Pain, affective symptoms, and cognitive deficits in patients with cerebral dopamine dysfunction
Data up to Jan 2025
Total Citations Per Year
Abstract
References (174)
Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
2005 • 18,882 citations
Predictive Reward Signal of Dopamine Neurons
1998 • 4,446 citations
Depression and Pain Comorbidity
2003 • 3,096 citations
Human brain mechanisms of pain perception and regulation in health and disease
2005 • 2,917 citations
Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations
1973 • 2,615 citations
Non-motor symptoms of Parkinson's disease: diagnosis and management
2006 • 2,462 citations
The Mesolimbic Dopamine Reward Circuit in Depression
2006 • 1,931 citations
Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia
1991 • 1,819 citations
Pain-related fear is more disabling than pain itself: evidence on the role of pain-related fear in chronic back pain disability
1999 • 1,628 citations
Neurocircuitry of Mood Disorders
2009 • 1,508 citations
How does stress increase risk of drug abuse and relapse?
2001 • 1,450 citations
Multiple Dopamine Functions at Different Time Courses
2007 • 1,333 citations
Enzymatic O-Methylation of Epinephrine and Other Catechols
1958 • 1,291 citations
Genetic basis for individual variations in pain perception and the development of a chronic pain condition
2004 • 1,252 citations
Intermediate phenotypes and genetic mechanisms of psychiatric disorders
2006 • 1,210 citations
Pain catastrophizing: a critical review
2009 • 1,179 citations
The Role of Dopamine in the Pathophysiology of Depression
2007 • 1,159 citations
Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme
1995 • 1,152 citations
Differential Effect of Stress on In Vivo Dopamine Release in Striatum, Nucleus Accumbens, and Medial Frontal Cortex
1989 • 1,107 citations
Mesocorticolimbic dopaminergic network: functional and regulatory roles
1991 • 1,104 citations
COMT val 158 met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor
2003 • 1,103 citations
Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
2003 • 1,079 citations
Dopamine and the regulation of cognition and attention
2002 • 1,069 citations
Dopamine in drug abuse and addiction: results from imaging studies and treatment implications
2004 • 1,059 citations
Chronic Pain-Associated Depression: Antecedent or Consequence of Chronic Pain? A Review
1997 • 1,052 citations
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
1992 • 1,001 citations
Classical fear conditioning in the anxiety disorders: a meta-analysis
2005 • 1,000 citations
Increased baseline occupancy of D 2 receptors by dopamine in schizophrenia
2000 • 996 citations
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
2000 • 962 citations
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
1988 • 913 citations
Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers
1993 • 906 citations
Mood and anxiety disorders associated with chronic pain: an examination in a nationally representative sample
2003 • 904 citations
Fear and anxiety: divergent effects on human pain thresholds
2000 • 871 citations
Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens.
1995 • 857 citations
State-dependent opioid control of pain
2004 • 852 citations
Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain
2001 • 832 citations
The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes
2004 • 779 citations
Drug craving and addiction: integrating psychological and neuropsychopharmacological approaches
2003 • 747 citations
Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers
1999 • 728 citations
A common neurobiology for pain and pleasure
2008 • 724 citations
The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers
1998 • 679 citations
Catechol-o-Methyltransferase, Cognition, and Psychosis: Val158Met and Beyond
2006 • 667 citations
Allelic Association of the D2 Dopamine Receptor Gene With Receptor-Binding Characteristics in Alcoholism or Gene ism
1991 • 656 citations
Placebo and Nocebo Effects Are Defined by Opposite Opioid and Dopaminergic Responses
2008 • 611 citations
The role of the basal ganglia in nociception and pain
1995 • 600 citations
Dopaminergic innervation of the cerebral cortex: unexpected differences between rodents and primates
1991 • 584 citations
Dopamine Axon Varicosities in the Prelimbic Division of the Rat Prefrontal Cortex Exhibit Sparse Immunoreactivity for the Dopamine Transporter
1998 • 578 citations
Genotype Influences In Vivo Dopamine Transporter Availability in Human Striatum
2000 • 550 citations
Prevalence and Characteristics of Chronic Pain Among Chemically Dependent Patients in Methadone Maintenance and Residential Treatment Facilities
2003 • 519 citations
Prospective study on the relationship between depressive symptoms and chronic musculoskeletal pain
