidylinositol 4-Kinase Isoforms

1997 • 180 citations

Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin.

1996 • 180 citations

The effect of wortmannin on the localisation of lysosomal type I integral membrane glycoproteins suggests a role for phosphoinositide 3-kinase activity in regulating membrane traffic late in the endocytic pathway

1996 • 175 citations

Phosphatidylinositol 3-Kinase Activity Is Required at a Postendocytic Step in Platelet-derived Growth Factor Receptor Trafficking

1995 • 165 citations

Expression of VAMP-2-like protein in kidney collecting duct intracellular vesicles. Colocalization with Aquaporin-2 water channels.

1995 • 158 citations

Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro.

1996 • 156 citations

Roles of 1-Phosphatidylinositol 3-Kinase and ras in Regulating Translocation of GLUT4 in Transfected Rat Adipose Cells

1995 • 149 citations

Insulin-stimulated GLUT4 Translocation Is Mediated by a Divergent Intracellular Signaling Pathway

1995 • 146 citations

Targeting signals and subunit interactions in coated vesicle adaptor complexes.

1995 • 145 citations

Requirement for Phosphoinositide 3-Kinase in Insulin-Stimulated GLUT4 Translocation in 3T3-L1 Adipocytes

1995 • 143 citations

Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells: possible role in aquaporin-2 trafficking.

1996 • 137 citations

Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution.

1992 • 137 citations

Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes

1996 • 132 citations

Insulin-mediated Targeting of Phosphatidylinositol 3-Kinase to GLUT4-containing Vesicles

1996 • 129 citations

Wortmannin-sensitive Trafficking Pathways in Chinese Hamster Ovary Cells

1996 • 129 citations

Phosphoinositide 3-kinases and membrane traffic

1996 • 124 citations

Phosphatidylinositol 3-kinase activity is required for early endosome fusion

1995 • 119 citations

Cloning, Expression, and Localization of 230-kDa Phosphatidylinositol 4-Kinase

1996 • 114 citations

Immunocytochemical Evidence that GLUT4 Resides in a Specialized Translocation Post-endosomal VAMP2-positive Compartment in Rat Adipose Cells in the Absence of Insulin

1997 • 101 citations

Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells

1996 • 98 citations

Improvement in in vitro insulin action after one month of insulin therapy in obese noninsulin-dependent diabetics. Measurements of glucose transport and metabolism, insulin binding, and lipolysis in isolated adipocytes.

1983 • 96 citations

Phosphatidylinositol 3‐kinase regulation of fluid phase endocytosis

1995 • 79 citations

Receptor signalling and the regulation of endocytic membrane transport

1996 • 76 citations

Inhibitors of Phosphoinositide 3-Kinase Block Exocytosis but Not Endocytosis of Transferrin Receptors in 3T3-L1 Adipocytes

1995 • 72 citations

Okadaic acid treatment leads to a fragmentation of the trans-Golgi network and an increase in expression of TGN38 at the cell surface

1994 • 67 citations

GLUT4 in cultured skeletal myotubes is segregated from the transferrin receptor and stored in vesicles associated with the TGN

1996 • 54 citations

Vp165 and GLUT4 share similar vesicle pools along their trafficking pathways in rat adipose cells

1997 • 54 citations

Effects of Wortmannin on Increased Glucose Transport by Insulin and Norepinephrine in Primary Culture of Brown Adipocytes

1994 • 50 citations

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ADIPOSE CELL

1970 • 48 citations

The effects of wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, on insulin-stimulated glucose transport, GLUT4 translocation, antilipolysis, and DNA synthesis

1995 • 40 citations

Phosphatidylinositol 3′-kinase, But Not p70 Ribosomal S6 Kinase, Is Involved in Membrane Protein Recycling: Wortmannin Inhibits Glucose Transport and Downregulates Cell-Surface Transferrin Receptor Numbers Independently of Any Effect on Fluid-phase Endocytosis in Fibroblasts

1996 • 40 citations

Phosphatidylinositol 3-kinase is not required for recycling of mannose 6-phosphate receptors from late endosomes to the trans-Golgi network.

1997 • 29 citations

Hormonal regulation of glucose transport in a brown adipose cell preparation isolated from rats that shows a large response to insulin

1996 • 28 citations

Involvement of PI 3-kinase in stimulation of glucose transport and recruitment of transferrin receptors in 3T3-L1 adipocytes

1995 • 9 citations

Deleted Work

1955 • 0 citations