Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast.

Experiments in molecular genetics

1972 • 28,260 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Oncogenes and signal transduction

1991 • 2,816 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

STRUCTURE AND FUNCTION OF THE MANNOSE 6-PHOSPHATE/INSULINLIKE GROWTH FACTOR II RECEPTORS

1992 • 1,056 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

1988 • 977 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

The fungal vacuole: composition, function, and biogenesis

1990 • 758 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene

1994 • 500 citations

A rapid method for localized mutagenesis of yeast genes

1992 • 456 citations

Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae.

1990 • 443 citations

Activation of Phosphatidylinositol-3′ Kinase by Src-Family Kinase SH3 Binding to the p85 Subunit

1994 • 437 citations

Protein sorting in yeast: Mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway

1986 • 429 citations

Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit

1993 • 395 citations

Isolation of yeast mutants defective in protein targeting to the vacuole.

1986 • 394 citations

A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole.

1993 • 340 citations

Protein Sorting in Saccharomyces cerevisiae: Isolation of Mutants Defective in the Delivery and Processing of Multiple Vacuolar Hydrolases

1988 • 339 citations

Phosphoinositide kinases

1990 • 331 citations

Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase.

1989 • 330 citations

Protein sorting in yeast: The localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide

1987 • 329 citations

Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease

1987 • 312 citations

Disruption of PDGF Receptor Trafficking by Mutation of Its PI-3 Linase Binding Sites

1994 • 297 citations

Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae.

1989 • 258 citations

Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.

1994 • 245 citations

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

1989 • 228 citations

A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole

1991 • 204 citations

VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins.

1994 • 190 citations

Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton.

1993 • 162 citations

The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro.

1993 • 161 citations

Mutations in the VPS45 gene, a SEC1 homologue, result in vacuolar protein sorting defects and accumulation of membrane vesicles

1994 • 150 citations

Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation

1991 • 149 citations

Yeast carboxypeptidase Y vacuolar targeting signal is defined by four propeptide amino acids.

1990 • 147 citations

Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells

1994 • 131 citations

Characterization of VPS34, a Gene Required for Vacuolar Protein Sorting and Vacuole Segregation in Saccharomyces cerevisiae†

1990 • 126 citations

Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate.

1991 • 123 citations

Phosphatidylinositol 3-Kinase and Its Novel Product, Phosphatidylinositol 3-phosphate, Are Present in Saccharomyces cerevisiae

1989 • 118 citations

A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery.

1991 • 107 citations

Alternative pathways for the sorting of soluble vacuolar proteins in yeast: a vps35 null mutant missorts and secretes only a subset of vacuolar hydrolases.

1992 • 100 citations

The role of kinase activity and the kinase insert region in ligand-induced internalization and degradation of the c-fms protein.

1991 • 75 citations

Analysis of inositol metabolites produced by Saccharomyces cerevisiae in response to glucose stimulation.

1993 • 72 citations

Ligand and Protein Kinase C Downmodulate the Colony-Stimulating Factor 1 Receptor by Independent Mechanisms

1989 • 70 citations

Internalization of Activated Platelet-Derived Growth Factor Receptor-Phosphatidylinositol-3' Kinase Complexes: Potential Interactions with the Microtubule Cytoskeleton

1993 • 43 citations

Phosphatidylinositol-3 Kinase and Growth Regulation

1992 • 26 citations