PERMEATION AND SELECTIVITY OF TRP CHANNELS

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

1997 • 10,943 citations

The capsaicin receptor: a heat-activated ion channel in the pain pathway

1997 • 8,634 citations

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

1998 • 6,595 citations

SWISS-MODEL: an automated protein homology-modeling server

2003 • 5,370 citations

Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor

2000 • 3,436 citations

Ionic Channels of Excitable Membranes

1985 • 3,014 citations

TRP channels as cellular sensors

2003 • 2,625 citations

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

2002 • 2,513 citations

ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures

2003 • 2,386 citations

A TRP Channel that Senses Cold Stimuli and Menthol

2002 • 2,182 citations

Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution

2001 • 2,033 citations

Calcium signaling

1995 • 1,905 citations

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

1999 • 1,456 citations

Store depletion and calcium influx

1997 • 1,422 citations

Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor

2000 • 1,348 citations

Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.

1987 • 1,166 citations

[6] Correction for liquid junction potentials in patch clamp experiments

1992 • 1,148 citations

Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction

1989 • 1,119 citations

The trp ion channel family

2001 • 1,108 citations

Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells

1994 • 998 citations

The TRP Superfamily of Cation Channels

2005 • 980 citations

A Heat-Sensitive TRP Channel Expressed in Keratinocytes

2002 • 913 citations

LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability

2001 • 900 citations

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

2001 • 877 citations

Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers

2002 • 871 citations

Loss of Sex Discrimination and Male-Male Aggression in Mice Deficient for TRP2

2002 • 871 citations

TRPV3 is a calcium-permeable temperature-sensitive cation channel

2002 • 870 citations

Mechanism of ion permeation through calcium channels

1984 • 850 citations

Cation Selective Glass Electrodes and their Mode of Operation

1962 • 844 citations

Protein Modeling by E-mail

1995 • 839 citations

The TRP Channels, a Remarkably Functional Family

2002 • 822 citations

TRPV3 is a temperature-sensitive vanilloid receptor-like protein

2002 • 811 citations

LTRPC2 Ca2+-Permeable Channel Activated by Changes in Redox Status Confers Susceptibility to Cell Death

2002 • 794 citations

Calcium channel characteristics conferred on the sodium channel by single mutations

1992 • 776 citations

Abnormal osmotic regulation in trpv4 ^-/- mice

2003 • 760 citations

Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family

2002 • 758 citations

TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain

2001 • 737 citations

TRP-PLIK, a Bifunctional Protein with Kinase and Ion Channel Activities

2001 • 714 citations

TRPM4 Is a Ca2+-Activated Nonselective Cation Channel Mediating Cell Membrane Depolarization

2002 • 700 citations

Polycystin-2 is an intracellular calcium release channel

2002 • 673 citations

Non‐selective conductance in calcium channels of frog muscle: calcium selectivity in a single‐file pore.

1984 • 643 citations

JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurements

1994 • 628 citations

Functional interaction between InsP3 receptors and store-operated Htrp3 channels

1998 • 620 citations

Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

1993 • 614 citations

TRPM6 Forms the Mg2+ Influx Channel Involved in Intestinal and Renal Mg2+ Absorption

2003 • 610 citations

Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells.

1986 • 594 citations

Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4−/− mice

2001 • 567 citations

Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia

2002 • 543 citations

CALCIUM CHANNELS: Mechanisms of Selectivity, Permeation, and Block

1987 • 528 citations

A transient receptor potential channel expressed in taste receptor cells

2002 • 501 citations

From worm to man: three subfamilies of TRP channels

2000 • 490 citations

TRPM7 Provides an Ion Channel Mechanism for Cellular Entry of Trace Metal Ions

2002 • 489 citations

The diversity in the vanilloid (TRPV) receptor family of ion channels

2002 • 485 citations

Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I

1999 • 473 citations

TRPV4 calcium entry channel: a paradigm for gating diversity

2004 • 469 citations

Molecular and Functional Characterization of a Novel Mouse Transient Receptor Potential Protein Homologue TRP7

1999 • 451 citations

Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca ²⁺ -permeable nonselective cation channel

2000 • 446 citations

Immunocyte Ca ²⁺ Influx System Mediated by LTRPC2

2001 • 434 citations

Receptor-mediated Regulation of the Nonselective Cation Channels TRPC4 and TRPC5

2000 • 422 citations

Ion‐concentration dependence of the reversal potential and the single channel conductance of ion channels at the frog neuromuscular junction.

