Control of signal transduction and morphogenesis by Ras

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

The pathway to signal achievement

1993 • 563 citations

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

1994 • 499 citations

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.

1992 • 427 citations

Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.

1991 • 369 citations

Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development.

1991 • 352 citations

Cooperative interaction of S. pombe proteins required for mating and morphogenesis

1994 • 303 citations

Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3.

1994 • 283 citations

Localization of F-actin through the cell division cycle of Schizosaccharomyces pombe

1985 • 280 citations

Role of a ras homolog in the life cycle of schizosaccharomyces pombe

1986 • 274 citations

Development of cell polarity in budding yeast

1991 • 252 citations

A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains

1992 • 219 citations

Cdc42p GTPase is involved in controlling polarized cell growth in Schizosaccharomyces pombe.

1994 • 217 citations

byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype.

1991 • 208 citations

A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae.

1993 • 189 citations

Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms.

1993 • 166 citations

THE PHEROMONE RESPONSE PATHWAY IN SACCHAROMYCES CEREVISIAE

1993 • 166 citations

A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast.

1988 • 153 citations

Homologous activators of ras in fission and budding yeast

1990 • 142 citations

Involvement of ras in sexual differentiation but not in growth control in fission yeast

1986 • 139 citations

Molecular cloning and sequence analysis of a ras gene from Schizosaccharomyces pombe.

1985 • 138 citations

The Schizosaccharomyces pombe mam2 gene encodes a putative pheromone receptor which has a significant homology with the Saccharomyces cerevisiae Ste2 protein.

1991 • 138 citations

The fission yeast mating pheromone P-factor: its molecular structure, gene structure, and ability to induce gene expression and G1 arrest in the mating partner.

1994 • 133 citations

Schizosaccharomyces pombe map3+ encodes the putative M-factor receptor.

1993 • 111 citations

Isolation and characterization of Schizosaccharomyces pombe mutants phenotypically similar to ras1 −

1988 • 100 citations

The ras1 function of Schizosaccharomyces pombe mediates pheromone-induced transcription.

1992 • 92 citations

Mating pheromone-like diffusible factor released by Schizosaccharomyces pombe

1986 • 92 citations

sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.

1991 • 77 citations

Identification of a GTPase-activating protein homolog in Schizosaccharomyces pombe.

1991 • 77 citations

Sex appeal in fission yeast

1987 • 75 citations

Mating pheromone‐induced expression of the MAT1‐Pm gene of Schizosaccharomyces pombe: Identification of signalling components and characterization of upstream controlling elements

1994 • 62 citations

Schizosaccharomyces pombe Spk1 is a Tyrosine-Phosphorylated Protein Functionally Related to Xenopus Mitogen-Activated Protein Kinase

1993 • 57 citations

The cloning and characterization of a RAS gene fromSchizosaccharomyces pombe

1986 • 52 citations

Mutations in cyr1 and pat1 reveal pheromone-induced G1 arrest in the fission yeast Schizosaccharomyces pombe

1994 • 52 citations

Characterization of the Schizosaccharomyces pombe ral2 gene implicated in activation of the ras1 gene product.

1989 • 46 citations

Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase.

1993 • 44 citations

Pheromone-induced meiosis in P-specific mutants of fission yeast

1989 • 38 citations

Transcriptional regulation of a ras nucleotide-exchange factor gene by extracellular signals in fission yeast

1994 • 37 citations

Functional conservation between Schizosaccharomyces pombe ste8 and Saccharomyces cerevisiae STE11 protein kinases in yeast signal transduction

1992 • 34 citations

Signal transduction in the budding yeast Saccharomyces cerevisiae

1994 • 29 citations

A homologue of the ras-related CDC42 gene from Schizosaccharomyces pombe

1992 • 25 citations