1994 • 514 citations
Predicting Value of Pain and Analgesia: Nucleus Accumbens Response to Noxious Stimuli Changes in the Presence of Chronic Pain
2010 • 508 citations
Chronic pain patients are impaired on an emotional decision-making task
2004 • 504 citations
Direct and indirect pathways from the amygdala to the frontal lobe in rhesus monkeys
1981 • 494 citations
Profound Decreases in Dopamine Release in Striatum in Detoxified Alcoholics: Possible Orbitofrontal Involvement
2007 • 461 citations
Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis
2009 • 457 citations
Pain in Parkinson’s disease: Prevalence and characteristics
2008 • 449 citations
Individual Differences in Reward Responding Explain Placebo-Induced Expectations and Effects
2007 • 447 citations
Distribution of D1- and D2-Dopamine Receptors, and Dopamine and Its Metabolites in the Human Brain
1994 • 408 citations
A cross-national study of the course of persistent pain in primary care
2001 • 407 citations
Efferents and afferents of the ventral tegmental-A10 region studied after local injection of [3H]leucine and horseradish peroxidase
1979 • 405 citations
Fibromyalgia patients show an abnormal dopamine response to pain
2007 • 391 citations
Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress
1995 • 390 citations
Imaging endogenous dopamine competition with [11C]raclopride in the human brain
1994 • 378 citations
Effects of attention on the intensity and unpleasantness of thermal pain
1989 • 366 citations
Effects of Major Depression on Remission and Relapse of Substance Dependence
2002 • 360 citations
Striatal Dopamine D2/D3Receptor Availability Is Reduced in Methamphetamine Dependence and Is Linked to Impulsivity
2009 • 358 citations
Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.
1997 • 358 citations
Motivation, reward, and Parkinson's disease: influence of dopatherapy
2002 • 341 citations
The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies
2000 • 332 citations
Low Dopamine D2 Receptor Binding Potential in Social Phobia
2000 • 325 citations
Parkinson's disease and anxiety: Comorbidity with depression
1993 • 313 citations
The Primate Thalamus Is a Key Target for Brain Dopamine
2005 • 311 citations
Anxiety and depression associated with migraine: Influence on migraine subjects' disability and quality of life, and acute migraine management
2005 • 308 citations
Dopamine receptor subtypes: beyond the D1/D2 classification
1990 • 295 citations
Variations in the Human Pain Stress Experience Mediated by Ventral and Dorsal Basal Ganglia Dopamine Activity
2006 • 288 citations
Association of seven polymorphisms of the D2 dopamine receptor gene with brain receptor-binding characteristics.
2003 • 288 citations
Chronic pain and neuropsychological functioning.
2000 • 284 citations
Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs
1997 • 284 citations
Pain Insensitivity in Schizophrenia: A Neglected Phenomenon and Some Implications
1994 • 276 citations
Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome
2003 • 276 citations
Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism
2003 • 271 citations
Psychological resilience predicts decreases in pain catastrophizing through positive emotions.
2010 • 269 citations
Disruption of Attention and Working Memory Traces in Individuals with Chronic Pain
2007 • 268 citations
Catechol- O -methyltransferase inhibition increases pain sensitivity through activation of both β2- and β3-adrenergic receptors
2006 • 268 citations
Regional changes in dopamine and serotonin activation with various intensity of physical and psychological stress in the rat brain
1994 • 261 citations
Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene.
2005 • 260 citations
Role of the dopaminergic system in chronic pain – a fluorodopa-PET study
2001 • 251 citations
Striatal dopamine D1 and D2 receptors in burning mouth syndrome
2002 • 250 citations
Dopamine reuptake site densities in patients with social phobia
1997 • 249 citations
Reduced Presynaptic Dopamine Activity in Fibromyalgia Syndrome Demonstrated With Positron Emission Tomography: A Pilot Study
2006 • 240 citations
Genetic Gating of Human Fear Learning and Extinction
2009 • 238 citations
Pain as a Nonmotor Symptom of Parkinson Disease
2008 • 227 citations
Clinical Aspects of Depression in Chronic Pain Patients
1991 • 220 citations
Morphine-dopamine interaction: Ventral tegmental morphine increases nucleus accumbens dopamine release
1991 • 218 citations
Neurophysiologic study of central pain in patients with Parkinson disease
2007 • 218 citations
The involvement of dopamine in nociception: the role of D1 and D2 receptors in the dorsolateral striatum
2000 • 216 citations
Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 dopamine receptor antagonist activity and limbic selectivity.