1979 • 394 citations

Cloning and Functional Expression of a Human Ca2+-Permeable Cation Channel Activated by Calcium Store Depletion

1996 • 391 citations

TRPM5 Is a Voltage-Modulated and Ca2+-Activated Monovalent Selective Cation Channel

2003 • 386 citations

The cellular and molecular basis of store-operated calcium entry

2002 • 366 citations

Impairment of Store-Operated Ca ²⁺ Entry in TRPC4 ^−/− Mice Interferes With Increase in Lung Microvascular Permeability

2002 • 363 citations

Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1

2003 • 354 citations

CaT1 manifests the pore properties of the calcium-release-activated calcium channel

2001 • 350 citations

Voltage Dependence of the Ca2+-activated Cation Channel TRPM4

2003 • 348 citations

Molecular and Functional Characterization of the Melastatin-related Cation Channel TRPM3

2003 • 345 citations

TRPM5 is a transient Ca ²⁺ -activated cation channel responding to rapid changes in [Ca ²⁺ ] _i

2003 • 343 citations

The mammalian TRPC cation channels

2004 • 332 citations

Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6

2003 • 332 citations

Permeation and Gating Properties of the Novel Epithelial Ca2+ Channel

2000 • 318 citations

Molecular Determinants of Permeation through the Cation Channel TRPV4

2002 • 313 citations

A Diacylglycerol-Gated Cation Channel in Vomeronasal Neuron Dendrites Is Impaired in TRPC2 Mutant Mice

2003 • 313 citations

A novel capacitative calcium entry channel expressed in excitable cells

1998 • 308 citations

Molecular Cloning and Functional Characterization of a Novel Receptor-activated TRP Ca2+ Channel from Mouse Brain

1998 • 294 citations

A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL.

1996 • 286 citations

Lanthanides Potentiate TRPC5 Currents by an Action at Extracellular Sites Close to the Pore Mouth

2003 • 260 citations

Permeation and Selectivity in Calcium Channels

2003 • 256 citations

International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential Channels

2003 • 251 citations

CaT1 and the Calcium Release-activated Calcium Channel Manifest Distinct Pore Properties

2001 • 236 citations

Function and expression of the epithelial Ca2+ channel family: comparison of mammalian ECaC1 and 2

2001 • 234 citations

Polycystin-L is a calcium-regulated cation channel permeable to calcium ions

1999 • 223 citations

Ca2+-dependent Potentiation of the Nonselective Cation Channel TRPV4 Is Mediated by a C-terminal Calmodulin Binding Site

2003 • 223 citations

The Ca channel in skeletal muscle is a large pore.

1985 • 219 citations

Alternative Splicing Switches the Divalent Cation Selectivity of TRPM3 Channels

2005 • 216 citations

Molecular Mechanism of Active Ca²⁺ Reabsorption in the Distal Nephron

2002 • 215 citations

Expression and Characterization of Human Transient Receptor Potential Melastatin 3 (hTRPM3)

2003 • 211 citations

Function and expression of the epithelial Ca2+ channel family: comparison of mammalian ECaC1 and 2

2001 • 194 citations

The epithelial calcium channels, TRPV5 & TRPV6: from identification towards regulation

2003 • 191 citations

Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells

2004 • 190 citations

TRPC1 Is Required for Functional Store-operated Ca2+ Channels

2003 • 181 citations

Identification of an Aspartic Residue in the P-loop of the Vanilloid Receptor That Modulates Pore Properties

2000 • 180 citations

Native Polycystin 2 Functions as a Plasma Membrane Ca²⁺-Permeable Cation Channel in Renal Epithelia

2003 • 180 citations

Properties of heterologously expressed hTRP3 channels in bovine pulmonary artery endothelial cells

1999 • 177 citations

Identification and characterization of the single channel function of human mucolipin‐1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway

2002 • 173 citations

TRPM2 Ca2+ permeable cation channels: from gene to biological function

2003 • 173 citations

The Single Pore Residue Asp542 Determines Ca2+ Permeation and Mg2+ Block of the Epithelial Ca2+ Channel

2001 • 172 citations

TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels

2003 • 172 citations

Trp proteins form store‐operated cation channels in human vascular endothelial cells

1998 • 162 citations

Current understanding of mammalian TRP homologues

2002 • 158 citations

Mg2+-dependent Gating and Strong Inward Rectification of the Cation Channel TRPV6

2003 • 155 citations

Whole‐cell and single channel monovalent cation currents through the novel rabbit epithelial Ca²⁺ channel ECaC

2000 • 155 citations

Cell Swelling and a Nonselective Cation Channel Regulated by Internal Ca²⁺and ATP in Native Reactive Astrocytes from Adult Rat Brain

2001 • 152 citations

TRPV1 Acts as Proton Channel to Induce Acidification in Nociceptive Neurons

2004 • 150 citations

Vanilloid and TRP channels: a family of lipid-gated cation channels

2002 • 149 citations

The Selectivity Filter of the Cation Channel TRPM4

2005 • 145 citations

Outer Pore Architecture of a Ca2+-selective TRP Channel

2004 • 131 citations

Functional Analysis of Capsaicin Receptor (Vanilloid Receptor Subtype 1) Multimerization and Agonist Responsiveness Using a Dominant Negative Mutation

2001 • 124 citations

Mechanism and Molecular Determinant for Regulation of Rabbit Transient Receptor Potential Type 5 (TRPV5) Channel by Extracellular pH

2003 • 111 citations

Ion Channel Selectivity through Stepwise Changes in Binding Affinity

1998 • 104 citations

Epithelial calcium channels: from identification to function and regulation

2003 • 99 citations

Phenotype of a recombinant store‐operated channel: highly selective permeation of Ca²⁺

1999 • 95 citations

Invertebrate TRP proteins as functional models for mammalian channels

2004 • 92 citations

Identification of four trp 1 gene variants murine pancreatic beta-cells

1997 • 91 citations

Pore properties and ionic block of the rabbit epithelial calcium channel expressed in HEK 293 cells

2001 • 79 citations

A Cytosolic Residue Mediates Mg²⁺Block and Regulates Inward Current Amplitude of a Transient Receptor Potential Channel

2005 • 74 citations

Regulation by voltage and adenine nucleotides of a Ca2+-activated cation channel from hamster vomeronasal sensory neurons

2003 • 74 citations

(Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6

2003 • 73 citations

ECaC: the gatekeeper of transepithelial Ca2+ transport

2002 • 67 citations

A polycystin-2-like large conductance cation channel in rat left ventricular myocytes

2003 • 66 citations

Regulation by voltage and adenine nucleotides of a Ca2+-activated cation channel from hamster vomeronasal sensory neurons

2003 • 66 citations

Aspartate Residues of the Glu-Glu-Asp-Asp (EEDD) Pore Locus Control Selectivity and Permeation of the T-type Ca2+Channel α1G

2001 • 65 citations

Modeling of the Outer Vestibule and Selectivity Filter of the L-Type Ca²⁺ Channel

2001 • 62 citations

Modulation of the epithelial Ca 2+ channel ECaC by extracellular pH

2001 • 60 citations

Outer Pore Topology of the ECaC-TRPV5 Channel by Cysteine Scan Mutagenesis

2004 • 54 citations

Differences in Apparent Pore Sizes of Low and High Voltage-activated Ca2+ Channels

2002 • 51 citations

Molecular Elements of Ion Permeation and Selectivity within Calcium Channels

1999 • 50 citations

From the Cover: Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel

2000 • 49 citations

The pore of TRP channels: trivial or neglected?

2003 • 44 citations

Nonselective Cation Channels in Endothelial Cells Derived from Human Umbilical Vein

1999 • 43 citations

Spontaneous single-channel activity of neuronal TRP5 channel recombinantly expressed in HEK293 cells

2000 • 41 citations

Chemical Dynamics: Papers in Honor of Henry Eyring

1971 • 38 citations

Biogenesis and Topology of the Transient Receptor Potential Ca2+ Channel TRPC1

2004 • 31 citations

Untitled

1999 • 17 citations