1997 • 215 citations
Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study
2007 • 213 citations
Dopamine and migraine
1997 • 206 citations
A Psychophysical Evaluation of the Relationship Between Trait Anxiety, Pain Perception, and Induced State Anxiety
2005 • 206 citations
PAINFUL PARKINSON'S DISEASE
1986 • 205 citations
Depression and changed pain perception: Hints for a central disinhibition mechanism
2008 • 199 citations
Altered dopamine D2 receptor binding in atypical facial pain
2003 • 199 citations
Treatment needs associated with pain in substance use disorder patients: implications for concurrent treatment
2003 • 188 citations
Persistent pain is associated with substance use after detoxification: a prospective cohort analysis
2007 • 188 citations
A Survey of Pain in Idiopathic Parkinson's Disease
2006 • 185 citations
High-activity catechol-O-methyltransferase allele is more prevalent in polysubstance abusers
1997 • 181 citations
Ventral Striatal Dopamine Release in Response to Smoking a Regular vs a Denicotinized Cigarette
2008 • 180 citations
Differential reactivity of dopaminergic neurons in the nucleus accumbens in response to different behavioral situations. An in vivo voltammetric study in free moving rats
1986 • 169 citations
Gene–gene effects on central processing of aversive stimuli
2007 • 167 citations
Attentional control in Parkinson's disease is dependent on COMT val158met genotype
2008 • 167 citations
D2 dopamine receptor polymorphism and brain regional glucose metabolism
1997 • 164 citations
Effects of mood on pain responses and pain tolerance: An experimental study in chronic back pain patients
2008 • 163 citations
Neural substrates of reward magnitude, probability, and risk during a wheel of fortune decision-making task
2008 • 162 citations
The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate
2004 • 161 citations
D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene
1998 • 156 citations
Striatal Dopamine Transporter Availability Associated with Polymorphisms in the Dopamine Transporter Gene SLC6A3
2008 • 154 citations
Stimulation of dopamine D2 receptors in the nucleus accumbens inhibits inflammatory pain
2003 • 152 citations
Dopamine Reuptake Inhibition in the Rostral Agranular Insular Cortex Produces Antinociception
1999 • 149 citations
Understanding How Opioids Contribute to Reward and Analgesia
2007 • 148 citations
Quality of life and pain in Parkinson's disease: a controlled cross-sectional study
2004 • 144 citations
Dopamine D2 receptor binding in the human brain is associated with the response to painful stimulation and pain modulatory capacity
2002 • 143 citations
The role of motivation in distracting attention away from pain: An experimental study
2010 • 137 citations
Comparative Efficacy of SSRIs and Amisulpride in Burning Mouth Syndrome
2002 • 130 citations
Reward‐aversion circuitry in analgesia and pain: Implications for psychiatric disorders
2006 • 124 citations
The association between panic disorder and the L/L genotype of catechol-O-methyltransferase
2004 • 121 citations
Planning ability in Parkinson's disease is influenced by the COMT val158met polymorphism
2004 • 119 citations
Use of levodopa to relieve pain from painful symmetrical diabetic polyneuropathy
1998 • 115 citations
Antipsychotics for acute and chronic pain in adults
2013 • 111 citations
Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22
2002 • 111 citations
Physical Pain and Associated Clinical Characteristics in Treatment‐Seeking Patients in Four Substance Use Disorder Treatment Modalities
2008 • 111 citations
The association of persistent pain with out‐patient addiction treatment outcomes and service utilization
2008 • 110 citations
Dopamine Type-1 Receptor Binding in Major Depressive Disorder Assessed Using Positron Emission Tomography and [11C]NNC-112
2008 • 109 citations
Hypoalgesia in schizophrenia is independent of antipsychotic drugs: A systematic quantitative review of experimental studies
2007 • 105 citations
Corticolimbic dysregulation and chronic methamphetamine abuse
2007 • 99 citations
Administration of Levodopa for Relief of Herpes Zoster Pain
1981 • 99 citations
Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian population-based longitudinal study of adolescent health
2005 • 98 citations
Activation of striatal dopamine receptors induces pain inhibition in rats
1981 • 95 citations
Pain insensitivity in the relatives of schizophrenia patients
2001 • 95 citations
Pain insensitivity in schizophrenia
1990 • 92 citations
Dopamine and NMDA systems modulate long-term nociception in the rat anterior cingulate cortex
2004 • 90 citations
PAIN PERCEPTION IN PATIENTS WITH SCHIZOPHRENIA
2002 • 89 citations
Dopamine receptors in the anterior insular cortex modulate long‐term nociception in the rat
2007 • 89 citations
Pain and Its Relationship to Depression in Parkinson Disease
2009 • 87 citations
Long-Term Memory for Pavlovian Fear Conditioning Requires Dopamine in the Nucleus Accumbens and Basolateral Amygdala
2010 • 87 citations
A genetic association study of dopamine metabolism‐related genes and chronic headache with drug abuse
2006 • 87 citations
Confirmation of an excess of the high enzyme activity COMTval allele in heroin addicts in a family-based haplotype relative risk study
2000 • 84 citations
Influence of antipsychotic medication on pain perception in schizophrenia
2006 • 81 citations
Striatal dopamine D2/D3 receptor availability correlates with individual response characteristics to pain
2004 • 78 citations
Occurrence of Painless Acute Surgical Disorders in Psychotic Patients
1959 • 74 citations
Cerebral morphology and dopamine D2/D3 receptor distribution in humans: A combined [18F]fallypride and voxel-based morphometry study
2009 • 71 citations
Associations between polymorphisms in dopamine neurotransmitter pathway genes and pain response in healthy humans
2009 • 69 citations
Association of striatal dopamine D2/D3 receptor binding potential with pain but not tactile sensitivity or placebo analgesia
2004 • 60 citations
Effect of amphetamine on extrastriatal D2 dopamine receptor binding in the primate brain: A PET study
2000 • 59 citations
Time‐course of change in [11C]carfentanil and [11C]raclopride binding potential after a nonpharmacological challenge
2007 • 56 citations
LEADING CAUSES OF DEATH IN INSTITUTIONALIZED CHRONIC SCHIZOPHRENIC PATIENTS: A STUDY OF 1,275 AUTOPSY PROTOCOLS
1966 • 55 citations
Catechol-O-methyltransferase polymorphism alters hypothalamic-pituitary-adrenal axis responses to naloxone: a preliminary report
2003 • 52 citations
The interrelationship of dopamine D2-like receptor availability in striatal and extrastriatal brain regions in healthy humans: A principal component analysis of [18F]fallypride binding
2010 • 51 citations
Levodopa Relief of Bone Pain from Breast Cancer
1972 • 47 citations
Striatal Extracellular Dopamine Levels in Rats with Haloperidol-Induced Depolarization Block of Substantia Nigra Dopamine Neurons
1998 • 46 citations
Positron emission tomography imaging of dopamine D2/3 receptors in the human cortex with [11C]FLB 457: Reproducibility studies
2010 • 46 citations
D2-like but not D1-like dopamine receptors are involved in the ventrolateral orbital cortex-induced antinociception: A GABAergic modulation mechanism
2008 • 45 citations
Effects of intravenous placebo with glucose expectation on human basal ganglia dopaminergic function
2008 • 39 citations
The role of dopamine receptors in ventrolateral orbital cortex-evoked anti-nociception in a rat model of neuropathic pain
2010 • 36 citations
Dopaminergic regulation of serotonin release in the substantia nigra of the freely moving rat using microdialysis
1998 • 36 citations
Evaluation of dopamine D2/3specific binding in the cerebellum for the positron emission tomography radiotracer [11C]FLB 457: Implications for measuring cortical dopamine release
2011 • 36 citations
Antipsychotics for Acute and Chronic Pain in Adults
2010 • 33 citations
Pain perception in patients with bipolar disorder and schizophrenia
2007 • 33 citations
Atypical antipsychotics in the treatment of fibromyalgia: a case series with olanzapine
2004 • 31 citations
The DRD2 TaqIA polymorphism associated with changed midbrain volumes in healthy individuals
2009 • 30 citations
Management of Pain in Addicted/Illicit and Legal Substance Abusing Patients
2005 • 23 citations
Dopaminergic hypersensitivity in migraine: clinical and genetic evidence.
2000 • 17 citations
Subcutaneous formalin enhances outflow of met-enkephalin- and cholecystokinin-like materials in the rat nucleus accumbens
2001 • 14 citations
Psychotropic medications in palliative care
2009 • 8 citations